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Citations to this article

Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury
Mark R. Looney, … , Clifford A. Lowell, Michael A. Matthay
Mark R. Looney, … , Clifford A. Lowell, Michael A. Matthay
Published October 5, 2009
Citation Information: J Clin Invest. 2009;119(11):3450-3461. https://doi.org/10.1172/JCI38432.
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Research Article Pulmonology

Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury

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Abstract

Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-associated mortality in the US. Previously, we established an immune-mediated TRALI mouse model, wherein mice with cognate antigen were challenged with MHC class I mAb. In this study, when mice housed in a rodent, specific pathogen–free barrier room were challenged with MHC I mAb, there was significant protection from TRALI compared with nonbarrier mice. Priming mice with LPS restored lung injury with mAb challenge. Using TLR4-deficient bone marrow chimeras, the priming phenotype was restricted to animals with WT hematopoietic cells, and depletion of either neutrophils or platelets was protective. Both neutrophils and platelets were sequestered in the lungs of mice with TRALI, and retention of platelets was neutrophil dependent. Interestingly, treatment with aspirin prevented lung injury and mortality, but blocking the P selectin or CD11b/CD18 pathways did not. These data suggest a 2-step mechanism of TRALI: priming of hematopoietic cells, followed by vascular deposition of activated neutrophils and platelets that then mediate the severe lung injury. Furthermore, our data offer an explanation for the increased incidence of TRALI in patients with immune priming conditions, and we suggest what we believe to be a novel therapeutic approach.

Authors

Mark R. Looney, John X. Nguyen, Yongmei Hu, Jessica A. Van Ziffle, Clifford A. Lowell, Michael A. Matthay

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Total
Citations: 1 7 5 18 11 24 12 12 12 17 23 18 13 17 16 8 1 215
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2013 (13)

Title and authors Publication Year
Extracellular hemin crisis triggers acute chest syndrome in sickle mice
Samit Ghosh, Olufolake Adisa, Prasanthi Chappa, Fang Tan, Kesmic A. Jackson, David R Archer, Solomon Ofori-Acquah
Journal of Clinical Investigation 2013
Sugar administration is an effective adjunctive therapy in the treatment of Pseudomonas aeruginosa pneumonia
I Bucior, J Abbott, Y Song, MA Matthay, JN Engel
American journal of physiology. Lung cellular and molecular physiology 2013
Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway
B Xiang, G Zhang, L Guo, XA Li, AJ Morris, A Daugherty, SW Whiteheart, SS Smyth, Z Li
Nature Communications 2013
Platelets as cellular effectors of inflammation in vascular diseases
MT Rondina, AS Weyrich, GA Zimmerman
Circulation research 2013
Transfusion-Related Acute Lung Injury: The Work of DAMPs
WG Land
Transfusion Medicine and Hemotherapy 2013
The association between red blood cell and platelet transfusion and subsequently developing idiopathic pneumonia syndrome after hematopoietic stem cell transplantation
LK Vusse, DK Madtes, KA Guthrie, TB Gernsheimer, JR Curtis, TR Watkins
Transfusion 2013
The acute respiratory distress syndrome in 2013
MA Matthay, Y Song, C Bai, KD Jones
Translational Respiratory Medicine 2013
Pharmacological interventions in acute respiratory distress syndrome
A Roch, S Hraiech, S Dizier, L Papazian
Annals of Intensive Care 2013
NET balancing: a problem in inflammatory lung diseases
OZ Cheng, N Palaniyar
Frontiers in immunology 2013
Role of diabetes in the development of acute respiratory distress syndrome
S Yu, DC Christiani, BT Thompson, EK Bajwa, MN Gong
Critical Care Medicine 2013
Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice
CL Abram, GL Roberge, LI Pao, BG Neel, CA Lowell
Immunity 2013
Platelets are dominant contributors to hypercoagulability after injury
JN Harr, EE Moore, TL Chin, A Ghasabyan, E Gonzalez, MV Wohlauer, A Banerjee, CC Silliman, A Sauaia
The journal of trauma and acute care surgery 2013
Antiplatelet therapy is associated with decreased transfusion-associated risk of lung dysfunction, multiple organ failure, and mortality in trauma patients
JN Harr, EE Moore, J Johnson, TL Chin, MV Wohlauer, R Maier, J Cuschieri, J Sperry, A Banerjee, CC Silliman, A Sauaia
Critical Care Medicine 2013

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