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Citations to this article

Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.
A De Vos, … , D Pipeleers, F Schuit
A De Vos, … , D Pipeleers, F Schuit
Published November 1, 1995
Citation Information: J Clin Invest. 1995;96(5):2489-2495. https://doi.org/10.1172/JCI118308.
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Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.

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Abstract

Glucose homeostasis is controlled by a glucose sensor in pancreatic beta-cells. Studies on rodent beta-cells have suggested a role for GLUT2 and glucokinase in this control function and in mechanisms leading to diabetes. Little direct evidence exists so far to implicate these two proteins in glucose recognition by human beta-cells. The present in vitro study investigates the role of glucose transport and phosphorylation in beta-cell preparations from nondiabetic human pancreata. Human beta-cells differ from rodent beta-cells in glucose transporter gene expression (predominantly GLUT1 instead of GLUT2), explaining their low Km (3 mmol/liter) and low VMAX (3 mmol/min per liter) for 3-O-methyl glucose transport. The 100-fold lower GLUT2 abundance in human versus rat beta-cells is associated with a 10-fold slower uptake of alloxan, explaining their resistance to this rodent diabetogenic agent. Human and rat beta-cells exhibit comparable glucokinase expression with similar flux-generating influence on total glucose utilization. These data underline the importance of glucokinase but not of GLUT2 in the glucose sensor of human beta-cells.

Authors

A De Vos, H Heimberg, E Quartier, P Huypens, L Bouwens, D Pipeleers, F Schuit

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Diabetes 2014
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SE Flanagan, ED Franco, HL Allen, M Zerah, MM Abdul-Rasoul, JA Edge, H Stewart, E Alamiri, K Hussain, S Wallis, L Vries, O Rubio-Cabezas, JA Houghton, EL Edghill, AM Patch, S Ellard, AT Hattersley
Cell Metabolism 2014
New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout mice
GG Holz, CA Leech, OG Chepurny
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2014
Glucose homeostasis and the enteroinsular axis in the horse: A possible role in equine metabolic syndrome
E Graaf-Roelfsema
The Veterinary Journal 2014
Glucose regulation of glucagon secretion
E Gylfe, P Gilon
Diabetes Research and Clinical Practice 2014
Cellular Endocrinology in Health and Disease
AA Bremer, WL Miller
Cellular Endocrinology in Health and Disease 2014
Effect of early life stress on pancreatic isolated islets’ insulin secretion in young adult male rats subjected to chronic stress
F Sadeghimahalli, R Karbaschi, H Zardooz, F Khodagholi, F Rostamkhani
Endocrine 2014
Potential role of skeletal muscle glucose metabolism on the regulation of insulin secretion: Organ crosstalk and insulin secretion
ML Mizgier, M Casas, A Contreras-Ferrat, P Llanos, JE Galgani
Obesity Reviews 2014
Nutrient regulation of insulin secretion and action
P Newsholme, V Cruzat, F Arfuso, K Keane
Journal of Endocrinology 2014
Transcriptomic analysis of the lesser spotted catshark (Scyliorhinus canicula) pancreas, liver and brain reveals molecular level conservation of vertebrate pancreas function
JF Mulley, AD Hargreaves, MJ Hegarty, RS Heller, MT Swain
BMC Genomics 2014
A Fresh View of Glycolysis and Glucokinase Regulation: History and Current Status
S Lenzen
The Journal of biological chemistry 2014
Pathobiology of Human Disease
S Akilesh
Pathobiology of Human Disease 2014
Neural regulation of pancreatic islet cell mass and function
