Go to
JCI Insight
Citations to this article
Lucia A. de Jesus, … , P. Reed Larsen, Antonio C. Bianco
Published November 1, 2001
Citation Information: J Clin Invest. 2001;108(9):1379-1385. https://doi.org/10.1172/JCI13803.
Citation Information: J Clin Invest. 2001;108(9):1379-1385. https://doi.org/10.1172/JCI13803.
Abstract
Type 2 iodothyronine deiodinase (D2) is a selenoenzyme, the product of the recently cloned cAMP-dependent Dio2 gene, which increases 10- to 50-fold during cold stress only in brown adipose tissue (BAT). Here we report that despite a normal plasma 3,5,3′-triiodothyronine (T3) concentration, cold-exposed mice with targeted disruption of the Dio2 gene (Dio2–/–) become hypothermic due to impaired BAT thermogenesis and survive by compensatory shivering with consequent acute weight loss. This occurs despite normal basal mitochondrial uncoupling protein 1 (UCP1) concentration. In Dio2–/– brown adipocytes, the acute norepinephrine-, CL316,243-, or forskolin-induced increases in lipolysis, UCP1 mRNA, and O2 consumption are all reduced due to impaired cAMP generation. These hypothyroid-like abnormalities are completely reversed by a single injection of T3 14 hours earlier. Recent studies suggest that UCP1 is primarily dependent on thyroid hormone receptor β (TRβ) while the normal sympathetic response of brown adipocytes requires TRα. Intracellularly generated T3 may be required to saturate the TRα, which has an approximately fourfold lower T3-binding affinity than does TRβ. Thus, D2 is an essential component in the thyroid-sympathetic synergism required for thermal homeostasis in small mammals.
Authors
Lucia A. de Jesus, Suzy D. Carvalho, Mirian O. Ribeiro, Mark Schneider, Sung-Woo Kim, John W. Harney, P. Reed Larsen, Antonio C. Bianco
Total citations by year
Citation information
Citations to this article (245)
| Title and authors | Publication | Year |
|---|---|---|
|
Thyroid Hormones and Metabolism Regulation: Which Role on Brown Adipose Tissue and Browning Process?
Sabatino L, Vassalle C |
Biomolecules | 2025 |
|
Lipodystrophy in methylmalonic acidemia associated with elevated FGF21 and abnormal methylmalonylation
Irini Manoli, Justin Sysol, PamelaSara Head, Madeline W. Epping, Oksana Gavrilova, Melissa Crocker, Jennifer Sloan, Stefanos A. Koutsoukos, Cindy X Wang, Yiouli Ktena, Sophia Mendelson, Alexandra Pass, Patricia M. Zerfas, Victoria Hoffmann, Hilary Vernon, Laura Fletcher, James Reynolds, Maria Tsokos, Constantine A. Stratakis, Stephan Voss, Kong Chen, Rebecca Brown, Ada Hamosh, Gerard Berry, Xiaoyuan (Shawn) Chen, Jack Yanovski, Charles P. Venditti |
JCI Insight | 2024 |
|
Low thyroxine serves as an upstream regulator of ecophysiological adaptations in Ansell’s mole-rats
Gerhardt P, Begall S, Frädrich C, Renko K, Heinrich A, Köhrle J, Henning Y |
Frontiers in Endocrinology | 2024 |
|
Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets
Fleishman JS, Kumar S |
Signal Transduction and Targeted Therapy | 2024 |
|
Genetic Background Strongly Influences the Impact of Carrying the Thr92Ala-DIO2 Polymorphism in the Male Mouse
Gabriel de Almeida G, Bolin AP, Batistuzzo A, Fonseca TL, Ribeiro MO, Bianco AC |
Endocrinology | 2024 |
|
Molecular Regulation of Thermogenic Mechanisms in Beige Adipocytes
Yang S, Liu Y, Wu X, Zhu R, Sun Y, Zou S, Zhang D, Yang X |
International journal of molecular sciences | 2024 |
|
MicroRNA-21 modulates brown adipose tissue adipogenesis and thermogenesis in a mouse model of polycystic ovary syndrome
Rezq S, Huffman AM, Basnet J, Alsemeh AE, do Carmo JM, Yanes Cardozo LL, Romero DG |
Biology of sex differences | 2024 |
|
Doublecortin-like knockdown in mice attenuates obesity by stimulating energy expenditure in adipose tissue.
Modder M, Coomans CP, Saaltink DJ, Tersteeg MMH, Hoogduin J, Scholten L, Pronk ACM, Lalai RA, Boelen A, Kalsbeek A, Rensen PCN, Vreugdenhil E, Kooijman S |
Scientific reports | 2024 |
|
Sympathetic innervation of interscapular brown adipose tissue is not a predominant mediator of OT-elicited reductions of body weight gain and adiposity in male diet-induced obese rats.
Edwards MM, Nguyen HK, Dodson AD, Herbertson AJ, Honeycutt MK, Slattery JD, Rambousek JR, Tsui E, Wolden-Hanson T, Wietecha TA, Graham JL, Tapia GP, Sikkema CL, O'Brien KD, Mundinger TO, Peskind ER, Ryu V, Havel PJ, Khan AM, Taborsky GJ Jr, Blevins JE |
bioRxiv : the preprint server for biology | 2024 |
|
Impaired energy expenditure following exposure to either DDT or DDE in mice may be mediated by DNA methylation changes in brown adipose
Jugan JA, Jackson KB, Elmore SE, La Merrill MA |
Environmental Epigenetics | 2024 |
|
Senescent cell depletion alleviates obesity-related metabolic and cardiac disorders
de Oliveira Silva T, Lunardon G, Lino CA, de Almeida Silva A, Zhang S, Irigoyen MC, Lu YW, Mably JD, Barreto-Chaves ML, Wang DZ, Diniz GP |
Molecular Metabolism | 2024 |
|
Sympathetic innervation of interscapular brown adipose tissue is not a predominant mediator of Oxytocin (OT)-elicited reductions of body weight gain and adiposity in male diet-induced obese rats
Edwards MM, Nguyen HK, Dodson AD, Herbertson AJ, Honeycutt MK, Slattery JD, Rambousek JR, Tsui E, Wolden-Hanson T, Wietecha TA, Graham JL, Tapia GP, Sikkema CL, O\u2019Brien KD, Mundinger TO, Peskind ER, Ryu V, Havel PJ, Khan AM, Taborsky GJ Jr, Blevins JE |
Frontiers in drug delivery | 2024 |
|
Fructose consumption induces molecular adaptations involving thyroid function and thyroid-related genes in brown adipose tissue in rats
Neto JG, Romão JS, Pazos-Moura CC, Oliveira KJ |
Brazilian Journal of Medical and Biological Research | 2023 |
|
Thyroid Hormone Metabolism: A Historical Perspective
Galton VA, Hernandez A |
Thyroid : official journal of the American Thyroid Association | 2023 |
|
Acute effect of propranolol on resting energy expenditure in hyperthyroid patients
Senn JR, Löliger RC, Fischer JG, Bur F, Maushart CI, Betz MJ |
Frontiers in Endocrinology | 2023 |
|
Comparative analysis of thyroid hormone systems in rodents with subterranean lifestyle
Gerhardt P, Begall S, Frädrich C, Renko K, Hildebrandt TB, Holtze S, Heinrich A, Sahm A, Meci X, Köhrle J, Rijntjes E, Henning Y |
Scientific Reports | 2023 |
|
Time of day determines postexercise metabolism in mouse adipose tissue.
Pendergrast LA, Lundell LS, Ehrlich AM, Ashcroft SP, Schönke M, Basse AL, Krook A, Treebak JT, Dollet L, Zierath JR |
Proceedings of the National Academy of Sciences | 2023 |
|
Loss of SQSTM1/p62 Induces Obesity and Exacerbates Alcohol-Induced Liver Injury in Aged Mice
Qian H, Chao X, Wang S, Li Y, Jiang X, Sun Z, Rülicke T, Zatloukal K, Ni HM, Ding WX |
Cellular and Molecular Gastroenterology and Hepatology | 2023 |
|
Thermogenic Capacity of Human Supraclavicular Brown Fat and Cold-Stimulated Brain Glucose Metabolism.
