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Citations to this article

Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9
Terry K. Means, … , Douglas T. Golenbock, Andrew D. Luster
Terry K. Means, … , Douglas T. Golenbock, Andrew D. Luster
Published February 1, 2005
Citation Information: J Clin Invest. 2005;115(2):407-417. https://doi.org/10.1172/JCI23025.
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Article Autoimmunity Article has an altmetric score of 14

Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9

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Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by pathogenic autoantibodies against nucleoproteins and DNA. Here we show that DNA-containing immune complexes (ICs) within lupus serum (SLE-ICs), but not protein-containing ICs from other autoimmune rheumatic diseases, stimulates plasmacytoid DCs (PDCs) to produce cytokines and chemokines via a cooperative interaction between Toll-like receptor 9 (TLR9) and FcγRIIa (CD32). SLE-ICs transiently colocalized to a subcellular compartment containing CD32 and TLR9, and CD32+, but not CD32–, PDCs internalized and responded to SLE-ICs. Our findings demonstrate a novel functional interaction between Fc receptors and TLRs, defining a pathway in which CD32 delivers SLE-ICs to intracellular lysosomes containing TLR9, inducing a signaling cascade leading to PDC activation. These data demonstrate that endogenous DNA-containing autoantibody complexes found in the serum of patients with SLE activate the innate immune system and suggest a novel mechanism whereby these ICs contribute to the pathogenesis of this autoimmune disease.

Authors

Terry K. Means, Eicke Latz, Fumitaka Hayashi, Mandakolathur R. Murali, Douglas T. Golenbock, Andrew D. Luster

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 3 14 10 13 16 9 21 18 17 14 22 21 17 24 18 26 22 13 6 7 11 322
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2006 (7)

Title and authors Publication Year
Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjögren's syndrome
JE Gottenberg, N Cagnard, C Lucchesi, F Letourneur, S Mistou, T Lazure, S Jacques, N Ba, M Ittah, C Lepajolec, M Labetoulle, M Ardizzone, J Sibilia, C Fournier, G Chiocchia, X Mariette
Proceedings of the National Academy of Sciences 2006
Plasmacytoid dendritic cells of melanoma patients present exogenous proteins to CD4+ T cells after Fc gamma RII-mediated uptake
D Benitez-Ribas, GJ Adema, G Winkels, IS Klasen, CJ Punt, CG Figdor, IJ de Vries
Journal of Experimental Medicine 2006
Toll-like receptors in systemic autoimmune disease
A Marshak-Rothstein
Nature Reviews Immunology 2006
The role of toll-like receptors in systemic lupus erythematosus
AH Rahman, RA Eisenberg
Springer Seminars in Immunopathology 2006
All is not Toll: new pathways in DNA recognition
H Wagner, S Bauer
Journal of Experimental Medicine 2006
FcγRII and multi-system autoimmune disease
NC van de Velde, PL Mottram, PM Hogarth
Springer Seminars in Immunopathology 2006
B-cell-targeted therapy for systemic lupus erythematosus.
Sabahi R, Anolik JH
Drugs 2006

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