B Thorens
Diabetes Obesity and Metabolism 2014
Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes
P Gilon, HY Chae, GA Rutter, MA Ravier
Cell Calcium 2014
Reference Module in Biomedical Sciences
DL Sackett, RB Haynes
2014
Islets of Langerhans, 2. ed
MS Islam
Islets of Langerhans, 2. ed. 2014
Impaired Islet Function in Commonly Used Transgenic Mouse Lines due to Human Growth Hormone Minigene Expression
B Brouwers, G de Faudeur, AB Osipovich, L Goyvaerts, K Lemaire, L Boesmans, EJ Cauwelier, M Granvik, VP Pruniau, L Van Lommel, J Van Schoors, JS Stancill, I Smolders, V Goffin, N Binart, P int Veld, J Declercq, MA Magnuson, JW Creemers, F Schuit, A Schraenen
Cell Metabolism 2014
Islets of Langerhans
S Islam
2014
Nervous control of postnatal beta-cell proliferation and glucose homeostasis
David Tarussio, Salima Metref, Pascal Seyer, Lourdes Mounien, David Vallois, Christophe Magnan, Marc Foretz, Bernard Thorens
Journal of Clinical Investigation 2013
Islet β cell mass in diabetes and how it relates to function, birth, and death
GC Weir, S Bonner-Weir
Annals of the New York Academy of Sciences 2013
Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice
JE Bruin, A Rezania, J Xu, K Narayan, JK Fox, JJ O’Neil, TJ Kieffer
Diabetologia 2013
Sympathetic Innervation during Development Is Necessary for Pancreatic Islet Architecture and Functional Maturation
P Borden, J Houtz, SD Leach, R Kuruvilla
Cell Reports 2013
Glucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cell
JT Low, JM Mitchell, OH Do, J Bax, A Rawlings, M Zavortink, G Morgan, RG Parton, HY Gaisano, P Thorn
Diabetologia 2013
Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells
JE Bruin, S Erener, J Vela, X Hu, JD Johnson, HT Kurata, FC Lynn, JM Piret, A Asadi, A Rezania, TJ Kieffer
Stem Cell Research 2013
Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo
A Rezania, JE Bruin, J Xu, K Narayan, JK Fox, JJ O'Neil, TJ Kieffer
Stem Cells 2013
Regulation of Insulin Secretion in Human Pancreatic Islets
P Rorsman, M Braun
Annual Review of Physiology 2013
N-glycosylation modulates the membrane sub-domain distribution and activity of glucose transporter 2 in pancreatic beta cells
K Ohtsubo, S Takamatsu, C Gao, H Korekane, TM Kurosawa, N Taniguchi
Biochemical and Biophysical Research Communications 2013
Metabolic Signaling in Fuel-Induced Insulin Secretion
M Prentki, FM Matschinsky, SR Madiraju
Cell Metabolism 2013
Parp1 deficient mice are protected from streptozotocin-induced diabetes but not caerulein-induced pancreatitis, independent of the induction of Reg family genes
B Li, C Luo, S Chowdhury, ZH Gao, JL Liu
Regulatory Peptides 2013
Glucose-stimulated insulin secretion: the hierarchy of its multiple cellular and subcellular mechanisms
P Meda, F Schuit
Diabetologia 2013
Influence of melatonin receptor signalling on parameters involved in blood glucose regulation
I Bazwinsky-Wutschke, L Bieseke, E Mühlbauer, E Peschke
Journal of Pineal Research 2013
Congenital Hyperinsulinism Caused by Hexokinase I Expression or Glucokinase-Activating Mutation in a Subset of  -Cells
JC Henquin, C Sempoux, J Marchandise, S Godecharles, Y Guiot, M Nenquin, J Rahier
Diabetes 2012
Involvement of heparan sulfate 3-O-sulfotransferase isoform-1 in the insulin secretion pathway
I Takahashi, K Ohashi, K Nata
Journal of Diabetes Investigation 2012
Diabetes Mellitus and the β Cell: The Last Ten Years
FM Ashcroft, P Rorsman
Cell 2012
The SLC2 (GLUT) family of membrane transporters
M Mueckler, B Thorens
Molecular Aspects of Medicine 2012
High-fat diet consumption during pregnancy and the early post-natal period leads to decreased α cell plasticity in the nonhuman primate