U-Din M, Rebelos E, Saari T, Niemi T, Kuellmer K, Eskola O, Fromme T, Rajander J, Taittonen M, Klingenspor M, Nuutila P, Nummenmaa L, Virtanen KA |
Metabolites | 2023 |
|
The Physiological Functions and Polymorphisms of Type II Deiodinase
Deng Y, Han Y, Gao S, Dong W, Yu Y |
Endocrinology and Metabolism | 2023 |
|
Dose- and Time-Dependent Effects of Radiofrequency Electromagnetic Field on Adipose Tissue: Implications of Thermoregulation and Mitochondrial Signaling
Maalouf J, Pelletier A, Corona A, Gay-Quéheillard J, Bach V, de Seze R, Selmaoui B |
International journal of molecular sciences | 2023 |
|
Parathyroid Hormone Related Protein (PTHrP)-Associated Molecular Signatures in Tissue Differentiation and Non-Tumoral Diseases.
Librizzi M, Naselli F, Abruscato G, Luparello C, Caradonna F |
Biology | 2023 |
|
Research Progress of Takeda G Protein-Coupled Receptor 5 in Metabolic Syndrome
Gou X, Qin L, Wu D, Xie J, Lu Y, Zhang Q, He Y |
Molecules (Basel, Switzerland) | 2023 |
|
Localized T3 production modifies the transcriptome and promotes the hepatocyte-like lineage in iPSC-derived hepatic organoids
Jorge Hidalgo-Álvarez, Federico Salas-Lucia, Diana Vera Cruz, Tatiana Fonseca, Antonio C. Bianco |
JCI Insight | 2023 |
|
Brown adipose tissue but not tibia exhibits a dramatic response to acute reduction in environmental temperature in growing male mice
Wong CP, Iwaniec UT, Turner RT |
Bone Reports | 2023 |
|
Understanding the Roles of Selenium on Thyroid Hormone-Induced Thermogenesis in Adipose Tissue.
Ruswandi YAR, Lesmana R, Rosdianto AM, Gunadi JW, Goenawan H, Zulhendri F |
Biological Trace Element Research | 2023 |
|
Hypoxic and hypercapnic burrow conditions lead to downregulation of free triiodothyronine and hematocrit in Ansell's mole-rats (Fukomys anselli).
Henning Y, Adam K, Gerhardt P, Begall S |
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology | 2023 |
|
Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2
A Cicatiello, S Sagliocchi, A Nappi, E Cicco, C Miro, M Murolo, M Stornaiuolo, M Dentice |
Cell Reports | 2022 |
|
ApoA1 Deficiency Reshapes the Phenotypic and Molecular Characteristics of Bone Marrow Adipocytes in Mice
A Kastrenopoulou, K Kypreos, N Papachristou, S Georgopoulos, I Mastora, I Papadimitriou-Olivgeri, A Spentzopoulou, D Nikitovic, V Kontogeorgakos, H Blair, D Papachristou |
International journal of molecular sciences | 2022 |
|
Inactivation of Type 3 Deiodinase Results in Life-long Changes in the Brown Adipose Tissue Transcriptome in the Male Mouse
T Fonseca, S Russo, C Luongo, D Salvatore, A Bianco |
Endocrinology | 2022 |
|
Interplay between Fatty Acid Binding Protein 4, Fetuin-A, Retinol Binding Protein 4 and Thyroid Function in Metabolic Dysregulation
D Dadej, E Szczepanek-Parulska, M Ruchała |
Metabolites | 2022 |
|
Liraglutide Activates Type 2 Deiodinase and Enhances β3-Adrenergic-Induced Thermogenesis in Mouse Adipose Tissue
Oliveira FC, Bauer EJ, Ribeiro CM, Pereira SA, Beserra BT, Wajner SM, Maia AL, Neves FA, Coelho MS, Amato AA |
Frontiers in Endocrinology | 2022 |
|
Resting Energy Expenditure and Cold-induced Thermogenesis in Patients With Overt Hyperthyroidism.
Maushart CI, Senn JR, Loeliger RC, Siegenthaler J, Bur F, Fischer JGW, Betz MJ |
The Journal of clinical endocrinology and metabolism | 2022 |
|
The Heartwarming Effect of Brown Adipose Tissue
Pinckard KM, Stanford KI |
Molecular pharmacology | 2022 |
|
Differential temperature effects on photoperiodism in female voles: A possible explanation for declines in vole populations
van Rosmalen L, Riedstra B, Beemster N, Dijkstra C, Hut RA |
Molecular ecology | 2022 |
|
Adtrp regulates thermogenic activity of adipose tissue via mediating the secretion of S100b.
Li P, Song R, Du Y, Liu H, Li X |
Cellular and molecular life sciences : CMLS | 2022 |
|
RNAseq Analysis of Brown Adipose Tissue and Thyroid of Newborn Lambs Subjected to Short-Term Cold Exposure Reveals Signs of Early Whitening of Adipose Tissue.
Graña-Baumgartner A, Dukkipati VSR, Kenyon PR, Blair HT, López-Villalobos N, Gedye K, Biggs PJ |
Metabolites | 2022 |
|
Tracking footprints of artificial and natural selection signatures in breeding and non-breeding cats.
Zhang X, Jamwal K, Distl O |
Scientific Reports | 2022 |
|
Brown adipocytes local response to thyroid hormone is required for adaptive thermogenesis in adult male mice.
Zekri Y, Guyot R, Suñer IG, Canaple L, Stein AG, Petit JV, Aubert D, Richard S, Flamant F, Gauthier K |
eLife | 2022 |
|
miR-130b/301b Is a Negative Regulator of Beige Adipogenesis and Energy Metabolism In Vitro and In Vivo
Luo W, Kim Y, Jensen ME, Herlea-Pana O, Wang W, Rudolph MC, Friedman JE, Chernausek SD, Jiang S |
Diabetes | 2022 |
|
Selenium status and type 2 diabetes risk
Huang YC, Combs GF Jr, Wu TL, Zeng H, Cheng WH |
Archives of Biochemistry and Biophysics | 2022 |
|
SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice.
Yoshizawa T, Sato Y, Sobuz SU, Mizumoto T, Tsuyama T, Karim MF, Miyata K, Tasaki M, Yamazaki M, Kariba Y, Araki N, Araki E, Kajimura S, Oike Y, Braun T, Bober E, Auwerx J, Yamagata K |
Nature Communications | 2022 |
|
Roles of leptin on energy balance and thermoregulation in Eothenomys miletus.
