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ResearchIn-Press PreviewCell biologyHepatologyMetabolism
Open Access | 
10.1172/JCI205758
Epigenetic regulation of DOT1L methyltransferase activityremodels lipid metabolism to alleviate ferroptosis-induced liver injury
Jia-ming Hu,1 Shuo Liu,2 Zheng-ze Pan,3 Yi-jia Gao,4 Wei-wei Cui,3 Xiao Zhuang,3 Rong Wang,5 Ya-jing Han,5 Jia-xing Liu,6 Xiang-chuang Fan,6 Dan-dan Song,3 Zi-yang Zhang,6 Wan-yang Sun,5 Zong-li Zhang,1 Rong-rong He,5 Yun-fei Xu,1 Wei Gu,7 Chang Pan,8 and Bo Chu3
1Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
2Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China
3Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
4Department of Neurology, Aerospace Center Hospital, School of Life, Beijing Institute of Technology, Beijing, China
5State Key Laboratory of Bioactive Molecules and Druggability Assessment/Gua, College of Pharmacy, Jinan University, Guangzhou, China
6Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University, Jinan, China
7Institute for Cancer Genetics, and Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University, New York, United States of America
8Department of Emergency and Chest Pain Center, Shandong Provincial Clinical, Qilu Hospital of Shandong University, Jinan, China
Find articles by Hu, J. in: PubMed | Google Scholar
1Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
2Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China
3Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
4Department of Neurology, Aerospace Center Hospital, School of Life, Beijing Institute of Technology, Beijing, China
5State Key Laboratory of Bioactive Molecules and Druggability Assessment/Gua, College of Pharmacy, Jinan University, Guangzhou, China
6Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University, Jinan, China
7Institute for Cancer Genetics, and Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University, New York, United States of America
8Department of Emergency and Chest Pain Center, Shandong Provincial Clinical, Qilu Hospital of Shandong University, Jinan, China
Find articles by Liu, S. in: PubMed | Google Scholar
1Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
2Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China
3Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
4Department of Neurology, Aerospace Center Hospital, School of Life, Beijing Institute of Technology, Beijing, China
5State Key Laboratory of Bioactive Molecules and Druggability Assessment/Gua, College of Pharmacy, Jinan University, Guangzhou, China
6Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University, Jinan, China
7Institute for Cancer Genetics, and Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University, New York, United States of America
8Department of Emergency and Chest Pain Center, Shandong Provincial Clinical, Qilu Hospital of Shandong University, Jinan, China
Find articles by Pan, Z. in: PubMed | Google Scholar
1Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
2Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China
3Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
4Department of Neurology, Aerospace Center Hospital, School of Life, Beijing Institute of Technology, Beijing, China
5State Key Laboratory of Bioactive Molecules and Druggability Assessment/Gua, College of Pharmacy, Jinan University, Guangzhou, China
6Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University, Jinan, China
7Institute for Cancer Genetics, and Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University, New York, United States of America
8Department of Emergency and Chest Pain Center, Shandong Provincial Clinical, Qilu Hospital of Shandong University, Jinan, China
Find articles by Gao, Y. in: PubMed | Google Scholar
1Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
2Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China
3Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
4Department of Neurology, Aerospace Center Hospital, School of Life, Beijing Institute of Technology, Beijing, China
5State Key Laboratory of Bioactive Molecules and Druggability Assessment/Gua, College of Pharmacy, Jinan University, Guangzhou, China
6Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University, Jinan, China
7Institute for Cancer Genetics, and Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University, New York, United States of America
8Department of Emergency and Chest Pain Center, Shandong Provincial Clinical, Qilu Hospital of Shandong University, Jinan, China
Find articles by Cui, W. in: PubMed | Google Scholar
1Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
2Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China
3Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
4Department of Neurology, Aerospace Center Hospital, School of Life, Beijing Institute of Technology, Beijing, China
5State Key Laboratory of Bioactive Molecules and Druggability Assessment/Gua, College of Pharmacy, Jinan University, Guangzhou, China
6Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University, Jinan, China
7Institute for Cancer Genetics, and Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University, New York, United States of America
8Department of Emergency and Chest Pain Center, Shandong Provincial Clinical, Qilu Hospital of Shandong University, Jinan, China