SM Comstock, LD Pound, JM Bishop, DL Takahashi, AM Kostrba, MS Smith, KL Grove
Molecular Metabolism 2012
Cholesterol‐enriched membrane rafts and insulin secretion
R Dirkx, M Solimena
Journal of Diabetes Investigation 2012
The pancreatic beta cell surface proteome
I Stützer, D Esterházy, M Stoffel
Diabetologia 2012
Regeneration of pancreatic beta-cell mass for the treatment of diabetes
J Domínguez-Bendala, L Inverardi, C Ricordi
Expert Opinion on Biological Therapy 2012
SLC2A2 mutations can cause neonatal diabetes, suggesting GLUT2 may have a role in human insulin secretion
FH Sansbury, SE Flanagan, JA Houghton, FL Shen, AM Al-Senani, AM Habeb, M Abdullah, A Kariminejad, S Ellard, AT Hattersley
Diabetologia 2012
GLP-1 receptor activated insulin secretion from pancreatic β-cells: mechanism and glucose dependence
AR Meloni, MB DeYoung, C Lowe, DG Parkes
Diabetes, Obesity and Metabolism 2012
A tale of two glucose transporters: how GLUT2 re-emerged as a contender for glucose transport into the human beta cell
M Bunt, AL Gloyn
Diabetologia 2012
Restoring insulin production for type 1 diabetes: Restoring insulin for diabetes
E Tudurí, JE Bruin, TJ Kieffer
Journal of Diabetes 2012
Metabolite profiling reveals normal metabolic control in carriers of mutations in the glucokinase gene (MODY2)
P Spégel, E Ekholm, T Tuomi, L Groop, H Mulder, K Filipsson
Diabetes 2012
Zinc transporters and their role in the pancreatic β‐cell
K Lemaire, F Chimienti, F Schuit
Journal of Diabetes Investigation 2012
Computational Modeling of Glucose Transport in Pancreatic β-Cells Identifies Metabolic Thresholds and Therapeutic Targets in Diabetes
C Luni, JD Marth, FJ Doyle, F Castiglione
PloS one 2012
Overcoming the spatial barriers of the stimulus secretion cascade in pancreatic β-cells
PR Huypens, M Huang, JW Joseph
Islets 2012
 -Cell-Specific Gene Repression: A Mechanism to Protect Against Inappropriate or Maladjusted Insulin Secretion?
F Schuit, LV Lommel, M Granvik, L Goyvaerts, G Faudeur, A Schraenen, K Lemaire
Diabetes 2012
SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells
B Kailey, M de Bunt, S Cheley, PR Johnson, PE MacDonald, AL Gloyn, P Rorsman, M Braun
American journal of physiology. Endocrinology and metabolism 2012
Human Insulin Secreted from Insulinogenic Xenograft Restores Normoglycemia in Type 1 Diabetic Mice without Immunosuppression
J Kim, S Park, HM Kang, CW Ahn, HC Kwon, JH Song, YJ Lee, KH Lee, H Yang, SY Baek, SH Yoo, SH Kim, H Kim
Cell Transplantation 2012
A tale of two glucose transporters: how GLUT2 re-emerged as a contender for glucose transport into the human beta cell
M van de Bunt, AL Gloyn
Diabetologia 2012
A genetically-engineered human pancreatic beta cell line with glucose-inducible insulin secretion
Philippe Ravassard, Yasmine Hazhouz, Severine Pechberty, Emilie Bricou-Neveu, Mathieu Armanet, Paul Czernichow, Raphaël Scharfmann
Journal of Clinical Investigation 2011
Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets
C Dai, M Brissova, Y Hang, C Thompson, G Poffenberger, A Shostak, Z Chen, R Stein, AC Powers
Diabetologia 2011
Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport
K Ohtsubo, MZ Chen, JM Olefsky, JD Marth
Nature Medicine 2011
Oxidative Stress and Disease
I Paur, M Carlsen, B Halvorsen, R Blomhoff
Herbal Medicine 2011
Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription
Z Xu, G Wei, I Chepelev, K Zhao, G Felsenfeld
Nature Structural & Molecular Biology 2011
New type 2 diabetes risk genes provide new insights in insulin secretion mechanisms
SA Schäfer, F Machicao, A Fritsche, HU Häring, K Kantartzis