Chen H, Zhang H, Jia T, Wang Z, Zhu W |
Frontiers in physiology | 2022 |
|
Brown Adipose Tissue—A Translational Perspective
Carpentier AC, Blondin DP, Haman F, Richard D |
Endocrine reviews | 2022 |
|
Selenium and selenoproteins in thermogenic adipocytes
Shimada BK, Watanabe LM, Swanson S, Toh P, Seale LA |
Archives of Biochemistry and Biophysics | 2022 |
|
MicroRNA-33 Inhibits Adaptive Thermogenesis and Adipose Tissue Beiging
MS Afonso, N Verma, C van Solingen, Y Cyr, M Sharma, L Perie, EM Corr, M Schlegel, LC Shanley, D Peled, JY Yoo, AM Schmidt, E Mueller, KJ Moore |
Arteriosclerosis, thrombosis, and vascular biology | 2021 |
|
Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential
BB Brandão, A Poojari, A Rabiee |
International journal of molecular sciences | 2021 |
|
Deiodinases and the Metabolic Code for Thyroid Hormone Action
SC Russo, F Salas-Lucia, AC Bianco |
Endocrinology | 2021 |
|
miRNA-22 deletion limits white adipose expansion and activates brown fat to attenuate high-fat diet-induced fat mass accumulation
VM Lima, J Liu, BB Brandão, CA Lino, CS Silva, MA Ribeiro, TE Oliveira, CC Real, D de Paula Faria, C Cederquist, ZP Huang, X Hu, ML Barreto-Chaves, JC Ferreira, WT Festuccia, MA Mori, CR Kahn, DZ Wang, GP Diniz |
Metabolism | 2021 |
|
Signaling Pathways Regulating Thermogenesis
C Tabuchi, HS Sul |
Frontiers in Endocrinology | 2021 |
|
Thyroid hormones in the regulation of brown adipose tissue thermogenesis
SC Sentis, R Oelkrug, J Mittag |
Endocrine Connections | 2021 |
|
Adaptive Thermogenesis in a Mouse Model Lacking Selenoprotein Biosynthesis in Brown Adipocytes
LA Seale, AN Ogawa-Wong, LM Watanabe, VS Khadka, M Menor, DJ Torres, BA Carlson, DL Hatfield, MJ Berry |
International journal of molecular sciences | 2021 |
|
Brown Adipose Tissue Heterogeneity, Energy Metabolism, and Beyond
AB Shinde, A Song, QA Wang |
Frontiers in Endocrinology | 2021 |
|
Diet-regulated production of PDGFcc by macrophages controls energy storage
N Cox, L Crozet, IR Holtman, PL Loyher, T Lazarov, JB White, E Mass, ER Stanley, O Elemento, CK Glass, F Geissmann |
Science | 2021 |
|
Insights into the Cellular and Molecular Mechanisms That Govern the Fracture-Healing Process: A Narrative Review
DJ Papachristou, S Georgopoulos, PV Giannoudis, E Panagiotopoulos |
Journal of Clinical Medicine | 2021 |
|
Regulation of thyroid hormones and branchial iodothyronine deiodinases during freshwater acclimation in tilapia
LA Seale, CL Gilman, AM Zavacki, PR Larsen, M Inokuchi, JP Breves, AP Seale |
Molecular and Cellular Endocrinology | 2021 |
|
Thyroid Hormone Deiodinases: Dynamic Switches in Developmental Transitions
A Hernandez, ME Martinez, L Ng, D Forrest |
Endocrinology | 2021 |
|
Central vs. Peripheral Action of Thyroid Hormone in Adaptive Thermogenesis: A Burning Topic
Y Zekri, F Flamant, K Gauthier |
Cells | 2021 |
|
Obesity and Thyroid Axis
K Walczak, L Sieminska |
International journal of environmental research and public health | 2021 |
|
Free Thyroxine Levels are Associated with Cold Induced Thermogenesis in Healthy Euthyroid Individuals
CI Maushart, JR Senn, RC Loeliger, ME Kraenzlin, J Müller, AS Becker, M Balaz, C Wolfrum, IA Burger, MJ Betz |
Frontiers in Endocrinology | 2021 |
|
Deiodinases and the Three Types of Thyroid Hormone Deiodination Reactions
L Sabatino, C Vassalle, CD Seppia, G Iervasi |
Endocrinology and Metabolism | 2021 |
|
Gene Expression Analysis of Environmental Temperature and High-Fat Diet-Induced Changes in Mouse Supraclavicular Brown Adipose Tissue
Y Shi, H Zhai, S John, YT Shen, Y Ran, G Hoang, MH Chen |
Cells | 2021 |
|
D-Mannitol Induces a Brown Fat-like Phenotype via a β3-Adrenergic Receptor-Dependent Mechanism
HJ Jeon, DK Choi, JH Choi, S Lee, H Lee, JH Yu, SH Min |
Cells | 2021 |
|
Sex-Specific Metabolic Impairments in a Mouse Model of Disrupted Selenium Utilization
PM Kremer, DJ Torres, AC Hashimoto, MJ Berry |
Frontiers in Nutrition | 2021 |
|
Brown Adipose Tissue: New Challenges for Prevention of Childhood Obesity. A Narrative Review
E Verduci, V Calcaterra, ED Profio, G Fiore, F Rey, VC Magenes, CF Todisco, S Carelli, GV Zuccotti |
Nutrients | 2021 |
|
Unraveling the Developmental Roadmap toward Human Brown Adipose Tissue
S Carobbio, AC Guenantin, M Bahri, S Rodriguez-Fdez, F Honig, I Kamzolas, I Samuelson, K Long, S Awad, D Lukovic, S Erceg, A Bassett, S Mendjan, L Vallier, BS Rosen, D Chiarugi, A Vidal-Puig |
Stem Cell Reports | 2021 |
|
Liver Proteome Profile of Growth Restricted and Appropriately Grown Newborn Wistar Rats Associated With Maternal Undernutrition
PM Sarli, A Manousopoulou, E Efthymiou, A Zouridis, A Potiris, P Pervanidou, K Panoulis, N Vlahos, E Deligeoroglou, SD Garbis, M Eleftheriades |
Frontiers in Endocrinology | 2021 |
|
Thermoregulation in hibernating mammals: The role of the “thyroid hormones system”
C Frare, CT Williams, KL Drew |
Molecular and Cellular Endocrinology | 2021 |
|
Metabolic Derangement in Pediatric Patient with Obesity: The Role of Ketogenic Diet as Therapeutic Tool
V Calcaterra, E Verduci, MC Pascuzzi, VC Magenes, G Fiore, ED Profio, E Tenuta, A Bosetti, CF Todisco, E DAuria, G Zuccotti |
Nutrients | 2021 |
|
Metabolic effects of brown fat in transitioning from hyperthyroidism to euthyroidism
L Sun, HJ Goh, S Verma, P Govindharajulu, SA Sadananthan, N Michael, Y Jadegoud, CJ Henry, SS Velan, PS Yeo, Y Lee, BS Lim, H Liew, CK Chew, TP Quek, SA Shakoor, WH Hoi, SP Chan, DE Chew, R Dalan, MK Leow |
European Journal of Endocrinology | 2021 |
|
Endocrine Disrupting Chemicals: Friend or Foe to Brown and Beige Adipose Tissue?
Francis CE, Allee L, Nguyen H, Grindstaff RD, Miller CN, Rayalam S |
Toxicology | 2021 |
|
Exercise‐induced α‐ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1‐dependent adrenal activation
Y Yuan, P Xu, Q Jiang, X Cai, T Wang, W Peng, J Sun, C Zhu, C Zhang, D Yue, Z He, J Yang, Y Zeng, M Du, F Zhang, L Ibrahimi, S Schaul, Y Jiang, J Wang, J Sun, Q Wang, L Liu, S Wang, L Wang, X Zhu, P Gao, , C Yin, F Li, G Xu, Y Zhang, G Shu |
The EMBO Journal | 2020 |
|
Thermogenesis in Adipose Tissue Activated by Thyroid Hormone
WW Yau, PM Yen |
International journal of molecular sciences | 2020 |
|
A Feedforward Loop within the Thyroid-Brown Fat Axis Facilitates Thermoregulation
L Sun, HJ Goh, P Govindharajulu, L Sun, CJ Henry, MK Leow |
Scientific Reports | 2020 |
|
