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Citations to this article

The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue
Lucia A. de Jesus, … , P. Reed Larsen, Antonio C. Bianco
Lucia A. de Jesus, … , P. Reed Larsen, Antonio C. Bianco
Published November 1, 2001
Citation Information: J Clin Invest. 2001;108(9):1379-1385. https://doi.org/10.1172/JCI13803.
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The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue

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Abstract

Type 2 iodothyronine deiodinase (D2) is a selenoenzyme, the product of the recently cloned cAMP-dependent Dio2 gene, which increases 10- to 50-fold during cold stress only in brown adipose tissue (BAT). Here we report that despite a normal plasma 3,5,3′-triiodothyronine (T3) concentration, cold-exposed mice with targeted disruption of the Dio2 gene (Dio2–/–) become hypothermic due to impaired BAT thermogenesis and survive by compensatory shivering with consequent acute weight loss. This occurs despite normal basal mitochondrial uncoupling protein 1 (UCP1) concentration. In Dio2–/– brown adipocytes, the acute norepinephrine-, CL316,243-, or forskolin-induced increases in lipolysis, UCP1 mRNA, and O2 consumption are all reduced due to impaired cAMP generation. These hypothyroid-like abnormalities are completely reversed by a single injection of T3 14 hours earlier. Recent studies suggest that UCP1 is primarily dependent on thyroid hormone receptor β (TRβ) while the normal sympathetic response of brown adipocytes requires TRα. Intracellularly generated T3 may be required to saturate the TRα, which has an approximately fourfold lower T3-binding affinity than does TRβ. Thus, D2 is an essential component in the thyroid-sympathetic synergism required for thermal homeostasis in small mammals.

Authors

Lucia A. de Jesus, Suzy D. Carvalho, Mirian O. Ribeiro, Mark Schneider, Sung-Woo Kim, John W. Harney, P. Reed Larsen, Antonio C. Bianco

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TRH Neurons and Thyroid Hormone Coordinate the Hypothalamic Response to Cold
Z Zhang, A Boelen, A Kalsbeek, E Fliers
European Thyroid Journal 2018
Natriuretic peptides promote glucose uptake in a cGMP-dependent manner in human adipocytes
M Coué, V Barquissau, P Morigny, K Louche, C Lefort, A Mairal, C Carpéné, N Viguerie, P Arner, D Langin, M Rydén, C Moro
Scientific Reports 2018
Evaluation and optimization of differentiation conditions for human primary brown adipocytes
XY Wang, LH You, XW Cui, Y Li, X Wang, PF Xu, LJ Zhu, J Wen, LX Pang, XR Guo, CB Ji
Scientific Reports 2018
Central regulation of energy metabolism by estrogens
Y Xu, M López
Molecular Metabolism 2018
Do TSH, FT3, and FT4 Impact BAT Visualization of Clinical FDG-PET/CT Images?
R Nishii, S Nagamachi, Y Mizutani, T Terada, S Kiyohara, H Wakamatsu, S Fujita, T Higashi, K Yoshinaga, T Saga, T Hirai
Contrast Media & Molecular Imaging 2018
Metabolic Effects of the Intracellular Regulation of Thyroid Hormone: Old Players, New Concepts
AG Cicatiello, DD Girolamo, M Dentice
Frontiers in Endocrinology 2018
Low temperature exposure induces browning of bone marrow stem cell derived adipocytes in vitro
K Velickovic, HA Leija, I Bloor, J Law, H Sacks, M Symonds, V Sottile
Scientific Reports 2018
Adipocyte DIO2 Expression Increases in Human Obesity but Is Not Related to Systemic Insulin Sensitivity
D Bradley, J Liu, A Blaszczak, V Wright, A Jalilvand, B Needleman, S Noria, D Renton, W Hsueh
Journal of Diabetes Research 2018
FGF21 decreases body weight without reducing food intake or bone mineral density in high-fat fed obese rhesus macaque monkeys
B Andersen, EM Straarup, KM Heppner, DL Takahashi, V Raffaele, GA Dissen, K Lewandowski, TB Bödvarsdottir, K Raun, KL Grove, P Kievit
International Journal of Obesity 2018
NT-PGC-1α deficiency decreases mitochondrial FA oxidation in brown adipose tissue and alters substrate utilization in vivo
J Kim, MS Park, K Ha, C Park, J Lee, RL Mynatt, JS Chang
Journal of lipid research 2018
Effect of Iodothyronines on Thermogenesis: Focus on Brown Adipose Tissue
F Cioffi, A Gentile, E Silvestri, F Goglia, A Lombardi
Frontiers in Endocrinology 2018