Diabetes Research and Clinical Practice 2011
GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: Implications for understanding genetic association signals at this locus
LJ McCulloch, M de Bunt, M Braun, KN Frayn, A Clark, AL Gloyn
Molecular Genetics and Metabolism 2011
Persistent glucose transporter expression on pancreatic beta cells from longstanding type 1 diabetic individuals
KT Coppieters, A Wiberg, N Amirian, TW Kay, MG von Herrath
Diabetes/Metabolism Research and Reviews 2011
The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells
CL Basford, KJ Prentice, AB Hardy, F Sarangi, SJ Micallef, X Li, Q Guo, AG Elefanty, EG Stanley, G Keller, EM Allister, MC Nostro, MB Wheeler
Diabetologia 2011
Ultrastructural analysis, zinc transporters, glucose transporters and hormones expression in new world primate (Callithrix jacchus) and human pancreatic islets
D Mohanasundaram, C Drogemuller, J Brealey, CF Jessup, C Milner, C Murgia, CJ Lang, A Milton, PD Zalewski, GR Russ, PT Coates
General and Comparative Endocrinology 2011
The central role of calcium in the effects of cytokines on beta-cell function: implications for type 1 and type 2 diabetes
JW Ramadan, SR Steiner, CM O'Neill, CS Nunemaker
Cell Calcium 2011
Pancreatic islet-specific overexpression of Reg3β protein induced the expression of pro-islet genes and protected the mice against streptozotocin-induced diabetes mellitus
X Xiong, X Wang, B Li, S Chowdhury, Y Lu, CB Srikant, G Ning, JL Liu
American journal of physiology. Endocrinology and metabolism 2011
Differences between Human and Rodent Pancreatic Islets: LOW PYRUVATE CARBOXYLASE, ATP CITRATE LYASE, AND PYRUVATE CARBOXYLATION AND HIGH GLUCOSE-STIMULATED ACETOACETATE IN HUMAN PANCREATIC ISLETS
MJ MacDonald, MJ Longacre, SW Stoker, M Kendrick, A Thonpho, LJ Brown, NM Hasan, S Jitrapakdee, T Fukao, MS Hanson, LA Fernandez, J Odorico
The Journal of biological chemistry 2011
Atlas of Diabetes
J Skyler
2011
Transient Receptor Potential Channels
S Islam
Transient Receptor Potential Channels 2010
Transient Receptor Potential Channels
S Islam
Transient Receptor Potential Channels 2010
Transient Receptor Potential Channels
S Islam
Transient Receptor Potential Channels 2010
Transient Receptor Potential Channels
S Islam
Transient Receptor Potential Channels 2010
Transient Receptor Potential Channels
S Islam
Transient Receptor Potential Channels 2010
Transient Receptor Potential Channels
S Islam
Transient Receptor Potential Channels 2010
Transient Receptor Potential Channels
S Islam
Transient Receptor Potential Channels 2010
Transient Receptor Potential Channels
S Islam
Transient Receptor Potential Channels 2010
Transient Receptor Potential Channels
S Islam
Transient Receptor Potential Channels 2010
Transient Receptor Potential Channels
S Islam
Transient Receptor Potential Channels 2010
Transient Receptor Potential Channels
S Islam
Transient Receptor Potential Channels 2010
Transient Receptor Potential Channels
S Islam
Transient Receptor Potential Channels 2010
Transient Receptor Potential Channels
S Islam
Transient Receptor Potential Channels 2010
Transient Receptor Potential Channels
S Islam
Transient Receptor Potential Channels 2010
Transient Receptor Potential Channels
S Islam
Transient Receptor Potential Channels 2010
Transient Receptor Potential Channels
S Islam
Transient Receptor Potential Channels 2010
Transient Receptor Potential Channels
S Islam
Transient Receptor Potential Channels 2010
Transient Receptor Potential Channels
S Islam
Transient Receptor Potential Channels 2010
Transient Receptor Potential Channels
S Islam
Transient Receptor Potential Channels 2010
Transient Receptor Potential Channels