Control of Adipocyte Thermogenesis and Lipogenesis through β3-Adrenergic and Thyroid Hormone Signal Integration
A Guilherme, B Yenilmez, AH Bedard, F Henriques, D Liu, A Lee, L Goldstein, M Kelly, SM Nicoloro, M Chen, L Weinstein, S Collins, MP Czech |
Cell Reports | 2020 |
|
Supplementation with a prebiotic (polydextrose) in obese mouse pregnancy improves maternal glucose homeostasis and protects against offspring obesity
X Maragkoudaki, M Naylor, G Papacleovoulou, E Stolarczyk, D Rees, JM Pombo, S Abu-Hayyeh, A Czajka, JK Howard, AN Malik, C Williamson, L Poston, PD Taylor |
International Journal of Obesity | 2020 |
|
Moderate SIRT1 overexpression protects against brown adipose tissue inflammation
C Escalona-Garrido, P Vázquez, P Mera, S Zagmutt, E García-Casarrubios, A Montero-Pedrazuela, F Rey-Stolle, A Guadaño-Ferraz, FJ Rupérez, D Serra, L Herrero, MJ Obregon, ÁM Valverde |
Molecular Metabolism | 2020 |
|
Activated brown adipose tissue and its relationship to adiposity and metabolic markers: an exploratory study
M Soundarrajan, J Deng, M Kwasny, NC Rubert, PC Nelson, DA El-Seoud, L Landsberg, LM Neff |
Adipocyte | 2020 |
|
Supplementary prenatal copper increases plasma triiodothyronine and brown adipose tissue uncoupling protein-1 gene expression but depresses thermogenesis in newborn lambs
SB Smith, CR Sweatt, GE Carstens |
Asian-Australasian Journal of Animal Sciences | 2020 |
|
Pinealectomy increases thermogenesis and decreases lipogenesis
M Kim, S Lee, J Jung, Y Kim, K Moon, J Seo, T Ha, E Ha |
Molecular medicine reports | 2020 |
|
Egr1 loss-of-function promotes beige adipocyte differentiation and activation specifically in inguinal subcutaneous white adipose tissue
M Bléher, B Meshko, I Cacciapuoti, R Gergondey, Y Kovacs, D Duprez, A LHonoré, E Havis |
Scientific Reports | 2020 |
|
Investigation of the Relationship between MR-Based Supraclavicular Fat Fraction and Thyroid Hormones
D Junker, J Syväri, D Weidlich, C Holzapfel, T Drabsch, B Waschulzik, EJ Rummeny, H Hauner, DC Karampinos |
Obesity facts | 2020 |
|
Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism
S Pearson, A Loft, P Rahbhandari, J Simcox, S Lee, P Tontonoz, S Mandrup, CJ Villanueva |
Genes & development | 2019 |
|
Paradigms of Dynamic Control of Thyroid Hormone Signaling
AC Bianco, A Dumitrescu, B Gereben, MO Ribeiro, TL Fonseca, GW Fernandes, BM Bocco |
Endocrine reviews | 2019 |
|
Fibroblast Growth Factor 21 and the Adaptive Response to Nutritional Challenges
Ú Martínez-Garza, D Torres-Oteros, A Yarritu-Gallego, PF Marrero, D Haro, J Relat |
International journal of molecular sciences | 2019 |
|
Effects of Short-Term Fasting and Different Overfeeding Diets on Thyroid Hormones in Healthy Humans
A Basolo, B Begaye, T Hollstein, KL Vinales, M Walter, F Santini, J Krakoff, P Piaggi |
Thyroid | 2019 |
|
A Global Loss of Dio2 Leads to Unexpected Changes in Function and Fiber Types of Slow Skeletal Muscle in Male Mice
C Carmody, AN Ogawa-Wong, C Martin, C Luongo, M Zuidwijk, B Sager, T Petersen, AR Guetter, R Janssen, EY Wu, S Bogaards, NM Neumann, K Hau, A Marsili, A Boelen, JE Silva, M Dentice, D Salvatore, AJ Wagers, PR Larsen, WS Simonides, AM Zavacki |
Endocrinology | 2019 |
|
Resolution of Hypothyroidism Restores Cold Induced Thermogenesis in Humans
CI Maushart, R Loeliger, G Gashi, M Christ-Crain, MJ Betz |
Thyroid | 2019 |
|
The hepatokine Tsukushi gates energy expenditure via brown fat sympathetic innervation
Q Wang, VP Sharma, H Shen, Y Xiao, Q Zhu, X Xiong, L Guo, L Jiang, K Ohta, S Li, H Shi, L Rui, JD Lin |
2019 | |
|
Compensation for cold-induced thermogenesis during weight loss maintenance and regain
DM Presby, MR Jackman, MC Rudolph, VD Sherk, RM Foright, JA Houck, GC Johnson, DJ Orlicky, EL Melanson, JA Higgins, PS MacLean |
American journal of physiology. Endocrinology and metabolism | 2019 |
|
Carcinoembryonic Cell Adhesion-Related Molecule 2 Regulates Insulin Secretion and Energy Balance
E Salaheldeen, A Jaume, SM Najjar |
International journal of molecular sciences | 2019 |
|
Agrp-Specific Ablation of Scly Protects against Diet-Induced Obesity and Leptin Resistance
DJ Torres, MW Pitts, AC Hashimoto, MJ Berry |
Nutrients | 2019 |
|
The Impact of the Adipose Organ Plasticity on Inflammation and Cancer Progression
Corrêa, Heyn, Magalhaes |
Cells | 2019 |
|
The Role of Brown Adipose Tissue in Cardiovascular Disease Protection: Current Evidence and Future Directions
R Pereira, S McFarlane |
2019 | |
|
The Beige Adipocyte as a Therapy for Metabolic Diseases
F Lizcano |
International journal of molecular sciences | 2019 |
|
Brown Adipose Tissue Response to Cold Stimulation Is Reduced in Girls With Autoimmune Hypothyroidism
JM Law, DE Morris, V Astle, E Finn, JJ Muros, LJ Robinson, T Randell, L Denvir, ME Symonds, H Budge |
Journal of the Endocrine Society | 2019 |
|
Tolerance to Selenoprotein Loss Differs between Human and Mouse
D Santesmasses, M Mariotti, VN Gladyshev, N Saitou |
Molecular Biology and Evolution | 2019 |
|
Thyroid Hormone Nuclear Receptor: Methods and Protocols
M Plateroti, J Samarut |
2018 | |
|
Hypothalamic redox balance and leptin signaling - Emerging role of selenoproteins
T Gong, DJ Torres, MJ Berry, MW Pitts |
Free radical biology & medicine | 2018 |
|
Changes in Body Compositions and Basal Metabolic Rates during Treatment of Graves’ Disease
MJ Kim, SW Cho, S Choi, DL Ju, DJ Park, YJ Park |
International Journal of Endocrinology | 2018 |
|
Similarities and Differences in the Peripheral Actions of Thyroid Hormones and Their Metabolites
RA Louzada, DP Carvalho |
Frontiers in Endocrinology | 2018 |
|
TRH Neurons and Thyroid Hormone Coordinate the Hypothalamic Response to Cold
Z Zhang, A Boelen, A Kalsbeek, E Fliers |
European Thyroid Journal | 2018 |
|
Natriuretic peptides promote glucose uptake in a cGMP-dependent manner in human adipocytes
M Coué, V Barquissau, P Morigny, K Louche, C Lefort, A Mairal, C Carpéné, N Viguerie, P Arner, D Langin, M Rydén, C Moro |
Scientific Reports | 2018 |
|
Evaluation and optimization of differentiation conditions for human primary brown adipocytes
XY Wang, LH You, XW Cui, Y Li, X Wang, PF Xu, LJ Zhu, J Wen, LX Pang, XR Guo, CB Ji |
Scientific Reports | 2018 |
|
Central regulation of energy metabolism by estrogens
Y Xu, M López |
Molecular Metabolism | 2018 |
|
Do TSH, FT3, and FT4 Impact BAT Visualization of Clinical FDG-PET/CT Images?
