Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury
Mark R. Looney, … , Clifford A. Lowell, Michael A. Matthay
Mark R. Looney, … , Clifford A. Lowell, Michael A. Matthay
Published October 5, 2009
Citation Information: J Clin Invest. 2009;119(11):3450-3461. https://doi.org/10.1172/JCI38432.
View: Text | PDF
Research Article Pulmonology

Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury

  • Text
  • PDF
Abstract

Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-associated mortality in the US. Previously, we established an immune-mediated TRALI mouse model, wherein mice with cognate antigen were challenged with MHC class I mAb. In this study, when mice housed in a rodent, specific pathogen–free barrier room were challenged with MHC I mAb, there was significant protection from TRALI compared with nonbarrier mice. Priming mice with LPS restored lung injury with mAb challenge. Using TLR4-deficient bone marrow chimeras, the priming phenotype was restricted to animals with WT hematopoietic cells, and depletion of either neutrophils or platelets was protective. Both neutrophils and platelets were sequestered in the lungs of mice with TRALI, and retention of platelets was neutrophil dependent. Interestingly, treatment with aspirin prevented lung injury and mortality, but blocking the P selectin or CD11b/CD18 pathways did not. These data suggest a 2-step mechanism of TRALI: priming of hematopoietic cells, followed by vascular deposition of activated neutrophils and platelets that then mediate the severe lung injury. Furthermore, our data offer an explanation for the increased incidence of TRALI in patients with immune priming conditions, and we suggest what we believe to be a novel therapeutic approach.

Authors

Mark R. Looney, John X. Nguyen, Yongmei Hu, Jessica A. Van Ziffle, Clifford A. Lowell, Michael A. Matthay

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Total
Citations: 1 7 5 18 11 24 12 12 12 17 23 18 13 17 16 8 1 215
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2020 (24)

Title and authors Publication Year
Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation
Guadalupe Ortiz-Munoz, Michelle A. Yu, Emma Lefrançais, Benat Mallavia, Colin Valet, Jennifer J. Tian, Serena Ranucci, Kristin M. Wang, Zhe Liu, Nicholas Kwaan, Diana Dawson, Mary Ellen Kleinhenz, Fadi T. Khasawneh, Peter M. Haggie, Alan S. Verkman, Mark R. Looney
Journal of Clinical Investigation 2020
Complement activation on endothelium initiates antibody-mediated acute lung injury
Simon J. Cleary, Nicholas Kwaan, Jennifer J. Tian, Daniel R. Calabrese, Beñat Mallavia, Mélia Magnen, John R. Greenland, Anatoly Urisman, Jonathan P. Singer, Steven R. Hays, Jasleen Kukreja, Ariel M. Hay, Heather L. Howie, Pearl Toy, Clifford A. Lowell, Craig N. Morrell, James C. Zimring, Mark R. Looney
Journal of Clinical Investigation 2020
Biological and structural characterization of murine TRALI antibody reveals increased Fc-mediated complement activation
EA van der Laan, S van der Velden, AE Bentlage, MD Larsen, TL van Osch, JY Mok, G Brasser, DM Geerdes, CA Koeleman, J Nouta, JW Semple, L Porcelijn, WJ van Esch, M Wuhrer, CE van der Schoot, G Vidarsson, R Kapur
Blood Advances 2020
Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation
JM Adrover, A Aroca-Crevillén, G Crainiciuc, F Ostos, Y Rojas-Vega, A Rubio-Ponce, C Cilloniz, E Bonzón-Kulichenko, E Calvo, D Rico, MA Moro, C Weber, I Lizasoaín, A Torres, J Ruiz-Cabello, J Vázquez, A Hidalgo
Nature Immunology 2020
Association Between Prior Aspirin Use and Acute Respiratory Distress Syndrome Incidence in At-Risk Patients: A Systematic Review and Meta-Analysis
H Liang, X Ding, H Li, L Li, T Sun
Frontiers in pharmacology 2020
Haem oxygenase protects against thrombocytopaenia and malaria-associated lung injury
IG de Azevedo-Quintanilha, IM Medeiros-de-Moraes, AC Ferreira, PA Reis, A Vieira-de-Abreu, RA Campbell, AS Weyrich, PT Bozza, GA Zimmerman, HC Castro-Faria-Neto
Malaria Journal 2020
Antiplatelet Therapy for Acute Respiratory Distress Syndrome
CM Chen, HC Lu, YT Tung, W Chen
Biomedicines 2020
Revisiting Platelets and Toll-Like Receptors (TLRs): At the Interface of Vascular Immunity and Thrombosis
K Hally, S Fauteux-Daniel, H Hamzeh-Cognasse, P Larsen, F Cognasse
International journal of molecular sciences 2020
Evaluation of Platelet Responses in Transfusion-Related Acute Lung Injury (TRALI)
EA van der Laan, S van der Velden, L Porcelijn, JW Semple, CE van der Schoot, R Kapur
Transfusion Medicine Reviews 2020
Activated αIIbβ3 on platelets mediates flow-dependent NETosis via SLC44A2
A Constantinescu-Bercu, L Grassi, M Frontini, II Salles-Crawley, K Woollard, JT Crawley
eLife 2020
Neutrophil Adaptations upon Recruitment to the Lung: New Concepts and Implications for Homeostasis and Disease
VD Giacalone, C Margaroli, MA Mall, R Tirouvanziam
International journal of molecular sciences 2020
The Role of Neutrophil NETosis in Organ Injury: Novel Inflammatory Cell Death Mechanisms
Z Cahilog, H Zhao, L Wu, A Alam, S Eguchi, H Weng, D Ma
Inflammation 2020
Determination of a “Specific Population Who Could Benefit From Rosuvastatin”: A Secondary Analysis of a Randomized Controlled Trial to Uncover the Novel Value of Rosuvastatin for the Precise Treatment of ARDS
S Zhang, Z Lu, Z Wu, J Xie, Y Yang, H Qiu
Frontiers in Medicine 2020
Animal models of mechanisms of SARS‐CoV‐2 infection and COVID‐19 pathology
SJ Cleary, SC Pitchford, RT Amison, R Carrington, CL Cabrera, M Magnen, MR Looney, E Gray, CP Page
British Journal of Pharmacology 2020
The rationale for a multi-step therapeutic approach based on antivirals, drugs and nutrients with immunomodulatory activity in patients with coronavirus-SARS2-induced disease of different severities
S Fiorino, M Zippi, C Gallo, D Sifo, S Sabbatani, R Manfredi, E Rasciti, L Rasciti, E Giampieri, I Corazza, P Leandri, D de Biase
British Journal of Nutrition 2020
A novel cell-based assay for dynamically detecting neutrophil extracellular traps-induced lung epithelial injuries
D Lv, Y Xu, H Cheng, Y Ke, X Zhang, K Ying
Experimental Cell Research 2020

