Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Pancreatic Cancer (Jul 2025)
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension.
B Hocher, … , W D Schleuning, F Theuring
B Hocher, … , W D Schleuning, F Theuring
Published March 15, 1997
Citation Information: J Clin Invest. 1997;99(6):1380-1389. https://doi.org/10.1172/JCI119297.
View: Text | PDF
Research Article Article has an altmetric score of 3

Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension.

  • Text
  • PDF
Abstract

The human endothelin-1 (ET-1) gene under the control of its natural promoter was transferred into the germline of mice. The transgene was expressed predominantly in the brain, lung, and kidney. Transgene expression was associated with a pathological phenotype manifested by signs such as age-dependent development of renal cysts, interstitial fibrosis of the kidneys, and glomerulosclerosis leading to a progressive decrease in glomerular filtration rate. This pathology developed in spite of only slightly elevated plasma and tissue ET-1 concentrations. Blood pressure was not affected even after the development of an impaired glomerular filtration rate. Therefore, these transgenic lines provide a new blood pressure-independent animal model of ET-1-induced renal pathology leading to renal fibrosis and fatal kidney disease.

Authors

B Hocher, C Thöne-Reineke, P Rohmeiss, F Schmager, T Slowinski, V Burst, F Siegmund, T Quertermous, C Bauer, H H Neumayer, W D Schleuning, F Theuring

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1995 Total
Citations: 4 3 1 4 5 9 6 6 10 13 11 10 9 8 8 9 13 13 11 13 7 13 19 11 19 19 13 17 2 1 287
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2013 (9)

Title and authors Publication Year
Chronic kidney disease: a new look at pathogenetic mechanisms and treatment options
D Noone, C Licht
Pediatric Nephrology 2013
ET-1 actions in the kidney: evidence for sex differences
W Kittikulsuth, JC Sullivan, DM Pollock
British Journal of Pharmacology 2013
Emerging drugs for managing kidney disease in patients with diabetes
MC Thomas
Expert Opinion on Emerging Drugs 2013
The profibrotic role of endothelin-1: Is the door still open for the treatment of fibrotic diseases?
F Rodríguez-Pascual, O Busnadiego, J González-Santamaría
Life Sciences 2013
Chinese herbal medicine Shenqi Detoxification Granule inhibits fibrosis in adenine induced chronic renal failure rats
Min Peng, Pingping Cai, Hongbo Ma, Hongyan Meng, Yuan Xu, Xiaoyi Zhang, Guomin Si
African Journal of Traditional, Complementary, and Alternative Medicines 2013
Adipokines as a link between obesity and chronic kidney disease
JF Briffa, AJ McAinch, P Poronnik, DH Hryciw
American journal of physiology. Renal physiology 2013
Does endoplasmic reticulum stress mediate endothelin-1-induced renal inflammation?
CD Miguel, JS Pollock
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2013
Cerebral Blood Flow, Metabolism, and Head Trauma
CW Kreipke, JA Rafols
2013
The Effects of Melatonin and Endothelin-A Receptor Antagonist BQ-123 in Exposed to Smoke in Rat Renal Tissue
H Erdogan, F Ekici, H Aslan, B Ozyurt, F Erdogan, O Atis
2013

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 2 patents
76 readers on Mendeley
See more details