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Citations to this article

Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men
Alireza Falahati-Nini, … , Richard Eastell, Sundeep Khosla
Alireza Falahati-Nini, … , Richard Eastell, Sundeep Khosla
Published December 15, 2000
Citation Information: J Clin Invest. 2000;106(12):1553-1560. https://doi.org/10.1172/JCI10942.
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Article Article has an altmetric score of 15

Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men

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Abstract

Young adult males who cannot produce or respond to estrogen (E) are osteopenic, suggesting that E may regulate bone turnover in men, as well as in women. Both bioavailable E and testosterone (T) decrease substantially in aging men, but it is unclear which deficiency is the more important factor contributing to the increased bone resorption and impaired bone formation that leads to their bone loss. Thus, we addressed this issue directly by eliminating endogenous T and E production in 59 elderly men (mean age 68 years), studying them first under conditions of physiologic T and E replacement and then assessing the impact on bone turnover of withdrawing both T and E, withdrawing only T, or only E, or continuing both. Bone resorption markers increased significantly in the absence of both hormones and were unchanged in men receiving both hormones. By two-factor ANOVA, E played the major role in preventing the increase in the bone resorption markers, whereas T had no significant effect. By contrast, serum osteocalcin, a bone formation marker, decreased in the absence of both hormones, and both E and T maintained osteocalcin levels. We conclude that in aging men, E is the dominant sex steroid regulating bone resorption, whereas both E and T are important in maintaining bone formation.

Authors

Alireza Falahati-Nini, B. Lawrence Riggs, Elizabeth J. Atkinson, W. Michael O’Fallon, Richard Eastell, Sundeep Khosla

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 Total
Citations: 4 10 8 12 15 8 9 11 11 21 14 12 13 17 12 10 12 10 11 3 8 5 4 1 2 243
Citation information
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Citations to this article in year 2018 (11)

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Endocrine reviews 2018
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B Filipović, B Šošić-Jurjević, V Ajdžanović, J Živanović, M Manojlović-Stojanoski, N Nestorović, N Ristić, S Trifunović, V Milošević
Journal of Anatomy 2018
The physiology of endocrine systems with ageing
AW van den Beld, JM Kaufman, MC Zillikens, SW Lamberts, JM Egan, AJ van der Lely
The Lancet Diabetes & Endocrinology 2018
Cancer Treatment and Bone Health
C Handforth, S DOronzo, R Coleman, J Brown
Calcified Tissue International 2018
Bioavailable Testosterone Is Positively Associated With Bone Mineral Density in Male Kidney Transplantation Candidates
HS Jørgensen, S Winther, M Bøttcher, EM Hauge, L Rejnmark, M Svensson, P Ivarsen
Kidney International Reports 2018
Effect of a 6-week supervised detraining period on bone metabolism markers and their association with ergometrics and components of the hypothalamic–pituitary–gonadal (HPG) axis in professional male soccer players
NE Koundourakis, N Androulakis, E Dermitzaki, M Venihaki, AN Margioris
Journal of Bone and Mineral Metabolism 2018
Chemokine-like receptor 1 deficiency leads to lower bone mass in male mice
H Zhao, D Yan, L Xiang, C Huang, J Li, X Yu, B Huang, B Wang, J Chen, T Xiao, PR, JV Zhang
Cellular and Molecular Life Sciences 2018
The effect of testosterone itself and in combination with letrozole on bone mineral density in male rats
F Saki, SR Kasaee, F Sadeghian, P Talezadeh, GH Omrani
Journal of Bone and Mineral Metabolism 2018
The Effect of Tobacco Smoking on Bone Mass: An Overview of Pathophysiologic Mechanisms
AM Al-Bashaireh, LG Haddad, M Weaver, X Chengguo, DL Kelly, S Yoon
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Bone Safety During the First Ten Years of Gender‐Affirming Hormonal Treatment in Transwomen and Transmen
CM Wiepjes, RT de Jongh, CJ de Blok, MC Vlot, P Lips, JW Twisk, M den Heijer
Journal of Bone and Mineral Research 2018
A comprehensive overview on osteoporosis and its risk factors
F Pouresmaeili, BK Dehghan, M Kamarehei, GY Meng
Therapeutics and Clinical Risk Management 2018

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