Promotion of lipid storage rather than of thermogenic competence by fetal versus newborn calf serum in primary cultures of brown adipocytes
JM de Jong, B Cannon, J Nedergaard
Adipocyte 2018
Lipoprotein Lipase Expression in Hypothalamus Is Involved in the Central Regulation of Thermogenesis and the Response to Cold Exposure
E Laperrousaz, RG Denis, N Kassis, C Contreras, M López, S Luquet, C Cruciani-Guglielmacci, C Magnan
Frontiers in Endocrinology 2018
Deficiency of type 2 iodothyronine deiodinase reduces necroptosis activity and oxidative stress responses in retinas of Leber congenital amaurosis model mice
F Yang, H Ma, MR Butler,
The FASEB Journal 2018
Deficiency in interleukin-18 promotes differentiation of brown adipose tissue resulting in fat accumulation despite dyslipidemia
K Yamanishi, S Maeda, S Kuwahara-Otani, T Hashimoto, K Ikubo, K Mukai, K Nakasho, N Gamachi, Y El-Darawish, W Li, D Okuzaki, Y Watanabe, H Yamanishi, H Okamura, H Matsunaga
Journal of Translational Medicine 2018
Thyroid hormone (T 3 ) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy
WW Yau, BK Singh, R Lesmana, J Zhou, RA Sinha, KA Wong, Y Wu, BH Bay, S Sugii, L Sun, PM Yen
Autophagy 2018
Switching harmful visceral fat to beneficial energy combustion improves metabolic dysfunctions
Xiaoyan Yang, Wenhai Sui, Meng Zhang, Mei Dong, Sharon Lim, Takahiro Seki, Ziheng Guo, Carina Fischer, Huixia Lu, Cheng Zhang, Jianmin Yang, Meng Zhang, Yangang Wang, Caixia Cao, Yanyan Gao, Xingguo Zhao, Meili Sun, Yuping Sun, Rujie Zhuang, Nilesh Samani, Yun Zhang, Yihai Cao
JCI Insight 2017
Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function
G Yu, A Tzouvelekis, R Wang, JD Herazo-Maya, GH Ibarra, A Srivastava, JP de Castro, G DeIuliis, F Ahangari, T Woolard, N Aurelien, RA Drigo, Y Gan, M Graham, X Liu, RJ Homer, TS Scanlan, P Mannam, PJ Lee, EL Herzog, AC Bianco, N Kaminski
Nature Medicine 2017
A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes
L Shu, RL Hoo, X Wu, Y Pan, IP Lee, LY Cheong, SR Bornstein, X Rong, J Guo, A Xu
Nature Communications 2017
White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function
YW Chung, F Ahmad, Y Tang, SC Hockman, HJ Kee, K Berger, E Guirguis, YH Choi, DM Schimel, AM Aponte, S Park, E Degerman, VC Manganiello
Scientific Reports 2017
Remodeling of rat stromal-vascular cells to brite/beige adipocytes by prolyl-hydroxyproline
JA MINAGUCHI, S OGATA, N TAKAHASHI, T HIROSE, H UEDA, K TAKEHANA
Journal of Veterinary Medical Science 2017
Age-dependent insulin resistance in male mice with null deletion of the carcinoembryonic antigen-related cell adhesion molecule 2 gene
SS Ghanem, HT Muturi, AM DeAngelis, J Hu, RN Kulkarni, G Heinrich, SM Najjar
Diabetologia 2017
Egr1 deficiency induces browning of inguinal subcutaneous white adipose tissue in mice
C Milet, M Bléher, K Allbright, M Orgeur, F Coulpier, D Duprez, E Havis
Scientific Reports 2017
Brown adipose tissue transplantation ameliorates polycystic ovary syndrome
X Yuan, T Hu, H Zhao, Y Huang, R Ye, J Lin, C Zhang, H Zhang, G Wei, H Zhou, M Dong, J Zhao, H Wang, Q Liu, HJ Lee, W Jin, ZJ Chen
Proceedings of the National Academy of Sciences 2016
Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity
A Caron, SM Labbé, D Lanfray, PG Blanchard, R Villot, C Roy, DM Sabatini, D Richard, M Laplante
Molecular Metabolism 2016
Uncoupling Proteins and the Molecular Mechanisms of Thyroid Thermogenesis
A Solmonson, EM Mills
Endocrinology 2016
Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice
J Weiner, M Kranz, N Klöting, A Kunath, K Steinhoff, E Rijntjes, J Köhrle, V Zeisig, M Hankir, C Gebhardt, W Deuther-Conrad, JT Heiker, S Kralisch, M Stumvoll, M Blüher, O Sabri, S Hesse, P Brust, A Tönjes, K Krause
Scientific Reports 2016
The role of innate immunity in the regulation of brown and beige adipogenesis
VI Alexaki, T Chavakis
Reviews in Endocrine and Metabolic Disorders 2016
Targeting iodothyronine deiodinases locally in the retina is a therapeutic strategy for retinal degeneration
F Yang, H Ma, J Belcher, MR Butler, TM Redmond, SL Boye, WW Hauswirth, XQ Ding
The FASEB Journal 2016
Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue
CM Tran, S Mukherjee, L Ye, DW Frederick, M Kissig, JG Davis, DW Lamming, P Seale, JA Baur
