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Citations to this article

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload
Vera Niederkofler, … , Rishard Salie, Silvia Arber
Vera Niederkofler, … , Rishard Salie, Silvia Arber
Published August 1, 2005
Citation Information: J Clin Invest. 2005;115(8):2180-2186. https://doi.org/10.1172/JCI25683.
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Research Article Genetics Article has an altmetric score of 10

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload

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Abstract

Iron homeostasis plays a critical role in many physiological processes, notably synthesis of heme proteins. Dietary iron sensing and inflammation converge in the control of iron absorption and retention by regulating the expression of hepcidin, a regulator of the iron exporter ferroportin. Human mutations in the glycosylphosphatidylinositol-anchored protein hemojuvelin (HJV; also known as RGMc and HFE2) cause juvenile hemochromatosis, a severe iron overload disease, but the way in which HJV intersects with the iron regulatory network has been unclear. Here we show that, within the liver, mouse Hjv is selectively expressed by periportal hepatocytes and also that Hjv-mutant mice exhibit iron overload as well as a dramatic decrease in hepcidin expression. Our findings define a key role for Hjv in dietary iron sensing and also reveal that cytokine-induced inflammation regulates hepcidin expression through an Hjv-independent pathway.

Authors

Vera Niederkofler, Rishard Salie, Silvia Arber

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 2 2 1 4 5 4 7 10 9 5 6 10 10 13 16 21 21 11 8 9 1 175
Citation information
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Citations to this article in year 2022 (4)

Title and authors Publication Year
Effects of Excess Iron on the Retina: Insights From Clinical Cases and Animal Models of Iron Disorders.
Shahandeh A, Bui BV, Finkelstein DI, Nguyen CTO
Frontiers in neuroscience 2022
Role of Iron in Aging Related Diseases
Chen WJ, Kung GP, Gnana-Prakasam JP
Antioxidants 2022
Heart Ferroportin Protein Content Is Regulated by Heart Iron Concentration and Systemic Hepcidin Expression
Berezovsky B, Frýdlová J, Gurieva I, Rogalsky DW, Vokurka M, Krijt J
International journal of molecular sciences 2022
Hemojuvelin deficiency promotes liver mitochondrial dysfunction and predisposes mice to hepatocellular carcinoma.
Allameh A, Hüttmann N, Charlebois E, Katsarou A, Gu W, Gkouvatsos K, Pasini E, Bhat M, Minic Z, Berezovski M, Guido M, Fillebeen C, Pantopoulos K
2022

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ISSN: 0021-9738 (print), 1558-8238 (online)

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