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Citations to this article

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload
Vera Niederkofler, … , Rishard Salie, Silvia Arber
Vera Niederkofler, … , Rishard Salie, Silvia Arber
Published August 1, 2005
Citation Information: J Clin Invest. 2005;115(8):2180-2186. https://doi.org/10.1172/JCI25683.
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Research Article Genetics Article has an altmetric score of 10

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload

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Abstract

Iron homeostasis plays a critical role in many physiological processes, notably synthesis of heme proteins. Dietary iron sensing and inflammation converge in the control of iron absorption and retention by regulating the expression of hepcidin, a regulator of the iron exporter ferroportin. Human mutations in the glycosylphosphatidylinositol-anchored protein hemojuvelin (HJV; also known as RGMc and HFE2) cause juvenile hemochromatosis, a severe iron overload disease, but the way in which HJV intersects with the iron regulatory network has been unclear. Here we show that, within the liver, mouse Hjv is selectively expressed by periportal hepatocytes and also that Hjv-mutant mice exhibit iron overload as well as a dramatic decrease in hepcidin expression. Our findings define a key role for Hjv in dietary iron sensing and also reveal that cytokine-induced inflammation regulates hepcidin expression through an Hjv-independent pathway.

Authors

Vera Niederkofler, Rishard Salie, Silvia Arber

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 1 2 1 4 5 4 7 10 9 5 6 10 10 13 16 21 21 11 8 9 1 174
Citation information
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Citations to this article in year 2015 (6)

Title and authors Publication Year
The small molecule ferristatin II induces hepatic hepcidin expression in vivo and in vitro
AA Alkhateeb, PD Buckett, AM Gardeck, J Kim, SL Byrne, PG Fraenkel, M Wessling-Resnick
AJP Gastrointestinal and Liver Physiology 2015
Regulation of Iron Metabolism by Hepcidin under Conditions of Inflammation
PJ Schmidt
The Journal of biological chemistry 2015
SLC39A14 Is Required for the Development of Hepatocellular Iron Overload in Murine Models of Hereditary Hemochromatosis
S Jenkitkasemwong, CY Wang, R Coffey, W Zhang, A Chan, T Biel, JS Kim, S Hojyo, T Fukada, MD Knutson
Cell Metabolism 2015
Bmp6 Expression in Murine Liver Non Parenchymal Cells: A Mechanism to Control their High Iron Exporter Activity and Protect Hepatocytes from Iron Overload?
M Rausa, A Pagani, A Nai, A Campanella, ME Gilberti, P Apostoli, C Camaschella, L Silvestri, K Pantopoulos
PloS one 2015
Iron-overload injury and cardiomyopathy in acquired and genetic models is attenuated by resveratrol therapy
SK Das, W Wang, P Zhabyeyev, R Basu, B McLean, D Fan, N Parajuli, J DesAulniers, VB Patel, RJ Hajjar, JR Dyck, Z Kassiri, GY Oudit
Scientific Reports 2015
Anti-repulsive Guidance Molecule C (RGMc) Antibodies Increases Serum Iron in Rats and Cynomolgus Monkeys by Hepcidin Downregulation
P Böser, D Seemann, MJ Liguori, L Fan, L Huang, M Hafner, A Popp, BK Mueller
The AAPS Journal 2015

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