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Citations to this article

Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension.
B Hocher, … , W D Schleuning, F Theuring
B Hocher, … , W D Schleuning, F Theuring
Published March 15, 1997
Citation Information: J Clin Invest. 1997;99(6):1380-1389. https://doi.org/10.1172/JCI119297.
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Research Article Article has an altmetric score of 3

Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension.

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Abstract

The human endothelin-1 (ET-1) gene under the control of its natural promoter was transferred into the germline of mice. The transgene was expressed predominantly in the brain, lung, and kidney. Transgene expression was associated with a pathological phenotype manifested by signs such as age-dependent development of renal cysts, interstitial fibrosis of the kidneys, and glomerulosclerosis leading to a progressive decrease in glomerular filtration rate. This pathology developed in spite of only slightly elevated plasma and tissue ET-1 concentrations. Blood pressure was not affected even after the development of an impaired glomerular filtration rate. Therefore, these transgenic lines provide a new blood pressure-independent animal model of ET-1-induced renal pathology leading to renal fibrosis and fatal kidney disease.

Authors

B Hocher, C Thöne-Reineke, P Rohmeiss, F Schmager, T Slowinski, V Burst, F Siegmund, T Quertermous, C Bauer, H H Neumayer, W D Schleuning, F Theuring

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Citations to this article in year 2014 (10)

Title and authors Publication Year
Animal models of systemic sclerosis: their utility and limitations
C Artlett
Open Access Rheumatology : Research and Reviews 2014
Endothelin and endothelin antagonists in chronic kidney disease
DE Kohan, M Barton
Kidney International 2014
Obesity and heterozygous endothelial overexpression of prepro-endothelin-1 modulate responsiveness of mouse main and segmental renal arteries to vasoconstrictor agents
O Baretella, SK Chung, M Barton, A Xu, PM Vanhoutte
Life Sciences 2014
End O' The Line Revisited: Moving on from nitric oxide to CGRP
JG de Mey, PM Vanhoutte
Life Sciences 2014
Endothelin antagonism for patients with chronic kidney disease: still a hope for the future
MP Schneider, JF Mann
Nephrology Dialysis Transplantation 2014
Endothelin receptor antagonists in clinical research — Lessons learned from preclinical and clinical kidney studies
C Reichetzeder, O Tsuprykov, B Hocher
Life Sciences 2014
Association of endothelin-1 gene polymorphisms with the clinical phenotype in primary nephrotic syndrome of children
F Yang, X Lai, L Deng, X Liu, J Li, S Zeng, C Zhang, CF Hocher, B Hocher
Life Sciences 2014
Manual of Hypertension of the European Society of Hypertension, Second Edition
H Haller
Manual of Hypertension of the European Society of Hypertension, Second Edition 2014
Renoprotective effects of the direct renin inhibitor aliskiren on gentamicin-induced nephrotoxicity in rats
EH Bae, IJ Kim, SY Joo, EY Kim, JS Choi, CS Kim, SK Ma, JU Lee, SW Kim
Journal of Renin-Angiotensin-Aldosterone System 2014
Current state of endothelin receptor antagonism in hypertension and pulmonary hypertension
K Miyagawa, N Emoto
Therapeutic advances in cardiovascular disease 2014

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