Diabetes 2016
Altered Microbiota Contributes to Reduced Diet-Induced Obesity upon Cold Exposure
M Ziętak, P Kovatcheva-Datchary, LH Markiewicz, M Ståhlman, LP Kozak, F Bäckhed
Cell Metabolism 2016
AHNAK deficiency promotes browning and lipolysis in mice via increased responsiveness to β-adrenergic signalling
JH Shin, SH Lee, YN Kim, IY Kim, YJ Kim, DS Kyeong, HJ Lim, SY Cho, J Choi, YJ Wi, JH Choi, YS Yoon, YS Bae, JK Seong
Scientific Reports 2016
Selenium and Metabolic Disorders: An Emphasis on Type 2 Diabetes Risk
AN Ogawa-Wong, MJ Berry, LA Seale
Nutrients 2016
Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice
BM Bocco, GW Fernandes, FB Lorena, RM Cysneiros, MA Christoffolete, SS Grecco, CL Lancellotti, P Romoff, JH Lago, AC Bianco, MO Ribeiro
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] 2016
Thyroid Hormone Activates Brown Adipose Tissue and Increases Non-Shivering Thermogenesis - A Cohort Study in a Group of Thyroid Carcinoma Patients
EP Broeders, GH Vijgen, B Havekes, ND Bouvy, FM Mottaghy, M Kars, NC Schaper, P Schrauwen, B Brans, WD van Lichtenbelt, J Ye
PloS one 2016
Endocannabinoid regulation in white and brown adipose tissue following thermogenic activation
LM Krott, F Piscitelli, M Heine, S Borrino, L Scheja, C Silvestri, J Heeren, VD Marzo
Journal of lipid research 2016
The effects on weight loss and gene expression in adipose and hepatic tissues of very-low carbohydrate and low-fat isoenergetic diets in diet-induced obese mice
T Yamazaki, S Okawa, M Takahashi
Nutrition & Metabolism 2016
Attenuation of diet-induced obesity and induction of white fat browning with a chemical inhibitor of histone deacetylases
A Ferrari, E Fiorino, R Longo, S Barilla, N Mitro, G Cermenati, M Giudici, D Caruso, A Mai, U Guerrini, ED Fabiani, M Crestani
International Journal of Obesity 2016
Ldb1 Regulates Energy Homeostasis During Diet-Induced Obesity
C Loyd, Y Liu, T Kim, C Holleman, J Galloway, M Bethea, BN Ediger, Y Tang, TA Swain, DA Stoffers, GC Rowe, M Young, C Steele, KM Habegger, CS Hunter
Endocrinology 2016
Brown adipose tissue: The heat is on the heart
R Thoonen, AG Hindle, M Scherrer-Crosbie
American journal of physiology. Heart and circulatory physiology 2016
Classification of Therapeutic and Experimental Drugs for Brown Adipose Tissue Activation: Potential Treatment Strategies for Diabetes and Obesity
Mukherjee J, Baranwal A, Schade KN
Current diabetes reviews 2016
Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance
AL Poher, J Altirriba, C Veyrat-Durebex, FÃ Rohner-Jeanrenaud
Frontiers in physiology 2015
Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue
G Godlewski, T Jourdan, G Szanda, J Tam, R Cinar, J Harvey-White, J Liu, B Mukhopadhyay, P Pacher, FM Mo, D Osei-Hyiaman, G Kunos
Scientific Reports 2015
Obesity is associated with a decrease in expression but not with the hypermethylation of thermogenesis-related genes in adipose tissues
A Kurylowicz, M Jonas, W Lisik, M Jonas, ZA Wicik, Z Wierzbicki, A Chmura, M Puzianowska-Kuznicka
Journal of Translational Medicine 2015
The Selective Loss of the Type 2 Iodothyronine Deiodinase in Mouse Thyrotrophs Increases Basal TSH but Blunts the Thyrotropin Response to Hypothyroidism
C Luongo, C Martin, K Vella, A Marsili, R Ambrosio, M Dentice, JW Harney, D Salvatore, AM Zavacki, PR Larsen
Endocrinology 2015
Low Temperature-Induced Circulating Triiodothyronine Accelerates Seasonal Testicular Regression
K Ikegami, Y Atsumi, E Yorinaga, H Ono, I Murayama, Y Nakane, W Ota, N Arai, A Tega, M Iigo, VM Darras, K Tsutsui, Y Hayashi, S Yoshida, T Yoshimura
Endocrinology 2015
Absence of Intracellular Ion Channels TPC1 and TPC2 Leads to Mature-Onset Obesity in Male Mice, Due to Impaired Lipid Availability for Thermogenesis in Brown Adipose Tissue
PV Lear, D González-Touceda, BP Couto, P Viaño, V Guymer, E Remzova, R Tunn, A Chalasani, T García-Caballero, IP Hargreaves, PW Tynan, HC Christian, R Nogueiras, J Parrington, C Diéguez
Endocrinology 2015
The brown fat secretome: metabolic functions beyond thermogenesis
GX Wang, XY Zhao, JD Lin
Trends in Endocrinology & Metabolism 2015
De novo lipogenesis in metabolic homeostasis: More friend than foe?
