JCI - Citations to Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension.

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Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension.

B Hocher, … , W D Schleuning, F Theuring

B Hocher, … , W D Schleuning, F Theuring

Published March 15, 1997
Citation Information: J Clin Invest. 1997;99(6):1380-1389. https://doi.org/10.1172/JCI119297.

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Oxidative Stress in Kidney Injury and Hypertension Arendshorst WJ, Vendrov AE, Kumar N, Ganesh SK, Madamanchi NR	Antioxidants	2024
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Animal Models of Systemic Sclerosis: Using Nailfold Capillaroscopy as a Potential Tool to Evaluate Microcirculation and Microangiopathy: A Narrative Review Mandujano A, Golubov M	Life Sciences	2022
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Association of Endothelin-1 rs5370 G>T gene polymorphism with the risk of nephrotic syndrome in children M Hashemi, S Sadeghi-Bojd, S Aryanezhad, M Rezaei	Journal of Nephropathology	2016
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Targeted activation of endothelin-1 exacerbates hypoxia-induced pulmonary hypertension MG Satwiko, K Ikeda, K Nakayama, K Yagi, B Hocher, K Hirata, N Emoto	Biochemical and Biophysical Research Communications	2015
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Association of endothelin-1 gene polymorphisms with the clinical phenotype in primary nephrotic syndrome of children F Yang, X Lai, L Deng, X Liu, J Li, S Zeng, C Zhang, CF Hocher, B Hocher	Life Sciences	2014
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Endothelin in hypertension : an update Y Rautureau, EL Schiffrin	Current Opinion in Nephrology & Hypertension	2012
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Autoantibody-Mediated IL-6–Dependent Endothelin-1 Elevation Underlies Pathogenesis in a Mouse Model of Preeclampsia CC Zhou, RA Irani, Y Dai, SC Blackwell, MJ Hicks, SM Ramin, RE Kellems, Y Xia	Journal of immunology (Baltimore, Md. : 1950)	2011
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Translational Vascular Medicine D Abraham, C Handler, M Dashwood, G Coghlan		2011
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Therapeutic potential of endothelin receptor antagonists for chronic proteinuric renal disease in humans M Barton	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease	2010
Plasma C-terminal pro-endothelin-1 is associated with target-organ damage in African Americans with hypertension A Habib, MA Al-Omari, M Khaleghi, NG Morgenthaler, J Struck, A Bergmann, TH Mosley, ST Turner, IJ Kullo	American Journal of Hypertension	2010
Endothelin-1 Increases Collagen Accumulation in Renal Mesangial Cells by Stimulating a Chemokine and Cytokine Autocrine Signaling Loop MS Simonson, F Ismail-Beigi	The Journal of biological chemistry	2010
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Endothelin-1 Increases Glomerular Permeability and Inflammation Independent of Blood Pressure in the Rat MA Saleh, EI Boesen, JS Pollock, VJ Savin, DM Pollock	Hypertension	2010
Molecular Pathology of Liver Diseases SP Monga		2010
Pathophysiology of the endothelin system - lessons from genetically manipulated animal models K von Websky, S Heiden, T Pfab, B Hocher	European Journal of Medical Research	2009
The endothelin receptor antagonist avosentan ameliorates nephropathy and atherosclerosis in diabetic apolipoprotein E knockout mice. Watson AM, Li J, Schumacher C, de Gasparo M, Feng B, Thomas MC, Allen TJ, Cooper ME, Jandeleit-Dahm KA	Diabetologia	2009
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Endothelin receptor selectivity in chronic kidney disease: rationale and review of recent evidence W Neuhofer, D Pittrow	European Journal of Clinical Investigation	2009
Endothelin receptor selectivity in chronic renal failure L Longaretti, A Benigni	European Journal of Clinical Investigation	2009
Endothelin receptor antagonists as antihypertensives: the next frontier BJ Epstein, S Anderson	Expert Review of Cardiovascular Therapy	2009
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Effect of nicorandil on proteinuria in well controlled hypertensive patients TM Lee, NC Chang	Journal of Hypertension	2009
