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Citations to this article

The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue
Lucia A. de Jesus, … , P. Reed Larsen, Antonio C. Bianco
Lucia A. de Jesus, … , P. Reed Larsen, Antonio C. Bianco
Published November 1, 2001
Citation Information: J Clin Invest. 2001;108(9):1379-1385. https://doi.org/10.1172/JCI13803.
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The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue

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Abstract

Type 2 iodothyronine deiodinase (D2) is a selenoenzyme, the product of the recently cloned cAMP-dependent Dio2 gene, which increases 10- to 50-fold during cold stress only in brown adipose tissue (BAT). Here we report that despite a normal plasma 3,5,3′-triiodothyronine (T3) concentration, cold-exposed mice with targeted disruption of the Dio2 gene (Dio2–/–) become hypothermic due to impaired BAT thermogenesis and survive by compensatory shivering with consequent acute weight loss. This occurs despite normal basal mitochondrial uncoupling protein 1 (UCP1) concentration. In Dio2–/– brown adipocytes, the acute norepinephrine-, CL316,243-, or forskolin-induced increases in lipolysis, UCP1 mRNA, and O2 consumption are all reduced due to impaired cAMP generation. These hypothyroid-like abnormalities are completely reversed by a single injection of T3 14 hours earlier. Recent studies suggest that UCP1 is primarily dependent on thyroid hormone receptor β (TRβ) while the normal sympathetic response of brown adipocytes requires TRα. Intracellularly generated T3 may be required to saturate the TRα, which has an approximately fourfold lower T3-binding affinity than does TRβ. Thus, D2 is an essential component in the thyroid-sympathetic synergism required for thermal homeostasis in small mammals.

Authors

Lucia A. de Jesus, Suzy D. Carvalho, Mirian O. Ribeiro, Mark Schneider, Sung-Woo Kim, John W. Harney, P. Reed Larsen, Antonio C. Bianco

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2004 2003 Total
Citations: 2 11 15 18 26 11 15 20 7 18 15 18 10 7 20 6 12 7 5 1 1 1 246
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Citations to this article in year 2016 (18)

Title and authors Publication Year
Brown adipose tissue transplantation ameliorates polycystic ovary syndrome
X Yuan, T Hu, H Zhao, Y Huang, R Ye, J Lin, C Zhang, H Zhang, G Wei, H Zhou, M Dong, J Zhao, H Wang, Q Liu, HJ Lee, W Jin, ZJ Chen
Proceedings of the National Academy of Sciences 2016
Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity
A Caron, SM Labbé, D Lanfray, PG Blanchard, R Villot, C Roy, DM Sabatini, D Richard, M Laplante
Molecular Metabolism 2016
Uncoupling Proteins and the Molecular Mechanisms of Thyroid Thermogenesis
A Solmonson, EM Mills
Endocrinology 2016
Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice
J Weiner, M Kranz, N Klöting, A Kunath, K Steinhoff, E Rijntjes, J Köhrle, V Zeisig, M Hankir, C Gebhardt, W Deuther-Conrad, JT Heiker, S Kralisch, M Stumvoll, M Blüher, O Sabri, S Hesse, P Brust, A Tönjes, K Krause
Scientific Reports 2016
The role of innate immunity in the regulation of brown and beige adipogenesis
VI Alexaki, T Chavakis
Reviews in Endocrine and Metabolic Disorders 2016
Targeting iodothyronine deiodinases locally in the retina is a therapeutic strategy for retinal degeneration
F Yang, H Ma, J Belcher, MR Butler, TM Redmond, SL Boye, WW Hauswirth, XQ Ding
The FASEB Journal 2016
Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue
CM Tran, S Mukherjee, L Ye, DW Frederick, M Kissig, JG Davis, DW Lamming, P Seale, JA Baur
Diabetes 2016
Altered Microbiota Contributes to Reduced Diet-Induced Obesity upon Cold Exposure
M Ziętak, P Kovatcheva-Datchary, LH Markiewicz, M Ståhlman, LP Kozak, F Bäckhed
Cell Metabolism 2016
AHNAK deficiency promotes browning and lipolysis in mice via increased responsiveness to β-adrenergic signalling
JH Shin, SH Lee, YN Kim, IY Kim, YJ Kim, DS Kyeong, HJ Lim, SY Cho, J Choi, YJ Wi, JH Choi, YS Yoon, YS Bae, JK Seong
Scientific Reports 2016
Selenium and Metabolic Disorders: An Emphasis on Type 2 Diabetes Risk
AN Ogawa-Wong, MJ Berry, LA Seale
Nutrients 2016
Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice
BM Bocco, GW Fernandes, FB Lorena, RM Cysneiros, MA Christoffolete, SS Grecco, CL Lancellotti, P Romoff, JH Lago, AC Bianco, MO Ribeiro
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] 2016
Thyroid Hormone Activates Brown Adipose Tissue and Increases Non-Shivering Thermogenesis - A Cohort Study in a Group of Thyroid Carcinoma Patients
EP Broeders, GH Vijgen, B Havekes, ND Bouvy, FM Mottaghy, M Kars, NC Schaper, P Schrauwen, B Brans, WD van Lichtenbelt, J Ye
PloS one 2016
Endocannabinoid regulation in white and brown adipose tissue following thermogenic activation
LM Krott, F Piscitelli, M Heine, S Borrino, L Scheja, C Silvestri, J Heeren, VD Marzo
Journal of lipid research 2016
The effects on weight loss and gene expression in adipose and hepatic tissues of very-low carbohydrate and low-fat isoenergetic diets in diet-induced obese mice
T Yamazaki, S Okawa, M Takahashi
Nutrition & Metabolism 2016
Attenuation of diet-induced obesity and induction of white fat browning with a chemical inhibitor of histone deacetylases
A Ferrari, E Fiorino, R Longo, S Barilla, N Mitro, G Cermenati, M Giudici, D Caruso, A Mai, U Guerrini, ED Fabiani, M Crestani
International Journal of Obesity 2016
Ldb1 Regulates Energy Homeostasis During Diet-Induced Obesity
C Loyd, Y Liu, T Kim, C Holleman, J Galloway, M Bethea, BN Ediger, Y Tang, TA Swain, DA Stoffers, GC Rowe, M Young, C Steele, KM Habegger, CS Hunter
Endocrinology 2016
Brown adipose tissue: The heat is on the heart
R Thoonen, AG Hindle, M Scherrer-Crosbie
American journal of physiology. Heart and circulatory physiology 2016
Classification of Therapeutic and Experimental Drugs for Brown Adipose Tissue Activation: Potential Treatment Strategies for Diabetes and Obesity
Mukherjee J, Baranwal A, Schade KN
Current diabetes reviews 2016

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