G Solinas, J Borén, AG Dulloo
Molecular Metabolism 2015
Role of Energy Metabolism in the Brown Fat Gene Program
M Nam, MP Cooper
Frontiers in Endocrinology 2015
Non-sympathetic control of brown adipose tissue
R Cereijo, J Villarroya, F Villarroya
International Journal of Obesity Supplements 2015
Effects of Mild Chronic Intermittent Cold Exposure on Rat Organs
X Wang, H Che, W Zhang, J Wang, T Ke, R Cao, S Meng, D Li, O Weiming, J Chen, W Luo
International journal of biological sciences 2015
A New Role for Browning as a Redox and Stress Adaptive Mechanism?
Y Jeanson, A Carrière, L Casteilla
Frontiers in Endocrinology 2015
The brown and brite adipocyte marker Cox7a1 is not required for non-shivering thermogenesis in mice
SF Maurer, T Fromme, LI Grossman, M Hüttemann, M Klingenspor
Scientific Reports 2015
The sympathetic nervous system is controlled by transient receptor potential vanilloid 1 in the regulation of body temperature
KM Alawi, AA Aubdool, L Liang, E Wilde, A Vepa, MP Psefteli, SD Brain, JE Keeble
The FASEB Journal 2015
Bile acids induce uncoupling protein 1-dependent thermogenesis and stimulate energy expenditure at thermoneutrality in mice
M Zietak, LP Kozak
American journal of physiology. Endocrinology and metabolism 2015
Moderate calorie restriction during gestation programs offspring for lower BAT thermogenic capacity driven by thyroid and sympathetic signaling
M Palou, T Priego, M Romero, N Szostaczuk, J Konieczna, C Cabrer, X Remesar, A Palou, C Pico
International Journal of Obesity 2014
Inactivation of the adrenergic receptor  2 disrupts glucose homeostasis in mice
GW Fernandes, CB Ueta, TL Fonseca, CH Gouveia, CL Lancellotti, PC Brum, MA Christoffolete, AC Bianco, MO Ribeiro
Journal of Endocrinology 2014
Thyroid Hormone Regulation of Metabolism
R Mullur, YY Liu, GA Brent
Physiological reviews 2014
The brain and brown fat
C Contreras, F Gonzalez, J Fernø, C Diéguez, K Rahmouni, R Nogueiras, M López
Annals of Medicine 2014
Triiodothyronine regulates distribution of thyroid hormone receptors by activating AMP-activated protein kinase in 3T3-L1 adipocytes and induces uncoupling protein-1 expression
CZ Wang, D Wei, MP Guan, YM Xue
Molecular and Cellular Biochemistry 2014
Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice
MJ Harms, J Ishibashi, W Wang, HW Lim, S Goyama, T Sato, M Kurokawa, KJ Won, P Seale
Cell Metabolism 2014
Brown fat fuel utilization and thermogenesis
KL Townsend, YH Tseng
Trends in Endocrinology & Metabolism 2014
Dietary Fucoxanthin Increases Metabolic Rate and Upregulated mRNA Expressions of the PGC-1alpha Network, Mitochondrial Biogenesis and Fusion Genes in White Adipose Tissues of Mice
MT Wu, HN Chou, C Huang
Marine drugs 2014
Selenoproteins in Nervous System Development and Function
MW Pitts, CN Byrns, AN Ogawa-Wong, P Kremer, MJ Berry
Biological Trace Element Research 2014
Abnormal motor phenotype at adult stages in mice lacking type 2 deiodinase
S Bárez-López, D Bosch-García, D Gómez-Andrés, I Pulido-Valdeolivas, A Montero-Pedrazuela, MJ Obregon, A Guadaño-Ferraz
PloS one 2014
Tissue-Specific Inactivation of Type 2 Deiodinase Reveals Multilevel Control of Fatty Acid Oxidation by Thyroid Hormone in the Mouse
TL Fonseca, JP Werneck-De-Castro, M Castillo, BM Bocco, GW Fernandes, EA McAninch, DL Ignacio, CC Moises, AR Ferreira, B Gereben, AC Bianco
Diabetes 2014
NT-PGC-1  Activation Attenuates High-Fat Diet-Induced Obesity by Enhancing Brown Fat Thermogenesis and Adipose Tissue Oxidative Metabolism
HJ Jun, Y Joshi, Y Patil, RC Noland, JS Chang
Diabetes 2014
