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Citations to this article

The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue
Lucia A. de Jesus, … , P. Reed Larsen, Antonio C. Bianco
Lucia A. de Jesus, … , P. Reed Larsen, Antonio C. Bianco
Published November 1, 2001
Citation Information: J Clin Invest. 2001;108(9):1379-1385. https://doi.org/10.1172/JCI13803.
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The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue

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Abstract

Type 2 iodothyronine deiodinase (D2) is a selenoenzyme, the product of the recently cloned cAMP-dependent Dio2 gene, which increases 10- to 50-fold during cold stress only in brown adipose tissue (BAT). Here we report that despite a normal plasma 3,5,3′-triiodothyronine (T3) concentration, cold-exposed mice with targeted disruption of the Dio2 gene (Dio2–/–) become hypothermic due to impaired BAT thermogenesis and survive by compensatory shivering with consequent acute weight loss. This occurs despite normal basal mitochondrial uncoupling protein 1 (UCP1) concentration. In Dio2–/– brown adipocytes, the acute norepinephrine-, CL316,243-, or forskolin-induced increases in lipolysis, UCP1 mRNA, and O2 consumption are all reduced due to impaired cAMP generation. These hypothyroid-like abnormalities are completely reversed by a single injection of T3 14 hours earlier. Recent studies suggest that UCP1 is primarily dependent on thyroid hormone receptor β (TRβ) while the normal sympathetic response of brown adipocytes requires TRα. Intracellularly generated T3 may be required to saturate the TRα, which has an approximately fourfold lower T3-binding affinity than does TRβ. Thus, D2 is an essential component in the thyroid-sympathetic synergism required for thermal homeostasis in small mammals.

Authors

Lucia A. de Jesus, Suzy D. Carvalho, Mirian O. Ribeiro, Mark Schneider, Sung-Woo Kim, John W. Harney, P. Reed Larsen, Antonio C. Bianco

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2004 2003 Total
Citations: 2 11 15 18 26 11 15 20 7 18 15 18 10 7 20 6 12 7 5 1 1 1 246
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2013 (10)

Title and authors Publication Year
American Thyroid Association Guide to Investigating Thyroid Hormone Economy and Action in Rodent and Cell Models
AC Bianco, G Anderson, D Forrest, VA Dr, B Gereben, BW Kim, PA Kopp, XH Liao, MJ Obregon, R Peeters, S Refetoff, D Sharlin, WS Simonides, RE Weiss, G Williams
Thyroid 2013
The role of thyroid hormone and brown adipose tissue in energy homoeostasis
AC Bianco, EA McAninch
The Lancet Diabetes & Endocrinology 2013
Thyroid Hormones and the Metabolic Syndrome
KA Iwen, E Schröder, G Brabant
European Thyroid Journal 2013
Targeted Deletion of Fibrinogen Like Protein 1 Reveals a Novel Role in Energy Substrate Utilization
V Demchev, G Malana, D Vangala, J Stoll, A Desai, HW Kang, Y Li, H Nayeb-Hashemi, M Niepel, DE Cohen, C Ukomadu
PloS one 2013
Brown and beige fat: development, function and therapeutic potential
M Harms, P Seale
Nature Medicine 2013
Assessment of brown adipose tissue function
S Virtue, A Vidal-Puig
Frontiers in physiology 2013
The deiodinases and the control of intracellular thyroid hormone signaling during cellular differentiation☆
M Dentice, A Marsili, AM Zavacki, PR Larsen, D Salvatore
Biochimica et Biophysica Acta 2013
Metal Ions in Life Sciences
S Kurokawa, MJ Berry
Metal ions in life sciences 2013
NAT8L (N-Acetyltransferase 8-Like) Accelerates Lipid Turnover and Increases Energy Expenditure in Brown Adipocytes
AR Pessentheiner, HJ Pelzmann, E Walenta, M Schweiger, LN Groschner, WF Graier, D Kolb, K Uno, T Miyazaki, A Nitta, D Rieder, A Prokesch, JG Bogner-Strauss
The Journal of biological chemistry 2013
Cardiac Expression of Human Type 2 Iodothyronine Deiodinase Increases Glucose Metabolism and Protects Against Doxorubicin-induced Cardiac Dysfunction in Male Mice
EG Hong, BW Kim, DY Jung, JH Kim, T Yu, WS da Silva, RH Friedline, SD Bianco, SP Seslar, H Wakimoto, CI Berul, KS Russell, KW Lee, PR Larsen, AC Bianco, JK Kim
Endocrinology 2013

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