Find articles by Zhuang, X. in: PubMed | Google Scholar
1Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
2Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China
3Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
4Department of Neurology, Aerospace Center Hospital, School of Life, Beijing Institute of Technology, Beijing, China
5State Key Laboratory of Bioactive Molecules and Druggability Assessment/Gua, College of Pharmacy, Jinan University, Guangzhou, China
6Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University, Jinan, China
7Institute for Cancer Genetics, and Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University, New York, United States of America
8Department of Emergency and Chest Pain Center, Shandong Provincial Clinical, Qilu Hospital of Shandong University, Jinan, China
Find articles by Wang, R. in: PubMed | Google Scholar
1Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
2Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China
3Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
4Department of Neurology, Aerospace Center Hospital, School of Life, Beijing Institute of Technology, Beijing, China
5State Key Laboratory of Bioactive Molecules and Druggability Assessment/Gua, College of Pharmacy, Jinan University, Guangzhou, China
6Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University, Jinan, China
7Institute for Cancer Genetics, and Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University, New York, United States of America
8Department of Emergency and Chest Pain Center, Shandong Provincial Clinical, Qilu Hospital of Shandong University, Jinan, China
Find articles by Han, Y. in: PubMed | Google Scholar
1Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
2Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China
3Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
4Department of Neurology, Aerospace Center Hospital, School of Life, Beijing Institute of Technology, Beijing, China
5State Key Laboratory of Bioactive Molecules and Druggability Assessment/Gua, College of Pharmacy, Jinan University, Guangzhou, China
6Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University, Jinan, China
7Institute for Cancer Genetics, and Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University, New York, United States of America
8Department of Emergency and Chest Pain Center, Shandong Provincial Clinical, Qilu Hospital of Shandong University, Jinan, China
Find articles by Liu, J. in: PubMed | Google Scholar
1Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
2Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China
3Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
4Department of Neurology, Aerospace Center Hospital, School of Life, Beijing Institute of Technology, Beijing, China
5State Key Laboratory of Bioactive Molecules and Druggability Assessment/Gua, College of Pharmacy, Jinan University, Guangzhou, China
6Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University, Jinan, China
7Institute for Cancer Genetics, and Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University, New York, United States of America
8Department of Emergency and Chest Pain Center, Shandong Provincial Clinical, Qilu Hospital of Shandong University, Jinan, China
Find articles by Fan, X. in: PubMed | Google Scholar
1Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
2Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China
3Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
4Department of Neurology, Aerospace Center Hospital, School of Life, Beijing Institute of Technology, Beijing, China
5State Key Laboratory of Bioactive Molecules and Druggability Assessment/Gua, College of Pharmacy, Jinan University, Guangzhou, China
6Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University, Jinan, China
7Institute for Cancer Genetics, and Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University, New York, United States of America
8Department of Emergency and Chest Pain Center, Shandong Provincial Clinical, Qilu Hospital of Shandong University, Jinan, China
Find articles by Song, D. in: PubMed | Google Scholar
1Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
2Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China
3Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
4Department of Neurology, Aerospace Center Hospital, School of Life, Beijing Institute of Technology, Beijing, China
5State Key Laboratory of Bioactive Molecules and Druggability Assessment/Gua, College of Pharmacy, Jinan University, Guangzhou, China
6Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University, Jinan, China
7Institute for Cancer Genetics, and Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University, New York, United States of America
8Department of Emergency and Chest Pain Center, Shandong Provincial Clinical, Qilu Hospital of Shandong University, Jinan, China
Find articles by Zhang, Z. in: PubMed | Google Scholar
1Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
2Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China
3Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
4Department of Neurology, Aerospace Center Hospital, School of Life, Beijing Institute of Technology, Beijing, China
5State Key Laboratory of Bioactive Molecules and Druggability Assessment/Gua, College of Pharmacy, Jinan University, Guangzhou, China
6Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University, Jinan, China
7Institute for Cancer Genetics, and Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University, New York, United States of America
8Department of Emergency and Chest Pain Center, Shandong Provincial Clinical, Qilu Hospital of Shandong University, Jinan, China
Find articles by Sun, W. in: PubMed | Google Scholar
1Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
2Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China
3Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
4Department of Neurology, Aerospace Center Hospital, School of Life, Beijing Institute of Technology, Beijing, China
5State Key Laboratory of Bioactive Molecules and Druggability Assessment/Gua, College of Pharmacy, Jinan University, Guangzhou, China
6Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University, Jinan, China
7Institute for Cancer Genetics, and Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University, New York, United States of America
8Department of Emergency and Chest Pain Center, Shandong Provincial Clinical, Qilu Hospital of Shandong University, Jinan, China
Find articles by Zhang, Z. in: PubMed | Google Scholar
1Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
2Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China
3Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
4Department of Neurology, Aerospace Center Hospital, School of Life, Beijing Institute of Technology, Beijing, China
5State Key Laboratory of Bioactive Molecules and Druggability Assessment/Gua, College of Pharmacy, Jinan University, Guangzhou, China
6Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University, Jinan, China
7Institute for Cancer Genetics, and Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University, New York, United States of America
8Department of Emergency and Chest Pain Center, Shandong Provincial Clinical, Qilu Hospital of Shandong University, Jinan, China
Find articles by He, R. in: PubMed | Google Scholar
1Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
2Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China
3Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
4Department of Neurology, Aerospace Center Hospital, School of Life, Beijing Institute of Technology, Beijing, China
5State Key Laboratory of Bioactive Molecules and Druggability Assessment/Gua, College of Pharmacy, Jinan University, Guangzhou, China
6Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University, Jinan, China
7Institute for Cancer Genetics, and Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University, New York, United States of America
8Department of Emergency and Chest Pain Center, Shandong Provincial Clinical, Qilu Hospital of Shandong University, Jinan, China
Find articles by Xu, Y. in: PubMed | Google Scholar
1Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
2Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China
3Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
4Department of Neurology, Aerospace Center Hospital, School of Life, Beijing Institute of Technology, Beijing, China
5State Key Laboratory of Bioactive Molecules and Druggability Assessment/Gua, College of Pharmacy, Jinan University, Guangzhou, China
6Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University, Jinan, China
7Institute for Cancer Genetics, and Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University, New York, United States of America
8Department of Emergency and Chest Pain Center, Shandong Provincial Clinical, Qilu Hospital of Shandong University, Jinan, China
Find articles by Gu, W. in: PubMed | Google Scholar
1Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
2Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China
3Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
4Department of Neurology, Aerospace Center Hospital, School of Life, Beijing Institute of Technology, Beijing, China
5State Key Laboratory of Bioactive Molecules and Druggability Assessment/Gua, College of Pharmacy, Jinan University, Guangzhou, China
6Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University, Jinan, China
7Institute for Cancer Genetics, and Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University, New York, United States of America
8Department of Emergency and Chest Pain Center, Shandong Provincial Clinical, Qilu Hospital of Shandong University, Jinan, China
Find articles by Pan, C. in: PubMed | Google Scholar
1Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
2Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China
3Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
4Department of Neurology, Aerospace Center Hospital, School of Life, Beijing Institute of Technology, Beijing, China
5State Key Laboratory of Bioactive Molecules and Druggability Assessment/Gua, College of Pharmacy, Jinan University, Guangzhou, China
6Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University, Jinan, China
7Institute for Cancer Genetics, and Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University, New York, United States of America
8Department of Emergency and Chest Pain Center, Shandong Provincial Clinical, Qilu Hospital of Shandong University, Jinan, China
Find articles by Chu, B. in: PubMed | Google Scholar
Published November 12, 2026 - More info
Copyright © 2026, Hu et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)