Adrenergic pathway activation enhances brown adipose tissue metabolism: A [18F]FDG PET/CT study in mice
MR Mirbolooki, SK Upadhyay, CC Constantinescu, ML Pan, J Mukherjee
Nuclear Medicine and Biology 2014
Regulation of body temperature and brown adipose tissue thermogenesis by bombesin receptor subtype-3
DM Lateef, G Abreu-Vieira, C Xiao, ML Reitman
American journal of physiology. Endocrinology and metabolism 2014
RNA-seq analysis of the rat placentation site reveals maternal obesity-associated changes in placental and offspring thyroid hormone signaling
J Saben, P Kang, Y Zhong, KM Thakali, H Gomez-Acevedo, SJ Borengasser, A Andres, TM Badger, K Shankar
Placenta 2014
Life Without the Iodothyronine Deiodinases
VA Galton, E Waard, AF Parlow, DL st Germain, A Hernandez
Endocrinology 2014
Selenoproteins: Molecular Pathways and Physiological Roles
VM Labunskyy, DL Hatfield, VN Gladyshev
Physiological reviews 2014
Presence of Brown Adipose Tissue in an Adolescent With Severe Primary Hypothyroidism
MS Kim, HH Hu, PC Aggabao, ME Geffner, V Gilsanz
The Journal of clinical endocrinology and metabolism 2014
American Thyroid Association Guide to Investigating Thyroid Hormone Economy and Action in Rodent and Cell Models
AC Bianco, G Anderson, D Forrest, VA Dr, B Gereben, BW Kim, PA Kopp, XH Liao, MJ Obregon, R Peeters, S Refetoff, D Sharlin, WS Simonides, RE Weiss, G Williams
Thyroid 2013
The role of thyroid hormone and brown adipose tissue in energy homoeostasis
AC Bianco, EA McAninch
The Lancet Diabetes & Endocrinology 2013
Thyroid Hormones and the Metabolic Syndrome
KA Iwen, E Schröder, G Brabant
European Thyroid Journal 2013
Targeted Deletion of Fibrinogen Like Protein 1 Reveals a Novel Role in Energy Substrate Utilization
V Demchev, G Malana, D Vangala, J Stoll, A Desai, HW Kang, Y Li, H Nayeb-Hashemi, M Niepel, DE Cohen, C Ukomadu
PloS one 2013
Brown and beige fat: development, function and therapeutic potential
M Harms, P Seale
Nature Medicine 2013
Assessment of brown adipose tissue function
S Virtue, A Vidal-Puig
Frontiers in physiology 2013
The deiodinases and the control of intracellular thyroid hormone signaling during cellular differentiation☆
M Dentice, A Marsili, AM Zavacki, PR Larsen, D Salvatore
Biochimica et Biophysica Acta 2013
Metal Ions in Life Sciences
S Kurokawa, MJ Berry
Metal ions in life sciences 2013
NAT8L (N-Acetyltransferase 8-Like) Accelerates Lipid Turnover and Increases Energy Expenditure in Brown Adipocytes
AR Pessentheiner, HJ Pelzmann, E Walenta, M Schweiger, LN Groschner, WF Graier, D Kolb, K Uno, T Miyazaki, A Nitta, D Rieder, A Prokesch, JG Bogner-Strauss
The Journal of biological chemistry 2013
Cardiac Expression of Human Type 2 Iodothyronine Deiodinase Increases Glucose Metabolism and Protects Against Doxorubicin-induced Cardiac Dysfunction in Male Mice
EG Hong, BW Kim, DY Jung, JH Kim, T Yu, WS da Silva, RH Friedline, SD Bianco, SP Seslar, H Wakimoto, CI Berul, KS Russell, KW Lee, PR Larsen, AC Bianco, JK Kim
Endocrinology 2013
Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling
RA Drigo, TL Fonseca, JP Werneck-de-Castro, AC Bianco
Biochimica et Biophysica Acta (BBA) - General Subjects 2012
 1 Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice
CB Ueta, GW Fernandes, LP Capelo, TL Fonseca, FD Maculan, CH Gouveia, PC Brum, MA Christoffolete, MS Aoki, CL Lancellotti, B Kim, AC Bianco, MO Ribeiro
Journal of Endocrinology 2012
Programming human pluripotent stem cells into white and brown adipocytes
T Ahfeldt, RT Schinzel, YK Lee, D Hendrickson, A Kaplan, DH Lum, R Camahort, F Xia, J Shay, EP Rhee, CB Clish, RC Deo, T Shen, FH Lau, A Cowley, G Mowrer, H Al-Siddiqi, M Nahrendorf, K Musunuru, RE Gerszten, JL Rinn, CA Cowan