The endothelin receptor antagonist avosentan ameliorates nephropathy and atherosclerosis in diabetic apolipoprotein E knockout mice AM Watson, J Li, C Schumacher, M Gasparo, B Feng, MC Thomas, TJ Allen, ME Cooper, KA Jandeleit-Dahm	Diabetologia	2009
Renal phenotype of Et-1 transgenic mice is modulated by androgens P Kalk, C Thöne-Reineke, A Schwarz, M Godes, C Bauer, T Pfab, B Hocher	European Journal of Medical Research	2009
Deficiency in Six2 during prenatal development is associated with reduced nephron number, chronic renal failure, and hypertension in Br /+ adult mice B Fogelgren, S Yang, IC Sharp, OJ Huckstep, W Ma, SJ Somponpun, EC Carlson, CF Uyehara, S Lozanoff	American journal of physiology. Renal physiology	2009
Urinary endothelin-1 in chronic kidney disease and as a marker of disease activity in lupus nephritis N Dhaun, P Lilitkarntakul, IM MacIntyre, E Muilwijk, NR Johnston, DC Kluth, DJ Webb, J Goddard	American journal of physiology. Renal physiology	2009
Advances in Vascular Medicine D Abraham, H Clive, M Dashwood, G Coghlan	Advances in Vascular Medicine	2009
Endothelin-1 and F2-isoprostane relate to and predict renal dysfunction in hypertensive patients S Cottone, G Mule, M Guarneri, A Palermo, MC Lorito, R Riccobene, R Arsena, F Vaccaro, A Vadala, E Nardi, P Cusimano, G Cerasola	Nephrology Dialysis Transplantation	2008
Lack of iNOS Impairs Endothelial Function in Endothelin-1 Transgenic Mice T Quaschning, F Voss, S Herzfeld, K Relle, P Kalk, M Godes, T Pfab, A Kraemer-Guth, AW Bonz, F Theuring, J Galle, B Hocher	Kidney and Blood Pressure Research	2008
Pulmonary fibrosis inl-NAME-treated mice is dependent on an activated endothelin systemThis article is one of a selection of papers published in the special issue (part 2 of 2) on Forefronts in Endothelin P Kalk, A Mach, C Thone-Reineke, M Godes, S Heiden, Y Sharkovska, K Websky, K Relle, B Hocher	Canadian Journal of Physiology and Pharmacology	2008
Reversal of proteinuric renal disease and the emerging role of endothelin M Barton	Nature Clinical Practice Nephrology	2008
Restoration of endothelin-1-induced impairment in endothelium-dependent relaxation by interleukin-10 in murine aortic rings SM Zemse, RH Hilgers, GB Simkins, RD Rudic, RC Webb	Canadian Journal of Physiology and Pharmacology	2008
Role of angiotensin II, endothelin-1 and L-type calcium channel in the development of glomerular, tubulointerstitial and perivascular fibrosis TM Seccia, C Maniero, AS Belloni, D Guidolin, P Poulose, AC Pessina, GP Rossi	Journal of Hypertension	2008
Impact of endothelin-1 Lys198Asn polymorphism on coronary artery disease and endorgan damage in hypertensives AF Popov, EG Schulz, J Hinz, JD Schmitto, R Seipelt, MJ Koziolek, A Rosenberger, FA Schoendube, GA Müller	Coronary Artery Disease	2008
Endothelin: 20 years from discovery to therapyThis article is one of a selection of papers published in the special issue (part 2 of 2) on Forefronts in Endothelin M Barton, M Yanagisawa	Canadian Journal of Physiology and Pharmacology	2008
Additional lack of iNOS attenuates diastolic dysfunction in aged ET-1 transgenic miceThis article is one of a selection of papers published in the special issue (part 1 of 2) on Forefronts in Endothelin P Kalk, D Westermann, S Herzfeld, K Relle, T Pfab, C Bauer, C Tschöpe, JP Stasch, B Hocher	Canadian Journal of Physiology and Pharmacology	2008
Manual of Hypertension of The European Society of Hypertension: other humoral-endocrine factors M Burnier	Manual of Hypertension of The European Society of Hypertension: other humoral-endocrine factors	2008
Vascular Complications in Human Disease D Abraham, M Dashwood, C Handler, G Coghlan		2008
Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist M Iglarz, C Binkert, K Morrison, W Fischli, J Gatfield, A Treiber, T Weller, MH Bolli, C Boss, S Buchmann, B Capeleto, P Hess, C Qiu, M Clozel	The Journal of pharmacology and experimental therapeutics	2008
Régression de la fibrose rénale : ce que nous apprennent les modèles animaux JC Dussaule, C Chatziantoniou	Bulletin de l'Académie nationale de médecine	2008
Reply: S Zanlungo, JF Miquel, F Nervi	Hepatology	2007
