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Citations to this article

Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury
Mark R. Looney, … , Clifford A. Lowell, Michael A. Matthay
Mark R. Looney, … , Clifford A. Lowell, Michael A. Matthay
Published October 5, 2009
Citation Information: J Clin Invest. 2009;119(11):3450-3461. https://doi.org/10.1172/JCI38432.
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Research Article Pulmonology

Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury

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Abstract

Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-associated mortality in the US. Previously, we established an immune-mediated TRALI mouse model, wherein mice with cognate antigen were challenged with MHC class I mAb. In this study, when mice housed in a rodent, specific pathogen–free barrier room were challenged with MHC I mAb, there was significant protection from TRALI compared with nonbarrier mice. Priming mice with LPS restored lung injury with mAb challenge. Using TLR4-deficient bone marrow chimeras, the priming phenotype was restricted to animals with WT hematopoietic cells, and depletion of either neutrophils or platelets was protective. Both neutrophils and platelets were sequestered in the lungs of mice with TRALI, and retention of platelets was neutrophil dependent. Interestingly, treatment with aspirin prevented lung injury and mortality, but blocking the P selectin or CD11b/CD18 pathways did not. These data suggest a 2-step mechanism of TRALI: priming of hematopoietic cells, followed by vascular deposition of activated neutrophils and platelets that then mediate the severe lung injury. Furthermore, our data offer an explanation for the increased incidence of TRALI in patients with immune priming conditions, and we suggest what we believe to be a novel therapeutic approach.

Authors

Mark R. Looney, John X. Nguyen, Yongmei Hu, Jessica A. Van Ziffle, Clifford A. Lowell, Michael A. Matthay

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Total
Citations: 1 7 5 18 11 24 12 12 12 17 23 18 13 17 16 8 1 215
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2018 (12)

Title and authors Publication Year
Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injury
R Kapur, M Kim, J Rebetz, B Hallström, JT Björkman, A Takabe-French, N Kim, J Liu, S Shanmugabhavananthan, S Milosevic, MJ McVey, ER Speck, JW Semple
Blood Advances 2018
The Pathogenic Involvement of Neutrophils in Acute Respiratory Distress Syndrome and Transfusion-Related Acute Lung Injury
J Rebetz, JW Semple, R Kapur
Transfusion Medicine and Hemotherapy 2018
Measuring and interpreting platelet-leukocyte aggregates
M Finsterbusch, WC Schrottmaier, JB Kral-Pointner, M Salzmann, A Assinger
Platelets 2018
Amicus or Adversary Revisited: Platelets in Acute Lung Injury and Acute Respiratory Distress Syndrome
EA Middleton, MT Rondina, H Schwertz, GA Zimmerman
American journal of respiratory cell and molecular biology 2018
Early Intravascular Events Are Associated with Development of Acute Respiratory Distress Syndrome. A Substudy of the LIPS-A Clinical Trial
RE Abdulnour, T Gunderson, I Barkas, JY Timmons, C Barnig, M Gong, DJ Kor, O Gajic, D Talmor, RE Carter, BD Levy
American journal of respiratory and critical care medicine 2018
Inhibition of IP6K1 suppresses neutrophil-mediated pulmonary damage in bacterial pneumonia
Q Hou, F Liu, A Chakraborty, Y Jia, A Prasad, H Yu, L Zhao, K Ye, SH Snyder, Y Xu, HR Luo
Science Translational Medicine 2018
Role of Platelets in Leukocyte Recruitment and Resolution of Inflammation
J Rossaint, A Margraf, A Zarbock
Frontiers in immunology 2018
Capturing the multifactorial nature of ARDS – “Two‐hit” approach to model murine acute lung injury
S Hoegl, N Burns, M Angulo, D Francis, CM Osborne, TW Mills, MR Blackburn, HK Eltzschig, CU Vohwinkel
Physiological Reports 2018
TLR3 Regulated Poly I:C-Induced Neutrophil Extracellular Traps and Acute Lung Injury Partly Through p38 MAP Kinase
T Gan, Y Yang, F Hu, X Chen, J Zhou, Y Li, Y Xu, H Wang, Y Chen, M Zhang
Frontiers in microbiology 2018
Aspirin use and long-term rates of sepsis: A population-based cohort study
J Hsu, JP Donnelly, NS Chaudhary, JX Moore, MM Safford, J Kim, HE Wang, PH Wu
PloS one 2018
Protectin DX Exhibits Protective Effects in Mouse Model of Lipopolysaccharide-Induced Acute Lung Injury.
Tan W, Chen L, Wang YX, Hu LS, Xiong W, Shang Y, Yao SL
Chinese Medical Journal 2018
Platelet transfusion increases risk for acute respiratory distress syndrome in non-massively transfused blunt trauma patients.
Kasotakis G, Starr N, Nelson E, Sarkar B, Burke PA, Remick DG, Tompkins RG
2018

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