Nature Cell Biology 2012
Thyroid Hormone Replacement Therapy: Three 'Simple' Questions, Complex Answers
AC Bianco, S Casula
European Thyroid Journal 2012
PPARγ activation attenuates cold-induced upregulation of thyroid status and brown adipose tissue PGC-1α and D2
WT Festuccia, PG Blanchard, TB Oliveira, J Magdalon, VA Paschoal, D Richard, Y Deshaies
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2012
Transient brown adipocyte-like cells derive from peripheral nerve progenitors in response to bone morphogenetic protein 2
EA Salisbury, ZW Lazard, EE Ubogu, AR Davis, EA Olmsted-Davis
Stem Cells Translational Medicine 2012
Dietary selenium and selenoprotein function.
Weeks BS, Hanna MS, Cooperstein D
Medical science monitor : international medical journal of experimental and clinical research 2012
Genetic Defect in Phospholipase Cδ1 Protects Mice From Obesity by Regulating Thermogenesis and Adipogenesis
M Hirata, M Suzuki, R Ishii, R Satow, T Uchida, T Kitazumi, T Sasaki, T Kitamura, H Yamaguchi, Y Nakamura, K Fukami
Diabetes 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Bioenergetic impact of tissue-specific regulation of iodothyronine deiodinases during nutritional imbalance
RL Araujo, DP Carvalho
Journal of Bioenergetics and Biomembranes 2011
The Implication of Brown Adipose Tissue for Humans
E Ravussin, JE Galgani
Annual Review of Nutrition 2011
The role of hypothalamic tri-iodothyronine availability in seasonal regulation of energy balance and body weight
M Murphy, FJ Ebling
Journal of Thyroid Research 2011
The Arrestin Domain-Containing 3 Protein Regulates Body Mass and Energy Expenditure
P Patwari, V Emilsson, EE Schadt, WA Chutkow, S Lee, A Marsili, Y Zhang, R Dobrin, DE Cohen, PR Larsen, AM Zavacki, LG Fong, SG Young, RT Lee
Cell Metabolism 2011
Recent progress in the study of brown adipose tissue
X Yao, S Shan, Y Zhang, H Ying
Cell & Bioscience 2011
Control of Brown Adipose Tissue Glucose and Lipid Metabolism by PPARγ
WT Festuccia, PG Blanchard, Y Deshaies
Frontiers in Endocrinology 2011
Minireview: Cracking the Metabolic Code for Thyroid Hormone Signaling
AC Bianco
Endocrinology 2011
Type-2 Iodothyronine 5′Deiodinase (D2) in Skeletal Muscle of C57Bl/6 Mice. II. Evidence for a Role of D2 in the Hypermetabolism of Thyroid Hormone Receptor α-Deficient Mice
W Ramadan, A Marsili, PR Larsen, AM Zavacki, JE Silva
Endocrinology 2011
Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure*
M Watanabe, Y Horai, SM Houten, K Morimoto, T Sugizaki, E Arita, C Mataki, H Sato, Y Tanigawara, K Schoonjans, H Itoh, J Auwerx
The Journal of biological chemistry 2011
Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure
BC de Jonghe, MR Hayes, R Banno, KP Skibicka, DJ Zimmer, KA Bowen, TM Leichner, AL Alhadeff, SE Kanoski, NE Cyr, EA Nillni, HJ Grill, KK Bence
American journal of physiology. Endocrinology and metabolism 2011
A Component of Retinal Light Adaptation Mediated by the Thyroid Hormone Cascade
DE Bedolla, V Torre
PloS one 2011
Physiological role and regulation of iodothyronine deiodinases: a 2011 update
A Marsili, AM Zavacki, JW Harney, PR Larsen
Journal of Endocrinological Investigation 2011
Type 2 deiodinase at the crossroads of thyroid hormone action
RA Drigo, AC Bianco
The International Journal of Biochemistry & Cell Biology 2011
Disruption of Thyroid Hormone Activation in Type 2 Deiodinase Knockout Mice Causes Obesity With Glucose Intolerance and Liver Steatosis Only at Thermoneutrality
M Castillo, JA Hall, M Correa-Medina, C Ueta, HW Kang, DE Cohen, AC Bianco