S Islam
Transient Receptor Potential Channels 2010
Transient Receptor Potential Channels
S Islam
Transient Receptor Potential Channels 2010
Transient Receptor Potential Channels
S Islam
Transient Receptor Potential Channels 2010
Calcineurin Signaling Regulates Human Islet β-Cell Survival*
SA Soleimanpour, MF Crutchlow, AM Ferrari, JC Raum, DN Groff, MM Rankin, C Liu, DD de León, A Naji, JA Kushner, DA Stoffers
The Journal of biological chemistry 2010
Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD–severe combined immunodeficiency (SCID) mice
HE Levitt, TJ Cyphert, JL Pascoe, DA Hollern, N Abraham, RJ Lundell, T Rosa, LC Romano, B Zou, CP O'Donnell, AF Stewart, A Garcia-Ocaña, LC Alonso
Diabetologia 2010
Induction of Human  -Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6
NM Fiaschi-Taesch, F Salim, J Kleinberger, R Troxell, I Cozar-Castellano, K Selk, E Cherok, KK Takane, DK Scott, AF Stewart
Diabetes 2010
The role of peroxisome proliferator-activated receptor γ in pancreatic β cell function and survival: therapeutic implications for the treatment of type 2 diabetes mellitus
D Gupta, T Kono, C Evans-Molina
Diabetes, Obesity and Metabolism 2010
Textbook of Diabetes
PM Jones, SJ Persaud
Textbook of Diabetes 2010
The protein family of glucose transport facilitators: It's not only about glucose after all
R Augustin
IUBMB Life 2010
Brain Glucose Transporter Protein 2 and Sporadic Alzheimer's Disease
M Šalković-Petrišić, P Riederer
Translational Neuroscience 2010
Cloning and molecular characterization of the glucose transporter 1 in tilapia (Oreochromis niloticus)
O Hrytsenko, B Pohajdak, BY Xu, C Morrison, B vanTol, JR Wright
General and Comparative Endocrinology 2010
Vitamins & Hormones
KJ Hare, FK Knop
Vitamins & Hormones 2010
xPharm: The Comprehensive Pharmacology Reference
A Vinh
xPharm: The Comprehensive Pharmacology Reference 2010
Calcineurin Signaling Regulates Human Islet β-Cell Survival
SA Soleimanpour, MF Crutchlow, AM Ferrari, JC Raum, DN Groff, MM Rankin, C Liu, DD de León, A Naji, JA Kushner, DA Stoffers
The Journal of biological chemistry 2010
Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes
L Marselli, J Thorne, S Dahiya, DC Sgroi, A Sharma, S Bonner-Weir, P Marchetti, GC Weir, P Westermark
PloS one 2010
Effects of the HIV Protease Inhibitor Ritonavir on GLUT4 Knock-out Mice
AK Vyas, JC Koster, A Tzekov, PW Hruz
The Journal of biological chemistry 2010
Protein Markers for Insulin-Producing Beta Cells with Higher Glucose Sensitivity
GA Martens, L Jiang, K Verhaeghen, JB Connolly, SG Geromanos, G Stangé, LV Oudenhove, B Devreese, KH Hellemans, Z Ling, CV Schravendijk, DG Pipeleers, JP Vissers, FK Gorus, K Maedler
PloS one 2010
Glucose Suppression of Glucagon Secretion: METABOLIC AND CALCIUM RESPONSES FROM α-CELLS IN INTACT MOUSE PANCREATIC ISLETS
SJ le Marchand, DW Piston
The Journal of biological chemistry 2010
BetaSys: Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells
B Booß-Bavnbek, B Klösgen, J Larsen, F Pociot, E Renström
2010
Metabolisme
FC Schuit
2010
Structure, Function, and Regulation of Insulin-Degrading Enzyme
RE Hulse, LA Ralat, WJ Tang
Vitamins and hormones 2009
Noninvasive imaging of pancreatic β cells
WJ Malaisse, K Louchami, A Sener
Nature Reviews Endocrinology 2009
The glucose transporter 2 undergoes plasma membrane endocytosis and lysosomal degradation in a secretagogue-dependent manner
JC Hou, D Williams, J Vicogne, JE Pessin
Endocrinology 2009
GLUT2 mutations, translocation, and receptor function in diet sugar managing
A Leturque, E Brot-Laroche, ML Gall
American journal of physiology. Endocrinology and metabolism 2009