Endothelin-1 promotes cell survival in renal cell carcinoma through the ETA receptor BR Pflug, H Zheng, MS Udan, JM D'Antonio, FF Marshall, JD Brooks, JB Nelson	Cancer Letters	2007
Fibrosis in connective tissue disease: the role of the myofibroblast and fibroblast-epithelial cell interactions T Krieg, D Abraham, R Lafyatis	Arthritis Research & Therapy	2007
High-protein diet and high-grade proteinuria aggravate the progression of chronic renal failure in rats L He	Journal of Chinese Integrative Medicine	2007
Reversal of renal disease: is it enough to inhibit the action of angiotensin II? JC Dussaule, C Chatziantoniou	Cell Death and Differentiation	2007
Endothelin-1 Induces NF-κB via Two Independent Pathways in Human Renal Tubular Epithelial Cells M Gerstung, T Roth, HP Dienes, C Licht, JW Fries	American Journal of Nephrology	2007
Potential Pharmacological Interventions in Polycystic Kidney Disease A Masoumi, B Reed-Gitomer, C Kelleher, RW Schrier	Drugs	2007
Endothéline-1 et crise rénale sclérodermique B Terrier, L Guillevin, L Mouthon	La Revue de Médecine Interne	2007
Endothelin-1 Induces NF-κB via Two Independent Pathways in Human Renal Tubular Epithelial Cells M Gerstung, T Roth, HP Dienes, C Licht, JW Fries	American Journal of Nephrology	2007
Endothelin-1 Activates MAPKs and Modulates Cell Cycle Proteins in OKP Cells TS Chu, MS Wu, KD Wu, BS Hsieh	Journal of the Formosan Medical Association	2007
Cell-type specific interaction of endothelin and the nitric oxide system: pattern of prepro-ET-1 expression in kidneys of l -NAME treated prepro-ET-1 promoter- lacZ -transgenic mice: Cell-type specific interaction of the ET and NO systems T Slowinski, P Kalk, M Christian, F Schmager, K Relle, M Godes, H Funke-Kaiser, HH Neumayer, C Bauer, F Theuring, B Hocher	The Journal of Physiology	2007
Hypertension, kidney, and transgenics: a fresh perspective LJ Mullins, MA Bailey, JJ Mullins	Physiological reviews	2006
Insulin and Endothelin: An Interplay Contributing to Hypertension Development? PA Sarafidis, GL Bakris	The Journal of clinical endocrinology and metabolism	2006
Endothelin-1 enhances fibrogenic gene expression, but does not promote DNA synthesis or apoptosis in hepatic stellate cells M Koda, M Bauer, A Krebs, EG Hahn, D Schuppan, Y Murawaki	Comparative hepatology	2006
Role of endothelin and endothelin receptor antagonists in renal disease W Neuhofer, D Pittrow	European Journal of Clinical Investigation	2006
Cardiovascular endothelins: Essential regulators of cardiovascular homeostasis F Brunner, C Brás-Silva, AS Cerdeira, AF Leite-Moreira	Pharmacology & Therapeutics	2006
Increased endothelin-1 levels of BAL fluid in patients with pulmonary sarcoidosis K TERASHITA, S KATO, M SATA, S INOUE, H NAKAMURA, H TOMOIKE	Respirology	2006
Association between endothelin-1 and collagen deposition in db/db diabetic mouse kidneys R Mishra, SN Emancipator, TS Kern, MS Simonson	Biochemical and Biophysical Research Communications	2006
Influence of Endothelin-1 Gene Polymorphisms on the Progression of Autosomal Dominant Polycystic Kidney Disease J Reiterová, M Merta, J &Scaron;tekrová, Z &Ccaron;abartová, R Cibulka, D Maixnerová, R Ry&scaron;avá, Z &Rcaron;íhová, V Tesar, J Motá&ncaron;	Kidney and Blood Pressure Research	2006
Effects of renal failure on drug transport and metabolism H Sun, L Frassetto, LZ Benet	Pharmacology & Therapeutics	2006
The Influence of the Endothelin-Converting Enzyme-1 Gene Polymorphism on the Progression of Autosomal Dominant Polycystic Kidney Disease J Reiterová, M Merta, J Stekrová, V Tesar, D Kmentová, Z Ríhová, R Ryšavá, O Viklický	Renal Failure	2006
Handbook of Models for Human Aging JP Janssens	Handbook of Models for Human Aging	2006
High-protein nutrition during pregnancy and lactation programs blood pressure, food efficiency, and body weight of the offspring in a sex-dependent manner C Thone-Reineke, P Kalk, M Dorn, S Klaus, K Simon, T Pfab, M Godes, P Persson, T Unger, B Hocher	American Journal of Physiology - Regulatory, Integrative and Comparative Physiology	2006
Circulating levels of endothelin-1 in a homogenous Gulf Arab population with untreated essential hypertension Enyioma Obineche, Abdishakur M Abdulle, Awais M Bokhari, Javed Y Yasin, Michael P T Gillett	Annals of Saudi medicine	2006
HEPATIC FIBROSIS: Molecular Mechanisms and Drug Targets S Lotersztajn, B Julien, F Teixeira-Clerc, P Grenard, A Mallat	Annual Review of Pharmacology and Toxicology	2005
The role of endothelin-1 in myocarditis and inflammatory cardiomyopathy: old lessons and new insights LL Yang, S Arab, P Liu, DJ Stewart, M Husain	Canadian Journal of Physiology and Pharmacology	2005
Carbon monoxide, but not endothelin-1, plays a major role for the hepatic microcirculation in a murine model of early systemic inflammation C Wunder, RW Brock, S Frantz, W G??ttsch, H Morawietz, N Roewer, O Eichelbr??nner	Critical Care Medicine	2005
Systemic cardiovascular disease in uremic rats induced by 1,25(OH)2D3 D Haffner, B Hocher, D Müller, K Simon, K König, CM Richter, B Eggert, J Schwarz, M Godes, R Nissel, U Querfeld	Journal of Hypertension	2005
Angiotensin II sensitivity of afferent glomerular arterioles in endothelin-1 transgenic mice A Patzak, J Bontscho, E Lai, E Kupsch, A Skalweit, CM Richter, M Zimmermann, C Thone-Reineke, O Joehren, M Godes, A Steege, B Hocher	Nephrology Dialysis Transplantation	2005
Insights into the mechanisms of renal fibrosis: is it possible to achieve regression? C Chatziantoniou, JC Dussaule	American journal of physiology. Renal physiology	2005
Role of endothelin in fibrosis and anti‐fibrotic potential of bosentan M Clozel, H Salloukh	Annals of Medicine	2005
From Hyperglycemia to Diabetic Kidney Disease: The Role of Metabolic, Hemodynamic, Intracellular Factors and Growth Factors/Cytokines BF Schrijvers, AS Vriese, A Flyvbjerg	Endocrine reviews	2004
Progression and regression in renal vascular and glomerular fibrosis C Chatziantoniou, JJ Boffa, PL Tharaux, M Flamant, P Ronco, JC Dussaule	International Journal of Experimental Pathology	2004
Plasma endothelin-1 level is related to renal function and smoking status but not to blood pressure Y Hirai, H Adachi, Y Fujiura, A Hiratsuka, M Enomoto, T Imaizumi	Journal of Hypertension	2004
The expression and activity of renal nitric oxide synthase and circulating nitric oxide in polycystic kidney disease rats D Wang, O Braendstrup, S Larsen, T Horn, S Strandgaard	APMIS	2004
The potential of endothelin antagonism as a therapeutic approach A Benigni, N Perico, G Remuzzi	Expert Opinion on Investigational Drugs	2004
The endothelin system in Morris hepatoma-7777: an endothelin receptor antagonist inhibits growth in vitro and in vivo T Pfab, G Stoltenburg-Didinger, C Trautner, M Godes, C Bauer, B Hocher	British Journal of Pharmacology	2004
Endothelin receptor antagonist TAK-044 arrests and reverses the development of carbon tetrachloride induced cirrhosis in rats C Thirunavukkarasu, Y Yang, VM Subbotin, SA Harvey, J Fung, CR Gandhi	Gut	2004
Mild developmental delay in terminal chromosome 6p deletion KM Chen, AM Cherry, JS Hahn, GM Enns	American Journal of Medical Genetics	2004
Blockade of Endothelin Receptors Attenuates End-Organ Damage in Homozygous Hypertensive Ren-2 Transgenic Rats P Dvo&rcaron;ák, HJ Kramer, A Bäcker, J Malý, L Kopkan, I Van&ecaron;&ccaron;ková, Z Vernerová, M Opo&ccaron;enský, V Tesa&rcaron;, M Bader, D Ganten, J Janda, L &Ccaron;ervenka	Kidney and Blood Pressure Research	2004
Chronic cyclooxygenase-2 inhibition does not alter blood pressure and kidney function in renovascular hypertensive rats: CM Richter, M Godes, C Wagner, C Maser-Gluth, S Herzfeld, M Dorn, F Priem, T Slowinski, C Bauer, W Schneider, HH Neumayer, A Kurtz, B Hocher	Journal of Hypertension	2004
In-vivo interaction of nitric oxide and endothelin: B Hocher, A Schwarz, T Slowinski, S Bachmann, J Pfeilschifter, HH Neumayer, C Bauer	Journal of Hypertension	2004
Transgenic Models in Pharmacology S Offermanns, L Hein		2004
Transgenic Mice Over-expressing Endothelin-1 in Testis Transactivated by a Cre/loxP System Showed Decreased Testicular Capillary Blood Flow AC Lo, MK Fung, CL Au, TS Chan, B Sauer, SS Chung, SK Chung	Transgenic Research	2004
Prevention of cultured rat stellate cell transformation and endothelin-B receptor upregulation by retinoic acid X Chi, K Anselmi, S Watkins, CR Gandhi	British Journal of Pharmacology	2003
Endothelin-1 in chronic renal failure and hypertension R Larivière, M Lebel	Canadian Journal of Physiology and Pharmacology	2003