R Nishii, S Nagamachi, Y Mizutani, T Terada, S Kiyohara, H Wakamatsu, S Fujita, T Higashi, K Yoshinaga, T Saga, T Hirai |
Contrast Media & Molecular Imaging | 2018 |
|
Metabolic Effects of the Intracellular Regulation of Thyroid Hormone: Old Players, New Concepts
AG Cicatiello, DD Girolamo, M Dentice |
Frontiers in Endocrinology | 2018 |
|
Low temperature exposure induces browning of bone marrow stem cell derived adipocytes in vitro
K Velickovic, HA Leija, I Bloor, J Law, H Sacks, M Symonds, V Sottile |
Scientific Reports | 2018 |
|
Adipocyte DIO2 Expression Increases in Human Obesity but Is Not Related to Systemic Insulin Sensitivity
D Bradley, J Liu, A Blaszczak, V Wright, A Jalilvand, B Needleman, S Noria, D Renton, W Hsueh |
Journal of Diabetes Research | 2018 |
|
FGF21 decreases body weight without reducing food intake or bone mineral density in high-fat fed obese rhesus macaque monkeys
B Andersen, EM Straarup, KM Heppner, DL Takahashi, V Raffaele, GA Dissen, K Lewandowski, TB Bödvarsdottir, K Raun, KL Grove, P Kievit |
International Journal of Obesity | 2018 |
|
NT-PGC-1α deficiency decreases mitochondrial FA oxidation in brown adipose tissue and alters substrate utilization in vivo
J Kim, MS Park, K Ha, C Park, J Lee, RL Mynatt, JS Chang |
Journal of lipid research | 2018 |
|
Effect of Iodothyronines on Thermogenesis: Focus on Brown Adipose Tissue
F Cioffi, A Gentile, E Silvestri, F Goglia, A Lombardi |
Frontiers in Endocrinology | 2018 |
|
Promotion of lipid storage rather than of thermogenic competence by fetal versus newborn calf serum in primary cultures of brown adipocytes
JM de Jong, B Cannon, J Nedergaard |
Adipocyte | 2018 |
|
Lipoprotein Lipase Expression in Hypothalamus Is Involved in the Central Regulation of Thermogenesis and the Response to Cold Exposure
E Laperrousaz, RG Denis, N Kassis, C Contreras, M López, S Luquet, C Cruciani-Guglielmacci, C Magnan |
Frontiers in Endocrinology | 2018 |
|
Deficiency of type 2 iodothyronine deiodinase reduces necroptosis activity and oxidative stress responses in retinas of Leber congenital amaurosis model mice
F Yang, H Ma, MR Butler, |
The FASEB Journal | 2018 |
|
Deficiency in interleukin-18 promotes differentiation of brown adipose tissue resulting in fat accumulation despite dyslipidemia
K Yamanishi, S Maeda, S Kuwahara-Otani, T Hashimoto, K Ikubo, K Mukai, K Nakasho, N Gamachi, Y El-Darawish, W Li, D Okuzaki, Y Watanabe, H Yamanishi, H Okamura, H Matsunaga |
Journal of Translational Medicine | 2018 |
|
Thyroid hormone (T 3 ) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy
WW Yau, BK Singh, R Lesmana, J Zhou, RA Sinha, KA Wong, Y Wu, BH Bay, S Sugii, L Sun, PM Yen |
Autophagy | 2018 |
|
Switching harmful visceral fat to beneficial energy combustion improves metabolic dysfunctions
Xiaoyan Yang, Wenhai Sui, Meng Zhang, Mei Dong, Sharon Lim, Takahiro Seki, Ziheng Guo, Carina Fischer, Huixia Lu, Cheng Zhang, Jianmin Yang, Meng Zhang, Yangang Wang, Caixia Cao, Yanyan Gao, Xingguo Zhao, Meili Sun, Yuping Sun, Rujie Zhuang, Nilesh Samani, Yun Zhang, Yihai Cao |
JCI Insight | 2017 |
|
Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function
G Yu, A Tzouvelekis, R Wang, JD Herazo-Maya, GH Ibarra, A Srivastava, JP de Castro, G DeIuliis, F Ahangari, T Woolard, N Aurelien, RA Drigo, Y Gan, M Graham, X Liu, RJ Homer, TS Scanlan, P Mannam, PJ Lee, EL Herzog, AC Bianco, N Kaminski |
Nature Medicine | 2017 |
|
A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes
L Shu, RL Hoo, X Wu, Y Pan, IP Lee, LY Cheong, SR Bornstein, X Rong, J Guo, A Xu |
Nature Communications | 2017 |
|
White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function
YW Chung, F Ahmad, Y Tang, SC Hockman, HJ Kee, K Berger, E Guirguis, YH Choi, DM Schimel, AM Aponte, S Park, E Degerman, VC Manganiello |
Scientific Reports | 2017 |
|
Remodeling of rat stromal-vascular cells to brite/beige adipocytes by prolyl-hydroxyproline
JA MINAGUCHI, S OGATA, N TAKAHASHI, T HIROSE, H UEDA, K TAKEHANA |
Journal of Veterinary Medical Science | 2017 |
|
Age-dependent insulin resistance in male mice with null deletion of the carcinoembryonic antigen-related cell adhesion molecule 2 gene
SS Ghanem, HT Muturi, AM DeAngelis, J Hu, RN Kulkarni, G Heinrich, SM Najjar |
Diabetologia | 2017 |
|
Egr1 deficiency induces browning of inguinal subcutaneous white adipose tissue in mice
C Milet, M Bléher, K Allbright, M Orgeur, F Coulpier, D Duprez, E Havis |
Scientific Reports | 2017 |
|
Brown adipose tissue transplantation ameliorates polycystic ovary syndrome
X Yuan, T Hu, H Zhao, Y Huang, R Ye, J Lin, C Zhang, H Zhang, G Wei, H Zhou, M Dong, J Zhao, H Wang, Q Liu, HJ Lee, W Jin, ZJ Chen |
Proceedings of the National Academy of Sciences | 2016 |
|
Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity
A Caron, SM Labbé, D Lanfray, PG Blanchard, R Villot, C Roy, DM Sabatini, D Richard, M Laplante |
Molecular Metabolism | 2016 |
|
Uncoupling Proteins and the Molecular Mechanisms of Thyroid Thermogenesis
A Solmonson, EM Mills |
Endocrinology | 2016 |
|
Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice
J Weiner, M Kranz, N Klöting, A Kunath, K Steinhoff, E Rijntjes, J Köhrle, V Zeisig, M Hankir, C Gebhardt, W Deuther-Conrad, JT Heiker, S Kralisch, M Stumvoll, M Blüher, O Sabri, S Hesse, P Brust, A Tönjes, K Krause |
Scientific Reports | 2016 |
|
The role of innate immunity in the regulation of brown and beige adipogenesis
VI Alexaki, T Chavakis |
Reviews in Endocrine and Metabolic Disorders | 2016 |
|
Targeting iodothyronine deiodinases locally in the retina is a therapeutic strategy for retinal degeneration
F Yang, H Ma, J Belcher, MR Butler, TM Redmond, SL Boye, WW Hauswirth, XQ Ding |
The FASEB Journal | 2016 |
|
Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue
CM Tran, S Mukherjee, L Ye, DW Frederick, M Kissig, JG Davis, DW Lamming, P Seale, JA Baur |
Diabetes | 2016 |
|
Altered Microbiota Contributes to Reduced Diet-Induced Obesity upon Cold Exposure
M Ziętak, P Kovatcheva-Datchary, LH Markiewicz, M Ståhlman, LP Kozak, F Bäckhed |
Cell Metabolism | 2016 |
|
AHNAK deficiency promotes browning and lipolysis in mice via increased responsiveness to β-adrenergic signalling
JH Shin, SH Lee, YN Kim, IY Kim, YJ Kim, DS Kyeong, HJ Lim, SY Cho, J Choi, YJ Wi, JH Choi, YS Yoon, YS Bae, JK Seong |
Scientific Reports | 2016 |
|
Selenium and Metabolic Disorders: An Emphasis on Type 2 Diabetes Risk
AN Ogawa-Wong, MJ Berry, LA Seale |
Nutrients | 2016 |
|
Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice
BM Bocco, GW Fernandes, FB Lorena, RM Cysneiros, MA Christoffolete, SS Grecco, CL Lancellotti, P Romoff, JH Lago, AC Bianco, MO Ribeiro |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] | 2016 |
|
Thyroid Hormone Activates Brown Adipose Tissue and Increases Non-Shivering Thermogenesis - A Cohort Study in a Group of Thyroid Carcinoma Patients
EP Broeders, GH Vijgen, B Havekes, ND Bouvy, FM Mottaghy, M Kars, NC Schaper, P Schrauwen, B Brans, WD van Lichtenbelt, J Ye |
PloS one | 2016 |
|
Endocannabinoid regulation in white and brown adipose tissue following thermogenic activation
LM Krott, F Piscitelli, M Heine, S Borrino, L Scheja, C Silvestri, J Heeren, VD Marzo |
Journal of lipid research | 2016 |
|
The effects on weight loss and gene expression in adipose and hepatic tissues of very-low carbohydrate and low-fat isoenergetic diets in diet-induced obese mice
T Yamazaki, S Okawa, M Takahashi |
Nutrition & Metabolism | 2016 |
|
Attenuation of diet-induced obesity and induction of white fat browning with a chemical inhibitor of histone deacetylases
A Ferrari, E Fiorino, R Longo, S Barilla, N Mitro, G Cermenati, M Giudici, D Caruso, A Mai, U Guerrini, ED Fabiani, M Crestani |
International Journal of Obesity | 2016 |
|
Ldb1 Regulates Energy Homeostasis During Diet-Induced Obesity
C Loyd, Y Liu, T Kim, C Holleman, J Galloway, M Bethea, BN Ediger, Y Tang, TA Swain, DA Stoffers, GC Rowe, M Young, C Steele, KM Habegger, CS Hunter |
Endocrinology | 2016 |
|
Brown adipose tissue: The heat is on the heart
R Thoonen, AG Hindle, M Scherrer-Crosbie |
American journal of physiology. Heart and circulatory physiology | 2016 |
|
Classification of Therapeutic and Experimental Drugs for Brown Adipose Tissue Activation: Potential Treatment Strategies for Diabetes and Obesity
Mukherjee J, Baranwal A, Schade KN |
Current diabetes reviews | 2016 |
|
Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance
AL Poher, J Altirriba, C Veyrat-Durebex, FÃ Rohner-Jeanrenaud |
Frontiers in physiology | 2015 |
|
Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue
G Godlewski, T Jourdan, G Szanda, J Tam, R Cinar, J Harvey-White, J Liu, B Mukhopadhyay, P Pacher, FM Mo, D Osei-Hyiaman, G Kunos |
Scientific Reports | 2015 |
|
Obesity is associated with a decrease in expression but not with the hypermethylation of thermogenesis-related genes in adipose tissues
A Kurylowicz, M Jonas, W Lisik, M Jonas, ZA Wicik, Z Wierzbicki, A Chmura, M Puzianowska-Kuznicka |
Journal of Translational Medicine | 2015 |
|
The Selective Loss of the Type 2 Iodothyronine Deiodinase in Mouse Thyrotrophs Increases Basal TSH but Blunts the Thyrotropin Response to Hypothyroidism
C Luongo, C Martin, K Vella, A Marsili, R Ambrosio, M Dentice, JW Harney, D Salvatore, AM Zavacki, PR Larsen |
Endocrinology | 2015 |
|
Low Temperature-Induced Circulating Triiodothyronine Accelerates Seasonal Testicular Regression
K Ikegami, Y Atsumi, E Yorinaga, H Ono, I Murayama, Y Nakane, W Ota, N Arai, A Tega, M Iigo, VM Darras, K Tsutsui, Y Hayashi, S Yoshida, T Yoshimura |
Endocrinology | 2015 |
|
Absence of Intracellular Ion Channels TPC1 and TPC2 Leads to Mature-Onset Obesity in Male Mice, Due to Impaired Lipid Availability for Thermogenesis in Brown Adipose Tissue
PV Lear, D González-Touceda, BP Couto, P Viaño, V Guymer, E Remzova, R Tunn, A Chalasani, T García-Caballero, IP Hargreaves, PW Tynan, HC Christian, R Nogueiras, J Parrington, C Diéguez |
Endocrinology | 2015 |
|
The brown fat secretome: metabolic functions beyond thermogenesis
GX Wang, XY Zhao, JD Lin |
Trends in Endocrinology & Metabolism | 2015 |
|
De novo lipogenesis in metabolic homeostasis: More friend than foe?