Stem Cell Therapy for Diabetes
S Efrat
2009
Beta cells within single human islets originate from multiple progenitors
R Scharfmann, X Xiao, H Heimberg, J Mallet, P Ravassard
PloS one 2008
Voltage-Gated Ion Channels in Human Pancreatic  -Cells: Electrophysiological Characterization and Role in Insulin Secretion
M Braun, R Ramracheya, M Bengtsson, Q Zhang, J Karanauskaite, C Partridge, PR Johnson, P Rorsman
Diabetes 2008
Expanding human beta cells
R Scharfmann
Diabetologia 2008
Cx36 makes channels coupling human pancreatic  -cells, and correlates with insulin expression
V Serre-Beinier, D Bosco, L Zulianello, A Charollais, D Caille, E Charpantier, BR Gauthier, GR Diaferia, BN Giepmans, R Lupi, P Marchetti, S Deng, L Buhler, T Berney, V Cirulli, P Meda
Human Molecular Genetics 2008
Beta Cells within Single Human Islets Originate from Multiple Progenitors
R Scharfmann, X Xiao, H Heimberg, J Mallet, P Ravassard, T Chan-Ling
PloS one 2008
Mechanisms and Outcomes of Drug- and Toxicant-Induced Liver Toxicity in Diabetes
T Wang, K Shankar, MJ Ronis, HM Mehendale
Critical Reviews in Toxicology 2007
Mechanisms of action of glucagon-like peptide 1 in the pancreas
ME Doyle, JM Egan
Pharmacology & Therapeutics 2007
Embryonic stem cell therapy for diabetes mellitus
K Docherty, AS Bernardo, L Vallier
Seminars in Cell & Developmental Biology 2007
Low levels of glucose transporters and % MathType!Translator!2!1!AMS LaTeX.tdl!TeX -- AMS-LaTeX! % MathType!MTEF!2!1!+- % feaaeaart1ev0aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbbjxAHX % garmWu51MyVXgatuuDJXwAK1uy0HwmaeHbfv3ySLgzG0uy0Hgip5wz % aebbnrfifHhDYfgasaacH8qrps0lbbf9q8WrFfeuY-Hhbbf9v8qqaq % Fr0xc9pk0xbba9q8WqFfea0-yr0RYxir-Jbba9q8aq0-yq-He9q8qq % Q8frFve9Fve9Ff0dmeaabaqaciGacaGaaeqabaWaaeWaeaaakeaaca % WGlbWaa0baaSqaaiaadgeacaWGubGaamiuaaqaaiabgUcaRaaaaaa!3BE3! $$ K^{ + }_{{ATP}} $$ channels in human pancreatic beta cells early in development
CC Richardson, K Hussain, PM Jones, S Persaud, K Löbner, A Boehm, A Clark, MR Christie
Diabetologia 2007
Paradoxical stimulation of glucagon secretion by high glucose concentrations
A Salehi, E Vieira, E Gylfe
Diabetes 2006
Transcriptional regulation of metabolism
B Desvergne, L Michalik, W Wahli
Physiological reviews 2006
Nutrient Control of Insulin Secretion in Isolated Normal Human Islets
JC Henquin, D Dufrane, M Nenquin
Diabetes 2006
Differential subcellular distribution of glucose transporters GLUT1–6 and GLUT9 in human cancer: Ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues
A Godoy, V Ulloa, F Rodríguez, K Reinicke, AJ Yañez, MA los García, RA Medina, M Carrasco, S Barberis, T Castro, F Martínez, X Koch, JC Vera, MT Poblete, CD Figueroa, B Peruzzo, F Pérez, F Nualart
Journal of Cellular Physiology 2006
Things we have learned from tilapia islet xenotransplantation
EL Alexander, KC Dooley, B Pohajdak, BY Xu, JR Wright
General and Comparative Endocrinology 2006
Glucose-sensing mechanisms in pancreatic  -cells
PE MacDonald, JW Joseph, P Rorsman
Philosophical Transactions of the Royal Society B: Biological Sciences 2005
The role of GLUT2 in dietary sugar handling
A Leturque, E Brot-Laroche, M Gall, E Stolarczyk, V Tobin
Journal of Physiology and Biochemistry 2005
Effects of prolonged in vitro exposure to sulphonylureas on the function and survival of human islets
SD Guerra, L Marselli, R Lupi, U Boggi, F Mosca, L Benzi, SD Prato, P Marchetti
Journal of Diabetes and its Complications 2005
Loss of ARNT/HIF1β Mediates Altered Gene Expression and Pancreatic-Islet Dysfunction in Human Type 2 Diabetes
JE Gunton, RN Kulkarni, SH Yim, T Okada, WJ Hawthorne, YH Tseng, RS Roberson, C Ricordi, PJ O’Connell, FJ Gonzalez, CR Kahn