Enrasentan, an Antagonist of Endothelin Receptors A Cosenzi	Cardiovascular Drug Reviews	2003
Influence of acute selective endothelin-receptor-A blockade on renal hemodynamics in a rat model of chronic allograft rejection T Knoll, J Oltersdorf, U Gottmann, M Schaub, MS Michel, M Kirchengast, FJ Woude, P Rohmeiss, C Braun, T Knoll, MS Michel	Transplant International	2003
Combined ETA/ETB receptor blockade of human peritoneal mesothelial cells inhibits collagen I RNA synthesis S Morgera, J Schlenstedt, P Hambach, M Giessing, S Deger, B Hocher, HH Neumayer	Kidney International	2003
Role of endothelins in animal models of hypertension: focus on cardiovascular protection P Moreau, EL Schiffrin	Canadian Journal of Physiology and Pharmacology	2003
Cux-1 transgenic mice develop glomerulosclerosis and interstitial fibrosis JG Brantley, M Sharma, NI Alcalay, GB Heuvel	Kidney International	2003
Renal damage is not improved by blockade of endothelin receptors in primary renin-dependent hypertension L Rothermund, P Kossmehl, HH Neumayer, M Paul, R Kreutz	Journal of Hypertension	2003
Endothelin protein expression as a significant prognostic factor in oesophageal squamous cell carcinoma Y Ishibashi, N Hanyu, K Nakada, Y Suzuki, T Yamamoto, T Takahashi, N Kawasaki, M Kawakami, M Matsushima, M Urashima	European Journal of Cancer	2003
Management of Diabetic Nephropathy B Schrijvers, AD Vriese, A Flyvbjerg	Management of Diabetic Nephropathy	2003
Nephroprotective Effect of Bosentan in Diabetic Rats: A Cosenzi, E Bernobich, R Trevisan, N Milutinovic, A Borri, G Bellini	Journal of Cardiovascular Pharmacology	2003
ACE inhibition increases expression of the ET B receptor in kidneys of mice with unilateral obstruction K Moridaira, J Morrissey, M Fitzgerald, G Guo, R McCracken, T Tolley, S Klahr	American journal of physiology. Renal physiology	2003
Gene expression profile of endothelin-1-induced growth in glomerular mesangial cells R Mishra, P Leahy, MS Simonson	American journal of physiology. Cell physiology	2003
Inflammation and Cardiac Diseases GZ Feuerstein, P Libby, DL Mann		2003
Endothelin A Receptor Blockade and Endothelin B Receptor Blockade Improve Hypokalemic Nephropathy by Different Mechanisms S Suga, N Yasui, F Yoshihara, T Horio, Y Kawano, K Kangawa, RJ Johnson	Journal of the American Society of Nephrology : JASN	2003
Aging of Cells in and Outside the Body SC Kaul, R Wadhwa		2003
Nitric Oxide Inhibits Stretch-Induced MAPK Activation in Mesangial Cells Through RhoA Inactivation JC Krepinsky, AJ Ingram, D Tang, D Wu, L Liu, JW Scholey	Journal of the American Society of Nephrology : JASN	2003
Role of the Endothelin-1 Gene Locus for Renal Impairment in the General Nondiabetic Population SJ Pinto-Sietsma, SM Herrmann, K Schmidt-Petersen, T Niu, HL Hillege, WM Janssen, D de Zeeuw, P de Jong, R Kreutz	Journal of the American Society of Nephrology : JASN	2003
ETA Receptor Blockade Induces Tubular Cell Proliferation and Cyst Growth in Rats with Polycystic Kidney Disease B Hocher, P Kalk, T Slowinski, M Godes, A Mach, S Herzfeld, D Wiesner, PC Arck, HH Neumayer, B Nafz	Journal of the American Society of Nephrology : JASN	2003
Endothelin Antagonism with Bosentan: Current Status and Future Perspectives K Ono, A Matsumori	Cardiovascular Drug Reviews	2002
Effects of VasoCare™ therapy on the initiation and progression of atherosclerosis S Babaei, DJ Stewart, P Picard, JC Monge	Atherosclerosis	2002
Antibody-induced albuminuria and accelerated focal glomerulosclerosis in the Thy-1.1 transgenic mouse KJ Assmann, JP van Son, HB Dïjkman, S Mentzel, JF Wetzels	Kidney International	2002
Endothelin-1 is a potent stimulator of α1β1 integrin-mediated collagen matrix remodeling by rat mesangial cells A Kitamura, S Kagami, M Urushihara, S Kondo, M Yoshizumi, T Tamaki, Y Kuroda	Biochemical and Biophysical Research Communications	2002
Endothelin A Receptor Blockade Decreases Expression of Growth Factors and Collagen and Improves Matrix Metalloproteinase-2 Activity in Kidneys from Stroke-Prone Spontaneously Hypertensive Rats RC Tostes, RM Touyz, G He, F Ammarguellat, EL Schiffrin	Journal of Cardiovascular Pharmacology	2002