G Solinas, J Borén, AG Dulloo |
Molecular Metabolism | 2015 |
|
Role of Energy Metabolism in the Brown Fat Gene Program
M Nam, MP Cooper |
Frontiers in Endocrinology | 2015 |
|
Non-sympathetic control of brown adipose tissue
R Cereijo, J Villarroya, F Villarroya |
International Journal of Obesity Supplements | 2015 |
|
Effects of Mild Chronic Intermittent Cold Exposure on Rat Organs
X Wang, H Che, W Zhang, J Wang, T Ke, R Cao, S Meng, D Li, O Weiming, J Chen, W Luo |
International journal of biological sciences | 2015 |
|
A New Role for Browning as a Redox and Stress Adaptive Mechanism?
Y Jeanson, A Carrière, L Casteilla |
Frontiers in Endocrinology | 2015 |
|
The brown and brite adipocyte marker Cox7a1 is not required for non-shivering thermogenesis in mice
SF Maurer, T Fromme, LI Grossman, M Hüttemann, M Klingenspor |
Scientific Reports | 2015 |
|
The sympathetic nervous system is controlled by transient receptor potential vanilloid 1 in the regulation of body temperature
KM Alawi, AA Aubdool, L Liang, E Wilde, A Vepa, MP Psefteli, SD Brain, JE Keeble |
The FASEB Journal | 2015 |
|
Bile acids induce uncoupling protein 1-dependent thermogenesis and stimulate energy expenditure at thermoneutrality in mice
M Zietak, LP Kozak |
American journal of physiology. Endocrinology and metabolism | 2015 |
|
Moderate calorie restriction during gestation programs offspring for lower BAT thermogenic capacity driven by thyroid and sympathetic signaling
M Palou, T Priego, M Romero, N Szostaczuk, J Konieczna, C Cabrer, X Remesar, A Palou, C Pico |
International Journal of Obesity | 2014 |
|
Inactivation of the adrenergic receptor 2 disrupts glucose homeostasis in mice
GW Fernandes, CB Ueta, TL Fonseca, CH Gouveia, CL Lancellotti, PC Brum, MA Christoffolete, AC Bianco, MO Ribeiro |
Journal of Endocrinology | 2014 |
|
Thyroid Hormone Regulation of Metabolism
R Mullur, YY Liu, GA Brent |
Physiological reviews | 2014 |
|
The brain and brown fat
C Contreras, F Gonzalez, J Fernø, C Diéguez, K Rahmouni, R Nogueiras, M López |
Annals of Medicine | 2014 |
|
Triiodothyronine regulates distribution of thyroid hormone receptors by activating AMP-activated protein kinase in 3T3-L1 adipocytes and induces uncoupling protein-1 expression
CZ Wang, D Wei, MP Guan, YM Xue |
Molecular and Cellular Biochemistry | 2014 |
|
Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice
MJ Harms, J Ishibashi, W Wang, HW Lim, S Goyama, T Sato, M Kurokawa, KJ Won, P Seale |
Cell Metabolism | 2014 |
|
Brown fat fuel utilization and thermogenesis
KL Townsend, YH Tseng |
Trends in Endocrinology & Metabolism | 2014 |
|
Dietary Fucoxanthin Increases Metabolic Rate and Upregulated mRNA Expressions of the PGC-1alpha Network, Mitochondrial Biogenesis and Fusion Genes in White Adipose Tissues of Mice
MT Wu, HN Chou, C Huang |
Marine drugs | 2014 |
|
Selenoproteins in Nervous System Development and Function
MW Pitts, CN Byrns, AN Ogawa-Wong, P Kremer, MJ Berry |
Biological Trace Element Research | 2014 |
|
Abnormal motor phenotype at adult stages in mice lacking type 2 deiodinase
S Bárez-López, D Bosch-García, D Gómez-Andrés, I Pulido-Valdeolivas, A Montero-Pedrazuela, MJ Obregon, A Guadaño-Ferraz |
PloS one | 2014 |
|
Tissue-Specific Inactivation of Type 2 Deiodinase Reveals Multilevel Control of Fatty Acid Oxidation by Thyroid Hormone in the Mouse
TL Fonseca, JP Werneck-De-Castro, M Castillo, BM Bocco, GW Fernandes, EA McAninch, DL Ignacio, CC Moises, AR Ferreira, B Gereben, AC Bianco |
Diabetes | 2014 |
|
NT-PGC-1 Activation Attenuates High-Fat Diet-Induced Obesity by Enhancing Brown Fat Thermogenesis and Adipose Tissue Oxidative Metabolism
HJ Jun, Y Joshi, Y Patil, RC Noland, JS Chang |
Diabetes | 2014 |
|
Adrenergic pathway activation enhances brown adipose tissue metabolism: A [18F]FDG PET/CT study in mice
MR Mirbolooki, SK Upadhyay, CC Constantinescu, ML Pan, J Mukherjee |
Nuclear Medicine and Biology | 2014 |
|
Regulation of body temperature and brown adipose tissue thermogenesis by bombesin receptor subtype-3
DM Lateef, G Abreu-Vieira, C Xiao, ML Reitman |
American journal of physiology. Endocrinology and metabolism | 2014 |
|
RNA-seq analysis of the rat placentation site reveals maternal obesity-associated changes in placental and offspring thyroid hormone signaling
J Saben, P Kang, Y Zhong, KM Thakali, H Gomez-Acevedo, SJ Borengasser, A Andres, TM Badger, K Shankar |
Placenta | 2014 |
|
Life Without the Iodothyronine Deiodinases
VA Galton, E Waard, AF Parlow, DL st Germain, A Hernandez |
Endocrinology | 2014 |
|
Selenoproteins: Molecular Pathways and Physiological Roles
VM Labunskyy, DL Hatfield, VN Gladyshev |
Physiological reviews | 2014 |
|
Presence of Brown Adipose Tissue in an Adolescent With Severe Primary Hypothyroidism
MS Kim, HH Hu, PC Aggabao, ME Geffner, V Gilsanz |
The Journal of clinical endocrinology and metabolism | 2014 |
|
American Thyroid Association Guide to Investigating Thyroid Hormone Economy and Action in Rodent and Cell Models
AC Bianco, G Anderson, D Forrest, VA Dr, B Gereben, BW Kim, PA Kopp, XH Liao, MJ Obregon, R Peeters, S Refetoff, D Sharlin, WS Simonides, RE Weiss, G Williams |
Thyroid | 2013 |
|
The role of thyroid hormone and brown adipose tissue in energy homoeostasis
AC Bianco, EA McAninch |
The Lancet Diabetes & Endocrinology | 2013 |
|
Thyroid Hormones and the Metabolic Syndrome
KA Iwen, E Schröder, G Brabant |
European Thyroid Journal | 2013 |
|
Targeted Deletion of Fibrinogen Like Protein 1 Reveals a Novel Role in Energy Substrate Utilization
V Demchev, G Malana, D Vangala, J Stoll, A Desai, HW Kang, Y Li, H Nayeb-Hashemi, M Niepel, DE Cohen, C Ukomadu |
PloS one | 2013 |
|
Brown and beige fat: development, function and therapeutic potential
M Harms, P Seale |
Nature Medicine | 2013 |
|
Assessment of brown adipose tissue function
S Virtue, A Vidal-Puig |
Frontiers in physiology | 2013 |
|
The deiodinases and the control of intracellular thyroid hormone signaling during cellular differentiation☆
M Dentice, A Marsili, AM Zavacki, PR Larsen, D Salvatore |
Biochimica et Biophysica Acta | 2013 |
|
Metal Ions in Life Sciences
S Kurokawa, MJ Berry |
