Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload
Vera Niederkofler, … , Rishard Salie, Silvia Arber
Vera Niederkofler, … , Rishard Salie, Silvia Arber
Published August 1, 2005
Citation Information: J Clin Invest. 2005;115(8):2180-2186. https://doi.org/10.1172/JCI25683.
View: Text | PDF
Research Article Genetics Article has an altmetric score of 10

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload

  • Text
  • PDF
Abstract

Iron homeostasis plays a critical role in many physiological processes, notably synthesis of heme proteins. Dietary iron sensing and inflammation converge in the control of iron absorption and retention by regulating the expression of hepcidin, a regulator of the iron exporter ferroportin. Human mutations in the glycosylphosphatidylinositol-anchored protein hemojuvelin (HJV; also known as RGMc and HFE2) cause juvenile hemochromatosis, a severe iron overload disease, but the way in which HJV intersects with the iron regulatory network has been unclear. Here we show that, within the liver, mouse Hjv is selectively expressed by periportal hepatocytes and also that Hjv-mutant mice exhibit iron overload as well as a dramatic decrease in hepcidin expression. Our findings define a key role for Hjv in dietary iron sensing and also reveal that cytokine-induced inflammation regulates hepcidin expression through an Hjv-independent pathway.

Authors

Vera Niederkofler, Rishard Salie, Silvia Arber

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 1 2 1 4 5 4 7 10 9 5 6 10 10 13 16 21 21 11 8 9 1 174
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2009 (21)

Title and authors Publication Year
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Genetic mechanisms and modifying factors in hereditary hemochromatosis
G Weiss
Nature Reviews Gastroenterology & Hepatology 2009
Iron sequestration and anemia of inflammation
T Ganz, E Nemeth
Seminars in Hematology 2009
Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes
G Ramey, JC Deschemin, S Vaulont
Haematologica 2009
BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
B Andriopoulos, E Corradini, Y Xia, SA Faasse, S Chen, L Grgurevic, MD Knutson, A Pietrangelo, S Vukicevic, HY Lin, JL Babitt
Nature Genetics 2009
Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli
H Huang, M Constante, A Layoun, MM Santos
Blood 2009
Iron metabolism in thalassemia and sickle cell disease
R Mariani, P Trombini, M Pozzi, A Piperno
Mediterranean journal of hematology and infectious diseases 2009
The role of hepcidin in iron metabolism
E Nemeth, T Ganz
Acta Haematologica 2009
Hepcidin modulation in human diseases: from research to clinic
A Piperno, R Mariani, P Trombini, D Girelli
World journal of gastroenterology : WJG 2009
A general map of iron metabolism and tissue-specific subnetworks
V Hower, P Mendes, FM Torti, R Laubenbacher, S Akman, V Shulaev, SV Torti
Molecular BioSystems 2009
Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis
E Corradini, C Garuti, G Montosi, P Ventura, B Andriopoulos, HY Lin, A Pietrangelo, JL Babitt
Gastroenterology 2009
Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression
AS Zhang, F Yang, J Wang, H Tsukamoto, CA Enns
The Journal of biological chemistry 2009
Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis
AJ Ramsay, JD Hooper, AR Folgueras, G Velasco, C López-Otín
Haematologica 2009
Iron homeostasis: recently identified proteins provide insight into novel control mechanisms
AS Zhang, CA Enns
The Journal of biological chemistry 2009
Molecular biology, genetics and biochemistry of the repulsive guidance molecule family
CJ Severyn, U Shinde, P Rotwein
Biochemical Journal 2009
Lack of the bone morphogenetic protein BMP6 induces massive iron overload
D Meynard, L Kautz, V Darnaud, F Canonne-Hergaux, H Coppin, MP Roth
Nature Genetics 2009
THE RGM/DRAGON FAMILY OF BMP CO-RECEPTORS
E Corradini, JL Babitt, HY Lin
Cytokine & Growth Factor Reviews 2009
Neogenin Regulates Skeletal Myofiber Size and Focal Adhesion Kinase and Extracellular Signal-regulated Kinase Activities In Vivo and In Vitro
GU Bae, YJ Yang, G Jiang, M Hong, HJ Lee, M Tessier-Lavigne, JS Kang, RS Krauss, RK Assoian
Molecular biology of the cell 2009
Molecular mechanisms of normal iron homeostasis
AS Zhang, CA Enns
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2009
Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD
G Casanovas, K Mleczko-Sanecka, S Altamura, MW Hentze, MU Muckenthaler
Journal of Molecular Medicine 2009
BMP6 orchestrates iron metabolism
C Camaschella
Nature Genetics 2009

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 13 patents
Referenced in 2 Wikipedia pages
Highlighted by 1 platforms
79 readers on Mendeley
See more details