Lymphatic Flow: A Potential Target in Sepsis-Associated Acute Lung Injury


C Wu, H Li, P Zhang, C Tian, J Luo, W Zhang, S Bhandari, S Jin, Y Hao
Journal of inflammation research 2020
Disease Mechanisms of Perioperative Organ Injury
C Conrad, HK Eltzschig
Anesthesia & Analgesia 2020
Platelet activation in experimental murine neonatal pulmonary hypertension.
Davizon-Castillo P, Allawzi A, Sorrells M, Fisher S, Baltrunaite K, Neeves K, Nozik-Grayck E, DiPaola J, Delaney C
Physiological Reports 2020
Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research.
Bikdeli B, Madhavan MV, Gupta A, Jimenez D, Burton JR, Der Nigoghossian C, Chuich T, Nouri SN, Dreyfus I, Driggin E, Sethi S, Sehgal K, Chatterjee S, Ageno W, Madjid M, Guo Y, Tang LV, Hu Y, Bertoletti L, Giri J, Cushman M, Quéré I, Dimakakos EP, Gibson CM, Lippi G, Favaloro EJ, Fareed J, Tafur AJ, Francese DP, Batra J, Falanga A, Clerkin KJ, Uriel N, Kirtane A, McLintock C, Hunt BJ, Spyropoulos AC, Barnes GD, Eikelboom JW, Weinberg I, Schulman S, Carrier M, Piazza G, Beckman JA, Leon MB, Stone GW, Rosenkranz S, Goldhaber SZ, Parikh SA, Monreal M, Krumholz HM, Konstantinides SV, Weitz JI, Lip GYH
Thrombosis and haemostasis 2020
Anti-Inflammatory and Reactive Oxygen Species Suppression through Aspirin Pretreatment to Treat Hyperoxia-Induced Acute Lung Injury in NF-κB–Luciferase Inducible Transgenic Mice
Chen CM, Tung YT, Wei CH, Lee PY, Chen W
Antioxidants 2020
Extracellular Vesicles: A New Frontier for Research in Acute Respiratory Distress Syndrome.
Mahida RY, Matsumoto S, Matthay MA
American journal of respiratory cell and molecular biology 2020
Three novel prevention, diagnostic, and treatment options for COVID-19 urgently necessitating controlled randomized trials.
Horowitz RI, Freeman PR
Medical Hypotheses 2020
Pretreatment with atorvastatin ameliorates cobra venom factor-induced acute lung inflammation in mice
Guo J, Li M, Yang Y, Zhang L, Zhang LW, Sun QY
BMC Pulmonary Medicine 2020

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts