Citations to this article

Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension.
B Hocher, … , W D Schleuning, F Theuring
B Hocher, … , W D Schleuning, F Theuring
Published March 15, 1997
Citation Information: J Clin Invest. 1997;99(6):1380-1389. https://doi.org/10.1172/JCI119297.
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Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension.

Abstract

The human endothelin-1 (ET-1) gene under the control of its natural promoter was transferred into the germline of mice. The transgene was expressed predominantly in the brain, lung, and kidney. Transgene expression was associated with a pathological phenotype manifested by signs such as age-dependent development of renal cysts, interstitial fibrosis of the kidneys, and glomerulosclerosis leading to a progressive decrease in glomerular filtration rate. This pathology developed in spite of only slightly elevated plasma and tissue ET-1 concentrations. Blood pressure was not affected even after the development of an impaired glomerular filtration rate. Therefore, these transgenic lines provide a new blood pressure-independent animal model of ET-1-induced renal pathology leading to renal fibrosis and fatal kidney disease.

Authors

B Hocher, C Thöne-Reineke, P Rohmeiss, F Schmager, T Slowinski, V Burst, F Siegmund, T Quertermous, C Bauer, H H Neumayer, W D Schleuning, F Theuring

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Citations to this article in year 2008 (13)

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Lack of iNOS Impairs Endothelial Function in Endothelin-1 Transgenic Mice
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