Cell 2005
International Review of Neurobiology
ZT Bloomgarden
International review of neurobiology 2005
The role of GLUT2 in dietary sugar handling
A Leturque, E Brot-Laroche, ML Gall, E Stolarczyk, V Tobin
Journal of Physiology and Biochemistry 2005
Developmental biology of the pancreas
PL Merino
Cell Biochemistry and Biophysics 2004
Tilapia islet grafts are highly alloxan-resistant
BY Xu, CM Morrison, H Yang, JR Wright
General and Comparative Endocrinology 2004
Hyperinsulinism in Infancy: From Basic Science to Clinical Disease
MJ Dunne, KE Cosgrove, RM Shepherd, A Aynsley-Green, KJ Lindley
Physiological reviews 2004
Establishment and Application of in Vitro Membrane Potential Assays in Cell Lines with Endogenous or Recombinant Expression of ATP-Sensitive Potassium Channels (Kir6.2/SUR1) Using a Fluorescent Probe Kit
P Arkhammar, P Wahl, B Gerlach, T Fremming, JB Hansen
Journal of biomolecular screening 2004
HIV protease inhibitors acutely impair glucose-stimulated insulin release
JC Koster, MS Remedi, H Qiu, CG Nichols, PW Hruz
Diabetes 2003
International Textbook of Diabetes Mellitus
RA DeFronzo, L Mandarino, E Ferrannini
International Textbook of Diabetes Mellitus 2003
Broad expression of fructose-1,6-bisphosphatase and phosphoenolpyruvate carboxykinase provide evidence for gluconeogenesis in human tissues other than liver and kidney: EXPRESSION OF FBPase AND PEPCK IN ADULT HUMAN TISSUES
AJ Yánez, F Nualart, C Droppelmann, R Bertinat, M Brito, II Concha, JC Slebe
Journal of Cellular Physiology 2003
Membrane Transporter Diseases
S Bröer, CA Wagner
2003
Mechanism underlying resistance of human pancreatic beta cells against toxicity of streptozotocin and alloxan
M Elsner, M Tiedge, S Lenzen
Diabetologia 2003
Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3
Y Heremans, MV de Casteele, P Veld, G Gradwohl, P Serup, O Madsen, D Pipeleers, H Heimberg
The Journal of Cell Biology 2002
Glucokinase Is the Likely Mediator of Glucosensing in Both Glucose-Excited and Glucose-Inhibited Central Neurons
AA Dunn-Meynell, VH Routh, L Kang, L Gaspers, BE Levin
Diabetes 2002
Human β Cells Are Exceedingly Resistant to Streptozotocin in Vivo
H Yang, JR Wright
Endocrinology 2002
Differential sensitivity of GLUT1- and GLUT2-expressing beta cells to streptozotocin
M Hosokawa, W Dolci, B Thorens
Biochemical and Biophysical Research Communications 2001
Differential sensitivity of GLUT1- and GLUT2-expressing beta cells to streptozotocin
M Hosokawa, W Dolci, B Thorens
Biochemical and Biophysical Research Communications 2001
Glucose Sensing in Pancreatic  -Cells: A Model for the Study of Other Glucose-Regulated Cells in Gut, Pancreas, and Hypothalamus
FC Schuit, P Huypens, H Heimberg, DG Pipeleers
Diabetes 2001
Terapia gênica para o diabetes
C Demeterco, F Levine
Arquivos brasileiros de endocrinologia e metabologia 2001
Molecular Basis of Pancreas Development and Function
JF Habener, MA Hussain
2001
Characterization and partial purification of liver glucose transporter GLUT2
M Lachaal, AL Rampal, J Ryu, W Lee, JS Hah, CY Jung
Biochimica et Biophysica Acta (BBA) - Biomembranes 2000
Subcellular localization of aldolase B
DE S�ez, JC Slebe
Journal of Cellular Biochemistry 2000
The Role of Glucose and Its Metabolism in the Regulation of Glucokinase Expression in Isolated Human Pancreatic Islets
R Gasa, ME Fabregat, R Gomis
Biochemical and Biophysical Research Communications 2000
Transgenic Reexpression of GLUT1 or GLUT2 in Pancreatic β Cells Rescues GLUT2-null Mice from Early Death and Restores Normal Glucose-stimulated Insulin Secretion
B Thorens, MT Guillam, F Beermann, R Burcelin, M Jaquet
