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ResearchIn-Press PreviewCell biologyVascular biology
Open Access | 
10.1172/JCI203386
C/EBP-β-mediated upregulation of CaV1.2 calcium channel increases arterial constriction in mice with ibrutinib-associated hypertension
Ludan Zhang,1 Shumin Yin,1 Wei Hou,1 Dan Yang,1 Yiyuan Jia,1 Yun Liu,1 Yan Wang,1 Sirui Zhao,1 Xiaoyan Gao,2 Xiaolin Sun,2 Xiao Lu,3 Jianyong Li,4 Ming Chu,2 Xiaoqing Xiong,1 Huayuan Zhu,4 and Juejin Wang1
1Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China
2The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China
3Department of Rehabilitation, Jiangsu Province People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
4Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Find articles by Zhang, L. in: PubMed | Google Scholar
1Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China
2The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China
3Department of Rehabilitation, Jiangsu Province People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
4Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Find articles by Yin, S. in: PubMed | Google Scholar
1Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China
2The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China
3Department of Rehabilitation, Jiangsu Province People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
4Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Find articles by Hou, W. in: PubMed | Google Scholar
1Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China
2The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China
3Department of Rehabilitation, Jiangsu Province People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
4Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Find articles by Yang, D. in: PubMed | Google Scholar
1Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China
2The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China
3Department of Rehabilitation, Jiangsu Province People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
4Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Find articles by Jia, Y. in: PubMed | Google Scholar
1Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China
2The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China
3Department of Rehabilitation, Jiangsu Province People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
4Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Find articles by Liu, Y. in: PubMed | Google Scholar
1Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China
2The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China
3Department of Rehabilitation, Jiangsu Province People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
4Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Find articles by Wang, Y. in: PubMed | Google Scholar
1Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China
2The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China
3Department of Rehabilitation, Jiangsu Province People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
4Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Find articles by Zhao, S. in: PubMed | Google Scholar
1Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China
2The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China
3Department of Rehabilitation, Jiangsu Province People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
4Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Find articles by Gao, X. in: PubMed | Google Scholar
1Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China
2The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China
3Department of Rehabilitation, Jiangsu Province People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
4Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Find articles by Sun, X. in: PubMed | Google Scholar
1Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China
2The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China
3Department of Rehabilitation, Jiangsu Province People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
4Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Find articles by Lu, X. in: PubMed | Google Scholar
1Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China
2The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China
3Department of Rehabilitation, Jiangsu Province People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
4Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Find articles by Li, J. in: PubMed | Google Scholar
1Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China
2The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China
3Department of Rehabilitation, Jiangsu Province People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
4Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Find articles by Chu, M. in: PubMed | Google Scholar
1Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China
2The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China
3Department of Rehabilitation, Jiangsu Province People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
4Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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1Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China
2The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China
3Department of Rehabilitation, Jiangsu Province People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
4Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Find articles by Zhu, H. in: PubMed | Google Scholar
1Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China
2The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China
3Department of Rehabilitation, Jiangsu Province People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
4Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Find articles by Wang, J. in: PubMed | Google Scholar
Published November 12, 2026 - More info
Copyright © 2026, Zhang et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)