Accelerated reversal of carbon tetrachloride-induced cirrhosis in rats by the endothelin receptor antagonist TAK-044 K Anselmi, VM Subbotin, E Nemoto, CR Gandhi	Journal of Gastroenterology and Hepatology	2002
Endothelin, nephropathy, and blood pressure FC Luft	Journal of Molecular Medicine	2002
Modulation of the β-adrenergic receptor system of vascular smooth muscle cells in vitro and in vivo by chronically elevated endothelin-1 levels BR Brehm, SC Wolf, J Freudenberg, F Friedmann, H Heinle, K Schulze-Osthoff	Biochemical Pharmacology	2002
Effect of Pravastatin on Proteinuria in Patients With Well-Controlled Hypertension TM Lee, SF Su, CH Tsai	Hypertension	2002
Erythropoietin‐induced excessive erythrocytosis activates the tissue endothelin system in mice T Quaschning, F Ruschitzka, T Stallmach, S Shaw, H Morawietz, W Goettsch, M Hermann, T Slowinski, F Theuring, B Hocher, TF Lüscher, M Gassmann	The FASEB Journal	2002
Epidermal growth factor receptor transactivation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice M Flamant, PL Tharaux, S Placier, D Henrion, T Coffman, C Chatziantoniou, JC Dussaule	The FASEB Journal	2002
The therapeutic potential of endothelin receptor antagonists in cardiovascular disease M Barton, W Kiowski	Current Hypertension Reports	2001
Research on renal endothelin in proteinuric nephropathies dictates novel strategies to prevent progression A Benigni, N Perico, G Remuzzi	Current Opinion in Nephrology and Hypertension	2001
Endothelin: The yin and yang of ischemic acute renal failure R Safirstein	Kidney International	2001
ENDOTHELINSYSTEM: The Double-Edged Sword in Health and Disease RM Kedzierski, M Yanagisawa	Annual Review of Pharmacology and Toxicology	2001
Drug-induced acute interstitial nephritis J Rossert	Kidney International	2001
Role of endothelin-1 in lung disease KA Fagan, IF McMurtry, DM Rodman	Respiratory Research	2001
Increased Expression of Endothelin-1 and Inducible Nitric Oxide Synthase Isoform II in Aging Arteries in Vivo: Implications for Atherosclerosis W Goettsch, T Lattmann, K Amann, M Szibor, H Morawietz, K Münter, SP Müller, S Shaw, M Barton	Biochemical and Biophysical Research Communications	2001
An update on the status of endothelin receptor antagonists for hypertension HH Dao, P Moreau	Expert Opinion on Investigational Drugs	2001
Treatment prospects for autosomal-dominant polycystic kidney disease Q Qian, PC Harris, VE Torres	Kidney International	2001
Role of cellular infiltrates in response to proteinuria AA Eddy	American Journal of Kidney Diseases	2001
Conditional abatement of tissue fibrosis using nucleoside analogs to selectively corrupt DNA replication in transgenic fibroblasts M Iwano, A Fischer, H Okada, D Plieth, C Xue, TM Danoff, EG Neilson	Molecular Therapy	2001
Renal endothelin-1 and endothelin receptor type B expression in glomerular diseases with proteinuria I Lehrke, R Waldherr, E Ritz, J Wagner	Journal of the American Society of Nephrology : JASN	2001
Fibroblast Matrix Gene Expression and Connective Tissue Remodeling: Role of Endothelin-1 X Shi-wen, CP Denton, MR Dashwood, AM Holmes, G Bou-Gharios, JD Pearson, CM Black, DJ Abraham	Journal of Investigative Dermatology	2001
Contributions of angiotensin II and tumor necrosis factor-α to the development of renal fibrosis G Guo, J Morrissey, R McCracken, T Tolley, H Liapis, S Klahr	American journal of physiology. Renal physiology	2001
Plasma and urinary endothelin‐1 in focal segmental glomerulosclerosis HC Chen, JY Guh, JM Chang, JC Tsai, SJ Hwang, YH Lai	Journal of Clinical Laboratory Analysis	2001
Regression of Renal Vascular Fibrosis by Endothelin Receptor Antagonism JJ Boffa, PL Tharaux, JC Dussaule, C Chatziantoniou	Hypertension	2001
Endothelin and Its Inhibitors TD Warner		2001
Regulation of endothelin‐1 and transforming growth factor‐β1 production in cultured proximal tubular cells by albumin and heparan sulphate glycosaminoglycans BA Yard, E Chorianopoulos, D Herr, FJ van der Woude	Nephrology Dialysis Transplantation	2001
PreproEndothelin-1 Expression in Human Mesangial Cells: Evidence for a p38 Mitogen-Activated Protein Kinase/Protein Kinases-C—Dependent Mechanism M Foschi, A Sorokin, P Pratt, A Mcginty, GL VILLA, F Franchi, MJ Dunn	Journal of the American Society of Nephrology : JASN	2001
Proteinuria: Its clinical importance and role in progressive renal disease☆ WF Keane	American Journal of Kidney Diseases	2000
The renoprotective potential of endothelin receptor antagonists T Knoll, M Schaub, R Birck, C Braun, KP Juenemann, P Rohmeiss	Expert Opinion on Investigational Drugs	2000
Endothelin antagonists in renal disease A Benigni	Kidney International	2000
Importance of quantitative genetic variations in the etiology of hypertension O Smithies, HS Kim, N Takahashi, MH Edgell	Kidney International	2000
Is there a role for endothelin antagonists in diabetic renal disease? K Jandeleit-Dahm, TJ Allen, S Youssef, RE Gilbert, ME Cooper	Diabetes, Obesity and Metabolism	2000
An oral endothelin-A receptor antagonist blocks collagen synthesis and deposition in advanced rat liver fibrosis JJ Cho, B Hocher, H Herbst, JD Jia, M Ruehl, EG Hahn, EO Riecken, D Schuppan	Gastroenterology	2000
Apoptosis inhibition of cellular proliferation by II: possible implication and perspectives I Mucsi, L Rosivall, B Antus	Acta Physiologica Hungarica	2000
Endothelin and renal vascular fibrosis: of mice and men C Chatziantoniou, JC Dussaule	Current Opinion in Nephrology and Hypertension	2000
Understanding hypertension through genetic manipulation in mice B Cvetkovic, CD Sigmund	Kidney International	2000
ETA receptor blockade induces fibrosis of the clipped kidney in two-kidney-one-clip renovascular hypertensive rats B Hocher, I George, F Diekmann, R Zart, J Rebstock, A Schwarz, C Thöne-Reineke, HH Neumayer, C Bauer	Journal of Hypertension	2000
THE ROLE OF PODOCYTE INJURY IN THE PATHOGENESIS OF FOCAL SEGMENTAL GLOMERULOSCLEROSIS MM Schwartz	Renal Failure	2000
Transgenic animal models for the analysis of the renal endothelin system B Hocher, M Paul	Nephrology Dialysis Transplantation	2000
Pulmonary Fibrosis and Chronic Lung Inflammation in ET-1 Transgenic Mice B Hocher, A Schwarz, KA Fagan, C Thöne-Reineke, K El-Hag, H Kusserow, S Elitok, C Bauer, HH Neumayer, DM Rodman, F Theuring	American journal of respiratory cell and molecular biology	2000
A Cytokine Reborn?: Endothelin-1 in Pulmonary Inflammation and Fibrosis P Teder, PW Noble	American journal of respiratory cell and molecular biology	2000
The role of vasoactive compounds, growth factors and cytokines in the progression of renal disease S Klahr, JJ Morrissey	Kidney International	2000
Endothelial Cell-Specific Regulation of the Murine Endothelin-1 Gene: BM Fadel, SC Boutet, T Quertermous	Journal of Cardiovascular Pharmacology	2000
Transgenic Models for the Study of Endothelin Function in the Cardiovascular System: FS Zollmann, M Paul	Journal of Cardiovascular Pharmacology	2000
Endothelins and Endothelin Receptor Antagonists: Therapeutic Considerations for a Novel Class of Cardiovascular Drugs TF Lüscher, M Barton	Circulation	2000
Selective ET A Receptor Antagonism with ABT-627 Attenuates All Renal Effects of Endothelin in Humans ML Honing, ML Hijmering, DA Ballard, YP Yang, RJ Padley, PJ Morrison, TJ Rabelink	Journal of the American Society of Nephrology : JASN	2000
THE MOLECULAR BASIS OF HYPERTENSION DL Garbers, SK Dubois	Annual Review of Biochemistry	1999
Different roles of two types of endothelin receptors in partial ablation-induced chronic renal failure in rats T Shimizu, S Hata, T Kuroda, S Mihara, M Fujimoto	European Journal of Pharmacology	1999
Macrophage and myofibroblast involvement in ischemic acute renal failure is attenuated by endothelin receptor antagonists JM Forbes, B Leaker, TD Hewitson, GJ Becker, CL Jones	Kidney International	1999
Endothelin antagonists for hypertension and renal disease M Barton, TF Luscher	Current Opinion in Nephrology and Hypertension	1999
Endothelin antagonists A Benigni, G Remuzzi	The Lancet	1999
Bosentan reduces blood pressure and the target-organ damage induced by a high-fructose diet in rats A Cosenzi, E Bernobich, N Plazzotta, P Seculin, G Bellini	Journal of Hypertension	1999
Antihypertensive therapy and progression of chronic renal disease LD Dworkin, DG Shemin	Current Hypertension Reports	1999
Endothelin and its antagonists in hypertension: Can we foresee the future? P Moreau, TJ Rabelink	Current Hypertension Reports	1999