Metal ions in life sciences | 2013 |
|
NAT8L (N-Acetyltransferase 8-Like) Accelerates Lipid Turnover and Increases Energy Expenditure in Brown Adipocytes
AR Pessentheiner, HJ Pelzmann, E Walenta, M Schweiger, LN Groschner, WF Graier, D Kolb, K Uno, T Miyazaki, A Nitta, D Rieder, A Prokesch, JG Bogner-Strauss |
The Journal of biological chemistry | 2013 |
|
Cardiac Expression of Human Type 2 Iodothyronine Deiodinase Increases Glucose Metabolism and Protects Against Doxorubicin-induced Cardiac Dysfunction in Male Mice
EG Hong, BW Kim, DY Jung, JH Kim, T Yu, WS da Silva, RH Friedline, SD Bianco, SP Seslar, H Wakimoto, CI Berul, KS Russell, KW Lee, PR Larsen, AC Bianco, JK Kim |
Endocrinology | 2013 |
|
Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling
RA Drigo, TL Fonseca, JP Werneck-de-Castro, AC Bianco |
Biochimica et Biophysica Acta (BBA) - General Subjects | 2012 |
|
1 Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice
CB Ueta, GW Fernandes, LP Capelo, TL Fonseca, FD Maculan, CH Gouveia, PC Brum, MA Christoffolete, MS Aoki, CL Lancellotti, B Kim, AC Bianco, MO Ribeiro |
Journal of Endocrinology | 2012 |
|
Programming human pluripotent stem cells into white and brown adipocytes
T Ahfeldt, RT Schinzel, YK Lee, D Hendrickson, A Kaplan, DH Lum, R Camahort, F Xia, J Shay, EP Rhee, CB Clish, RC Deo, T Shen, FH Lau, A Cowley, G Mowrer, H Al-Siddiqi, M Nahrendorf, K Musunuru, RE Gerszten, JL Rinn, CA Cowan |
Nature Cell Biology | 2012 |
|
Thyroid Hormone Replacement Therapy: Three 'Simple' Questions, Complex Answers
AC Bianco, S Casula |
European Thyroid Journal | 2012 |
|
PPARγ activation attenuates cold-induced upregulation of thyroid status and brown adipose tissue PGC-1α and D2
WT Festuccia, PG Blanchard, TB Oliveira, J Magdalon, VA Paschoal, D Richard, Y Deshaies |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2012 |
|
Transient brown adipocyte-like cells derive from peripheral nerve progenitors in response to bone morphogenetic protein 2
EA Salisbury, ZW Lazard, EE Ubogu, AR Davis, EA Olmsted-Davis |
Stem Cells Translational Medicine | 2012 |
|
Dietary selenium and selenoprotein function.
Weeks BS, Hanna MS, Cooperstein D |
Medical science monitor : international medical journal of experimental and clinical research | 2012 |
|
Genetic Defect in Phospholipase Cδ1 Protects Mice From Obesity by Regulating Thermogenesis and Adipogenesis
M Hirata, M Suzuki, R Ishii, R Satow, T Uchida, T Kitazumi, T Sasaki, T Kitamura, H Yamaguchi, Y Nakamura, K Fukami |
Diabetes | 2011 |
|
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
|
Bioenergetic impact of tissue-specific regulation of iodothyronine deiodinases during nutritional imbalance
RL Araujo, DP Carvalho |
Journal of Bioenergetics and Biomembranes | 2011 |
|
The Implication of Brown Adipose Tissue for Humans
E Ravussin, JE Galgani |
Annual Review of Nutrition | 2011 |
|
The role of hypothalamic tri-iodothyronine availability in seasonal regulation of energy balance and body weight
M Murphy, FJ Ebling |
Journal of Thyroid Research | 2011 |
|
The Arrestin Domain-Containing 3 Protein Regulates Body Mass and Energy Expenditure
P Patwari, V Emilsson, EE Schadt, WA Chutkow, S Lee, A Marsili, Y Zhang, R Dobrin, DE Cohen, PR Larsen, AM Zavacki, LG Fong, SG Young, RT Lee |
Cell Metabolism | 2011 |
|
Recent progress in the study of brown adipose tissue
X Yao, S Shan, Y Zhang, H Ying |
Cell & Bioscience | 2011 |
|
Control of Brown Adipose Tissue Glucose and Lipid Metabolism by PPARγ
WT Festuccia, PG Blanchard, Y Deshaies |
Frontiers in Endocrinology | 2011 |
|
Minireview: Cracking the Metabolic Code for Thyroid Hormone Signaling
AC Bianco |
Endocrinology | 2011 |
|
Type-2 Iodothyronine 5′Deiodinase (D2) in Skeletal Muscle of C57Bl/6 Mice. II. Evidence for a Role of D2 in the Hypermetabolism of Thyroid Hormone Receptor α-Deficient Mice
W Ramadan, A Marsili, PR Larsen, AM Zavacki, JE Silva |
Endocrinology | 2011 |
|
Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure*
M Watanabe, Y Horai, SM Houten, K Morimoto, T Sugizaki, E Arita, C Mataki, H Sato, Y Tanigawara, K Schoonjans, H Itoh, J Auwerx |
The Journal of biological chemistry | 2011 |
|
Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure
BC de Jonghe, MR Hayes, R Banno, KP Skibicka, DJ Zimmer, KA Bowen, TM Leichner, AL Alhadeff, SE Kanoski, NE Cyr, EA Nillni, HJ Grill, KK Bence |
American journal of physiology. Endocrinology and metabolism | 2011 |
|
A Component of Retinal Light Adaptation Mediated by the Thyroid Hormone Cascade
DE Bedolla, V Torre |
PloS one | 2011 |
|
Physiological role and regulation of iodothyronine deiodinases: a 2011 update
A Marsili, AM Zavacki, JW Harney, PR Larsen |
Journal of Endocrinological Investigation | 2011 |
|
Type 2 deiodinase at the crossroads of thyroid hormone action
RA Drigo, AC Bianco |
The International Journal of Biochemistry & Cell Biology | 2011 |
|
Disruption of Thyroid Hormone Activation in Type 2 Deiodinase Knockout Mice Causes Obesity With Glucose Intolerance and Liver Steatosis Only at Thermoneutrality
M Castillo, JA Hall, M Correa-Medina, C Ueta, HW Kang, DE Cohen, AC Bianco |
Diabetes | 2011 |
|
Increased metabolic rate and insulin sensitivity in male mice lacking the carcino-embryonic antigen-related cell adhesion molecule 2
PR Patel, SK Ramakrishnan, MK Kaw, CK Raphael, S Ghosh, JS Marino, G Heinrich, SJ Lee, RE Bourey, JW Hill, DY Jung, DA Morgan, JK Kim, SK Rahmouni, SM Najjar |
Diabetologia | 2011 |
|
Mice with a Targeted Deletion of the Type 2 Deiodinase Are Insulin Resistant and Susceptible to Diet Induced Obesity
A Marsili, C Aguayo-Mazzucato, T Chen, A Kumar, M Chung, EP Lunsford, JW Harney, T Van-Tran, E Gianetti, W Ramadan, C Chou, S Bonner-Weir, PR Larsen, JE Silva, AM Zavacki, A Bartolomucci |
PloS one | 2011 |
|
The Nuclear Receptor Corepressor (NCoR) Controls Thyroid Hormone Sensitivity and the Set Point of the Hypothalamic-Pituitary-Thyroid Axis
I Astapova, KR Vella, P Ramadoss, KA Holtz, BA Rodwin, XH Liao, RE Weiss, MA Rosenberg, A Rosenzweig, AN Hollenberg |
Molecular Endocrinology | 2011 |
|
Physiological role and regulation of iodothyronine deiodinases: a 2011 update.