The Journal of biological chemistry 2000
Human Islets in Mixed Islet Grafts Protect Mouse Pancreatic β-Cells from Alloxan Toxicity
B Tyrberg, DL Eizirik, SL Marklund, B Olejnicka, OD Madsen, A Andersson
Pharmacology & Toxicology 1999
Human islets of Langerhans express theδC isoform of calcium/calmodulin-dependent protein kinase II
L Southam, R Ashfield, R Cox, M Lathrop, SJ Ashcroft
Diabetes/Metabolism Research and Reviews 1999
Expression of the hexose transporters GLUT1 and GLUT2 during the early development of the human brain
F Nualart, A Godoy, K Reinicke
Brain Research 1999
Structure, function and regulation of pyruvate carboxylase
S Jitrapakdee, JC Wallace
Biochemical Journal 1999
Cellular origin of hexokinase in pancreatic islets
F Schuit, K Moens, H Heimberg, D Pipeleers
The Journal of biological chemistry 1999
Streptozotocin Dose–Response Curve in Tilapia, a Glucose-Responsive Teleost Fish
JR Wright, C Abraham, BC Dickson, H Yang, CM Morrison
General and Comparative Endocrinology 1999
Whole body glucose metabolism
K Zierler
American journal of physiology. Endocrinology and metabolism 1999
Inhibition of glucose-induced insulin release by 3-O-methyl-D-glucose: enzymatic, metabolic and cationic determinants
A Sener, O Scruel, K Louchami, H Jijakli, W J Malaisse
Molecular and Cellular Biochemistry 1999
Les transporteurs d'hexoses chez l'homme: leur rôle dans l'insulinosensibilité des tissus périphériques
JP Bastard, C Jardel, M Guerre-Millo, B Hainque
La Revue de Médecine Interne 1998
D-Glucose Combined Chronic Toxicity and Carcinogenicity Studdjs in Sprague-Dawley Rats and Syrian Golden Hamsters
E Bomhard, H Bischoff, H Mager, F Krötlinger, B Schilde
Drug and Chemical Toxicology 1998
Aspects of Novel Sites of Regulation of the Insulin Stimulus-Secretion Coupling in Normal and Diabetic Pancreatic Islets
A Sjöholm
Endocrine 1998
Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2
MT Guillam, E Hümmler, E Schaerer, JY Wu, MJ Birnbaum, F Beermann, A Schmidt, N Dériaz, B Thorens
Nature Genetics 1997
Making sense of glucose sensing
S Efrat
Nature Genetics 1997
Advances in Molecular and Cell Biology
KJ Clemetson
Advances in Molecular and Cell Biology 1997
Human Islets of Langerhans Express Multiple Isoforms of Calcium/Calmodulin-Dependent Protein Kinase II
MA Breen, SJ Ashcroft
Biochemical and Biophysical Research Communications 1997
Metabolic Fate of Glucose in Purified Islet Cells: GLUCOSE-REGULATED ANAPLEROSIS IN β CELLS
F Schuit, AD Vos, S Farfari, K Moens, D Pipeleers, T Brun, M Prentki
The Journal of biological chemistry 1997
Role of the GLUT 2 Glucose Transporter in the Response of the L-type Pyruvate Kinase Gene to Glucose in Liver-derived Cells
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The Journal of biological chemistry 1997
Clinical Research in Diabetes and Obesity
B Draznin, R Rizza
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Expression of Glucokinase in Glucose-Unresponsive Human Fetal Pancreatic Islet-Like Cell Clusters1
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The Journal of clinical endocrinology and metabolism 1997
Glucose-Stimulated Genes and Prospects of Gene Therapy for Type I Diabetes*
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Endocrine reviews 1997
Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation
Z Ling, DG Pipeleers
Journal of Clinical Investigation 1996
Localization of the fructose 1,6-bisphosphatase at the nuclear periphery
DE Sáez, CD Figueroa, II Concha, JC Slebe
Journal of Cellular Biochemistry 1996
The glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells
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