PREVENTION OF CHRONIC RENAL ALLOGRAFT REJECTION IN RATS WITH AN ORAL ENDOTHELIN A RECEPTOR ANTAGONIST1: C Braun, T Conzelmann, S Vetter, M Schaub, WE Back, B Yard, M Kirchengast, SG Tullius, P Schnlle, FJ van der Woude, P Rohmeiss	Transplantation	1999
Endothelin System–Dependent Cardiac Remodeling in Renovascular Hypertension B Hocher, I George, J Rebstock, A Bauch, A Schwarz, HH Neumayer, C Bauer	Hypertension	1999
Vascular Endothelin-1 Gene Expression and Synthesis and Effect on Renal Type I Collagen Synthesis and Nephroangiosclerosis During Nitric Oxide Synthase Inhibition in Rats PL Tharaux, C Chatziantoniou, D Casellas, L Fouassier, R Ardaillou, JC Dussaule	Circulation	1999
Volume Stress-Induced Peritoneal Endothelin-1 Release in Continuous Ambulatory Peritoneal Dialysis S Morgera, S Kuchinke, K Budde, A Lun, B Hocher, HH Neumayer	Journal of the American Society of Nephrology : JASN	1999
Acute and Chronic Renal Effects of Recombinant Human TGF-β2 in the Rat FJ Kelly, S Anderson, MM Thompson, TT Oyama, TM Kennefick, CL Corless, RJ Roman, L Kurtzberg, BM Pratt, SR Ledbetter	Journal of the American Society of Nephrology : JASN	1999
Nitric oxide inhibition induces early activation of type I collagen gene in renal resistance vessels and glomeruli in transgenic mice. Role of endothelin C Chatziantoniou, JJ Boffa, R Ardaillou, JC Dussaule	Journal of Clinical Investigation	1998
Renoprotective effect of contemporary blocking of angiotensin II and endothelin-1 in rats with membranous nephropathy1 A Benigni, D Corna, R Maffi, G Benedetti, C Zoja, G Remuzzi	Kidney International	1998
Angiotensin II and endothelin in chronic glomerulonephritis DE Kohan	Kidney International	1998
Ischemic renal diseases: New insights into old entities A Meyrier, GS Hill, P Simon	Kidney International	1998
Hypertension P Hamet, Z Pausova, V Adarichev, K Adaricheva, J Tremblay	Journal of Hypertension	1998
Apoptosis in Kidneys of Endothelin-1 Transgenic Mice B Hocher, P Rohmeiss, C Thöne-Reineke, A Schwarz, V Burst, F der Woude, C Bauer, NA Theuring	Journal of Cardiovascular Pharmacology	1998
Pathophysiology in Endothelin-1 Transgenic Mice F Theuring, C Thöne-Reinecke, H Vogler, F Schmager, P Rohmeiss, T Slowinski, HH Neumayer, B Hocher	Journal of Cardiovascular Pharmacology	1998
Renal Endothelin System in Diabetes: Comparison of Angiotensin-Converting Enzyme Inhibition and Endothelin-A Antagonism B Hocher, A Lun, F Priem, HH Neumayer, M Raschack	Journal of Cardiovascular Pharmacology	1998
The Endothelin System in Polycystic Kidneys of Han:SPRD Rats B Hocher, R Zart, N Braun, A Schwarz, F der Woude, P Rohmeiss, K Koppenhagen	Journal of Cardiovascular Pharmacology	1998
Dynamic Regulation of β-Adrenergic Receptors by Endothelin-1 in Smooth-Muscle Cells BR Brehm, M Zvizdic, R Bernhard, HM Hoffmeister, SC Wolf, KR Karsch	Journal of Cardiovascular Pharmacology	1998
The role of endothelin in hypertension L Rothermund, M Paul	Current Opinion in Nephrology and Hypertension	1998
Pathophysiology of Progressive Nephropathies FH Epstein, G Remuzzi, T Bertani	New England Journal of Medicine	1998
Transforming growth factor β1 and renal disease in African Americans S Klahr	Kidney International	1998
Transgenesis and Gene Targeting in the Mouse DE Stec, RL Davisson, CD Sigmund	Trends in Cardiovascular Medicine	1998
The role of endothelin in the age dependent increase in renal vascularresistance in the rat kidney Z Greenfeld, K Engels, L Samsell, C Baylis	Mechanisms of Ageing and Development	1998
ET A Receptor Blockade Prevents Increased Tissue Endothelin-1, Vascular Hypertrophy, and Endothelial Dysfunction in Salt-Sensitive Hypertension M Barton, LV dUscio, S Shaw, P Meyer, P Moreau, TF Lüscher	Hypertension	1998
Pulmonary Actions of the Endothelins RG Goldie, DW Hay		1998
Angiotensin II Increases Vascular and Renal Endothelin-1 and Functional Endothelin Converting Enzyme Activityin Vivo:Role of ETAReceptors for Endothelin Regulation M Barton, S Shaw, LV d'uscio, P Moreau, TF Lüscher	Biochemical and Biophysical Research Communications	1997
Biology of the Endothelium TF Lüscher, M Barton	Clinical Cardiology	1997
Sodium and Water Homeostasis H Trachtman	Pediatric Clinics of North America	1995

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