Marsili A, Zavacki AM, Harney JW, Larsen PR |
Journal of Endocrinological Investigation | 2011 |
|
Regulation of the hypothalamic Thyrotropin Releasing Hormone (TRH) neuron by neuronal and peripheral inputs
EA Nillni |
Frontiers in Neuroendocrinology | 2010 |
|
Impaired metabolic effects of a thyroid hormone receptor beta-selective agonist in a mouse model of diet-induced obesity
M Castillo, BC Freitas, ML Rosene, RA Drigo, R Grozovsky, RM Maciel, ME Patti, MO Ribeiro, AC Bianco |
Thyroid : official journal of the American Thyroid Association | 2010 |
|
New insights into thyroid hormone replacement therapy
BM Acosta, AC Bianco |
F1000 medicine reports | 2010 |
|
Food deprivation alters thermoregulatory responses to lipopolysaccharide by enhancing cryogenic inflammatory signaling via prostaglandin D2
CM Krall, X Yao, MA Hass, C Feleder, AA Steiner |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2010 |
|
Insulin Represses Transcription of the Thyroid Stimulating Hormone β-Subunit Gene through Increased Recruitment of Nuclear Factor I*
KK Kim, KS Park, SB Song, KE Kim |
The Journal of biological chemistry | 2010 |
|
Absence of Thyroid Hormone Activation during Development Underlies a Permanent Defect in Adaptive Thermogenesis
JA Hall, S Ribich, MA Christoffolete, G Simovic, M Correa-Medina, ME Patti, AC Bianco |
Endocrinology | 2010 |
|
Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity
H Sampath, MT Flowers, X Liu, CM Paton, R Sullivan, K Chu, M Zhao, JM Ntambi |
The Journal of biological chemistry | 2009 |
|
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
|
Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-beta isoform specific and required for adaptive thermogenesis
MO Ribeiro, SD Bianco, M Kaneshige, JJ Schultz, S Cheng, AC Bianco, GA Brent |
Endocrinology | 2009 |
|
The human selenoproteome: recent insights into functions and regulation
MA Reeves, PR Hoffmann |
Cellular and Molecular Life Sciences | 2009 |
|
Thyroid Hormone Activation in Vascular Smooth Muscle Cells Is Negatively Regulated by Glucocorticoid
N Toyoda, S Yasuzawa-Amano, E Nomura, A Yamauchi, K Nishimura, C Ukita, S Morimoto, A Kosaki, T Iwasaka, JW Harney, PR Larsen, M Nishikawa |
Thyroid | 2009 |
|
Endocrine disrupters as obesogens
F Grün, B Blumberg |
Molecular and Cellular Endocrinology | 2009 |
|
Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue
Y Cheng, Q Meng, C Wang, H Li, Z Huang, S Chen, F Xiao, F Guo |
Diabetes | 2009 |
|
Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue
HW Kang, S Ribich, BW Kim, SJ Hagen, AC Bianco, DE Cohen |
Journal of lipid research | 2009 |
|
Triumphs of the Thyroid Despite Lesser Conversion
JA Hall, AC Bianco |
Endocrinology | 2009 |
|
Minireview: The Case for Obesogens
F Grün, B Blumberg |
Molecular Endocrinology | 2009 |
|
Life without Thyroxine to 3,5,3′-Triiodothyronine Conversion: Studies in Mice Devoid of the 5′-Deiodinases
VA Galton, MJ Schneider, AS Clark, DL Germain |
Endocrinology | 2009 |
|
Defining the Roles of the Iodothyronine Deiodinases: Current Concepts and Challenges
DL Germain, VA Galton, A Hernandez |
Endocrinology | 2009 |
|
Hypoxia-inducible factor induces local thyroid hormone inactivation in hypoxic-ischemic disease
1. Warner S. Simonides 2. Michelle A. Mulcahey 3. Everaldo M. Redout 4. Alice Muller 5. Marian J. Zuidwijk 6. Theo J. Visser 7. Frank W.J.S. Wassen 8. Alessandra Crescenzi 9. Wagner S. da-Silva 10. John Harney 11. Felix B. Engel 12. Maria-Jesús Obregon 13. P. Reed Larsen 14. Antonio C. Bianco 15. Stephen A. Huang |
Journal of Clinical Investigation | 2008 |
|
Reawakened interest in type III iodothyronine deiodinase in critical illness and injury
SA Huang, AC Bianco |
Nature Clinical Practice Endocrinology & Metabolism | 2008 |
|
Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling1
B Gereben, AM Zavacki, S Ribich, BW Kim, SA Huang, WS Simonides, A Zeöld, AC Bianco |
Endocrine reviews | 2008 |
|
Type 2 Deiodinase Expression Is Induced by Peroxisomal Proliferator-Activated Receptor-γ Agonists in Skeletal Myocytes
R Grozovsky, S Ribich, ML Rosene, MA Mulcahey, SA Huang, ME Patti, AC Bianco, BW Kim |
Endocrinology | 2008 |
|
Cardiomyocyte-specific inactivation of thyroid hormone in pathologic ventricular hypertrophy: an adaptative response or part of the problem?
CJ Pol, A Muller, WS Simonides |
Heart Failure Reviews | 2008 |
|
The brown adipocyte differentiation pathway in birds: an evolutionary road not taken
NV Mezentseva, JS Kumaratilake, SA Newman |
BMC Biology | 2008 |
|
Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis
M Angers, M Uldry, D Kong, JM Gimble, AM Jetten |
Biochemical Journal | 2008 |
|
Negative feedback regulation of hypophysiotropic thyrotropin-releasing hormone (TRH) synthesizing neurons: role of neuronal afferents and type 2 deiodinase
C Fekete, RM Lechan |
Frontiers in Neuroendocrinology | 2007 |
|
PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis
J Sonoda, IR Mehl, LW Chong, RR Nofsinger, RM Evans |
Proceedings of the National Academy of Sciences | 2007 |
|
Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis
JA Villena, MB Hock, WY Chang, JE Barcas, V Giguère, A Kralli |
Proceedings of the National Academy of Sciences | 2007 |
|
Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure
N Dali-Youcef, C Mataki, A Coste, N Messaddeq, S Giroud, S Blanc, C Koehl, MF Champy, P Chambon, L Fajas, D Metzger, K Schoonjans, J Auwerx |
Proceedings of the National Academy of Sciences | 2007 |
|
Selenoprotein expression is essential in endothelial cell development and cardiac muscle function
RK Shrimali, JA Weaver, GF Miller, MF Starost, BA Carlson, SV Novoselov, E Kumaraswamy, VN Gladyshev, DL Hatfield |
Neuromuscular Disorders | 2007 |
|
Deiodinases: Implications of the local control of thyroid hormone action
Antonio C. Bianco and Brian W. Kim |
Journal of Clinical Investigation | 2006 |
|
Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase
L Ng, RJ Goodyear, CA Woods, MJ Schneider, E Diamond, GP Richardson, MW Kelley, DL st Germain, VA Galton, D Forrest |
Proceedings of the National Academy of Sciences | 2004 |
|
Deubiquitination of type 2 iodothyronine deiodinase by pVHL-interacting deubiquitinating enzymes regulates thyroid hormone activation
Cyntia Curcio-Morelli, Ann Marie Zavacki, Marcelo Christofollete, Balazs Gereben, Beatriz C.G. de Freitas, John W. Harney, Zaibo Li, Guan Wu and Antonio C. Bianco |
Journal of Clinical Investigation | 2003 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)