Diabetes 2011
Increased metabolic rate and insulin sensitivity in male mice lacking the carcino-embryonic antigen-related cell adhesion molecule 2
PR Patel, SK Ramakrishnan, MK Kaw, CK Raphael, S Ghosh, JS Marino, G Heinrich, SJ Lee, RE Bourey, JW Hill, DY Jung, DA Morgan, JK Kim, SK Rahmouni, SM Najjar
Diabetologia 2011
Mice with a Targeted Deletion of the Type 2 Deiodinase Are Insulin Resistant and Susceptible to Diet Induced Obesity
A Marsili, C Aguayo-Mazzucato, T Chen, A Kumar, M Chung, EP Lunsford, JW Harney, T Van-Tran, E Gianetti, W Ramadan, C Chou, S Bonner-Weir, PR Larsen, JE Silva, AM Zavacki, A Bartolomucci
PloS one 2011
The Nuclear Receptor Corepressor (NCoR) Controls Thyroid Hormone Sensitivity and the Set Point of the Hypothalamic-Pituitary-Thyroid Axis
I Astapova, KR Vella, P Ramadoss, KA Holtz, BA Rodwin, XH Liao, RE Weiss, MA Rosenberg, A Rosenzweig, AN Hollenberg
Molecular Endocrinology 2011
Physiological role and regulation of iodothyronine deiodinases: a 2011 update.
Marsili A, Zavacki AM, Harney JW, Larsen PR
Journal of Endocrinological Investigation 2011
Regulation of the hypothalamic Thyrotropin Releasing Hormone (TRH) neuron by neuronal and peripheral inputs
EA Nillni
Frontiers in Neuroendocrinology 2010
Impaired metabolic effects of a thyroid hormone receptor beta-selective agonist in a mouse model of diet-induced obesity
M Castillo, BC Freitas, ML Rosene, RA Drigo, R Grozovsky, RM Maciel, ME Patti, MO Ribeiro, AC Bianco
Thyroid : official journal of the American Thyroid Association 2010
New insights into thyroid hormone replacement therapy
BM Acosta, AC Bianco
F1000 medicine reports 2010
Food deprivation alters thermoregulatory responses to lipopolysaccharide by enhancing cryogenic inflammatory signaling via prostaglandin D2
CM Krall, X Yao, MA Hass, C Feleder, AA Steiner
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2010
Insulin Represses Transcription of the Thyroid Stimulating Hormone β-Subunit Gene through Increased Recruitment of Nuclear Factor I*
KK Kim, KS Park, SB Song, KE Kim
The Journal of biological chemistry 2010
Absence of Thyroid Hormone Activation during Development Underlies a Permanent Defect in Adaptive Thermogenesis
JA Hall, S Ribich, MA Christoffolete, G Simovic, M Correa-Medina, ME Patti, AC Bianco
Endocrinology 2010
Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity
H Sampath, MT Flowers, X Liu, CM Paton, R Sullivan, K Chu, M Zhao, JM Ntambi
The Journal of biological chemistry 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-beta isoform specific and required for adaptive thermogenesis
MO Ribeiro, SD Bianco, M Kaneshige, JJ Schultz, S Cheng, AC Bianco, GA Brent
Endocrinology 2009
The human selenoproteome: recent insights into functions and regulation
MA Reeves, PR Hoffmann
Cellular and Molecular Life Sciences 2009
Thyroid Hormone Activation in Vascular Smooth Muscle Cells Is Negatively Regulated by Glucocorticoid
N Toyoda, S Yasuzawa-Amano, E Nomura, A Yamauchi, K Nishimura, C Ukita, S Morimoto, A Kosaki, T Iwasaka, JW Harney, PR Larsen, M Nishikawa
Thyroid 2009
Endocrine disrupters as obesogens
F Grün, B Blumberg
Molecular and Cellular Endocrinology 2009
Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue
Y Cheng, Q Meng, C Wang, H Li, Z Huang, S Chen, F Xiao, F Guo
Diabetes 2009
Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue
HW Kang, S Ribich, BW Kim, SJ Hagen, AC Bianco, DE Cohen
Journal of lipid research 2009
Triumphs of the Thyroid Despite Lesser Conversion
JA Hall, AC Bianco
Endocrinology 2009
Minireview: The Case for Obesogens
F Grün, B Blumberg
