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Citations to this article

Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9
Terry K. Means, … , Douglas T. Golenbock, Andrew D. Luster
Terry K. Means, … , Douglas T. Golenbock, Andrew D. Luster
Published February 1, 2005
Citation Information: J Clin Invest. 2005;115(2):407-417. https://doi.org/10.1172/JCI23025.
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Article Autoimmunity Article has an altmetric score of 14

Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9

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Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by pathogenic autoantibodies against nucleoproteins and DNA. Here we show that DNA-containing immune complexes (ICs) within lupus serum (SLE-ICs), but not protein-containing ICs from other autoimmune rheumatic diseases, stimulates plasmacytoid DCs (PDCs) to produce cytokines and chemokines via a cooperative interaction between Toll-like receptor 9 (TLR9) and FcγRIIa (CD32). SLE-ICs transiently colocalized to a subcellular compartment containing CD32 and TLR9, and CD32+, but not CD32–, PDCs internalized and responded to SLE-ICs. Our findings demonstrate a novel functional interaction between Fc receptors and TLRs, defining a pathway in which CD32 delivers SLE-ICs to intracellular lysosomes containing TLR9, inducing a signaling cascade leading to PDC activation. These data demonstrate that endogenous DNA-containing autoantibody complexes found in the serum of patients with SLE activate the innate immune system and suggest a novel mechanism whereby these ICs contribute to the pathogenesis of this autoimmune disease.

Authors

Terry K. Means, Eicke Latz, Fumitaka Hayashi, Mandakolathur R. Murali, Douglas T. Golenbock, Andrew D. Luster

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 3 14 10 13 16 9 21 18 17 14 22 21 17 24 18 26 22 13 6 7 11 322
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2005 (11)

Title and authors Publication Year
BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation
BD Medoff, E Seung, JC Wain, TK Means, GS Campanella, SA Islam, SY Thomas, LC Ginns, N Grabie, AH Lichtman, AM Tager, AD Luster
Journal of Experimental Medicine 2005
Dendritic cells, Fc{gamma} receptors, and Toll-like receptors: potential allies in the battle against rheumatoid arthritis
TR Radstake, AW van Lieshout, PL van Riel, WB van Berg, GJ Adema
Annals of the rheumatic diseases 2005
Bacterial interactions with cells of the intestinal mucosa: Toll-like receptors and NOD2
E Cario
Gut 2005
Manifold Mechanisms of Toll-Like Receptor-Ligand Recognition
KJ Ishii, C Coban, S Akira
Journal of Clinical Immunology 2005
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement
CM Lau, C Broughton, AS Tabor, S Akira, RA Flavell, MJ Mamula, SR Christensen, MJ Shlomchik, GA Viglianti, IR Rifkin, A Marshak-Rothstein
Journal of Experimental Medicine 2005
Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8
J Vollmer, S Tluk, C Schmitz, S Hamm, M Jurk, A Forsbach, S Akira, KM Kelly, WH Reeves, S Bauer, AM Krieg
Journal of Experimental Medicine 2005
Molecular mechanisms of autoimmunity triggered by microbial infection
HJ Anders, D Zecher, RD Pawar, PS Patole
Arthritis Research & Therapy 2005
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
FJ Barrat, T Meeker, J Gregorio, JH Chan, S Uematsu, S Akira, B Chang, O Duramad, RL Coffman
Journal of Experimental Medicine 2005
Interferon pathway activation in systemic lupus erythematosus
MK Crow
Current Rheumatology Reports 2005
From the Th1/Th2 Paradigm towards a Toll-Like Receptor/T-Helper Bias
MG Netea, JW der Meer, RP Sutmuller, GJ Adema, BJ Kullberg
Antimicrobial agents and chemotherapy 2005
New insights into the pathogenesis of systemic lupus erythematosus.
Kyttaris VC, Katsiari CG, Juang YT, Tsokos GC
Current Rheumatology Reports 2005

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