Molecular Endocrinology 2009
Life without Thyroxine to 3,5,3′-Triiodothyronine Conversion: Studies in Mice Devoid of the 5′-Deiodinases
VA Galton, MJ Schneider, AS Clark, DL Germain
Endocrinology 2009
Defining the Roles of the Iodothyronine Deiodinases: Current Concepts and Challenges
DL Germain, VA Galton, A Hernandez
Endocrinology 2009
Hypoxia-inducible factor induces local thyroid hormone inactivation in hypoxic-ischemic disease
1. Warner S. Simonides 2. Michelle A. Mulcahey 3. Everaldo M. Redout 4. Alice Muller 5. Marian J. Zuidwijk 6. Theo J. Visser 7. Frank W.J.S. Wassen 8. Alessandra Crescenzi 9. Wagner S. da-Silva 10. John Harney 11. Felix B. Engel 12. Maria-Jesús Obregon 13. P. Reed Larsen 14. Antonio C. Bianco 15. Stephen A. Huang
Journal of Clinical Investigation 2008
Reawakened interest in type III iodothyronine deiodinase in critical illness and injury
SA Huang, AC Bianco
Nature Clinical Practice Endocrinology & Metabolism 2008
Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling1
B Gereben, AM Zavacki, S Ribich, BW Kim, SA Huang, WS Simonides, A Zeöld, AC Bianco
Endocrine reviews 2008
Type 2 Deiodinase Expression Is Induced by Peroxisomal Proliferator-Activated Receptor-γ Agonists in Skeletal Myocytes
R Grozovsky, S Ribich, ML Rosene, MA Mulcahey, SA Huang, ME Patti, AC Bianco, BW Kim
Endocrinology 2008
Cardiomyocyte-specific inactivation of thyroid hormone in pathologic ventricular hypertrophy: an adaptative response or part of the problem?
CJ Pol, A Muller, WS Simonides
Heart Failure Reviews 2008
The brown adipocyte differentiation pathway in birds: an evolutionary road not taken
NV Mezentseva, JS Kumaratilake, SA Newman
BMC Biology 2008
Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis
M Angers, M Uldry, D Kong, JM Gimble, AM Jetten
Biochemical Journal 2008
Negative feedback regulation of hypophysiotropic thyrotropin-releasing hormone (TRH) synthesizing neurons: role of neuronal afferents and type 2 deiodinase
C Fekete, RM Lechan
Frontiers in Neuroendocrinology 2007
PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis
J Sonoda, IR Mehl, LW Chong, RR Nofsinger, RM Evans
Proceedings of the National Academy of Sciences 2007
Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis
JA Villena, MB Hock, WY Chang, JE Barcas, V Giguère, A Kralli
Proceedings of the National Academy of Sciences 2007
Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure
N Dali-Youcef, C Mataki, A Coste, N Messaddeq, S Giroud, S Blanc, C Koehl, MF Champy, P Chambon, L Fajas, D Metzger, K Schoonjans, J Auwerx
Proceedings of the National Academy of Sciences 2007
Selenoprotein expression is essential in endothelial cell development and cardiac muscle function
RK Shrimali, JA Weaver, GF Miller, MF Starost, BA Carlson, SV Novoselov, E Kumaraswamy, VN Gladyshev, DL Hatfield
Neuromuscular Disorders 2007
Deiodinases: Implications of the local control of thyroid hormone action
Antonio C. Bianco and Brian W. Kim
Journal of Clinical Investigation 2006
Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase
L Ng, RJ Goodyear, CA Woods, MJ Schneider, E Diamond, GP Richardson, MW Kelley, DL st Germain, VA Galton, D Forrest
Proceedings of the National Academy of Sciences 2004
Deubiquitination of type 2 iodothyronine deiodinase by pVHL-interacting deubiquitinating enzymes regulates thyroid hormone activation
Cyntia Curcio-Morelli, Ann Marie Zavacki, Marcelo Christofollete, Balazs Gereben, Beatriz C.G. de Freitas, John W. Harney, Zaibo Li, Guan Wu and Antonio C. Bianco
Journal of Clinical Investigation 2003

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