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Citations to this article

Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men
Alireza Falahati-Nini, … , Richard Eastell, Sundeep Khosla
Alireza Falahati-Nini, … , Richard Eastell, Sundeep Khosla
Published December 15, 2000
Citation Information: J Clin Invest. 2000;106(12):1553-1560. https://doi.org/10.1172/JCI10942.
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Article Article has an altmetric score of 15

Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men

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Abstract

Young adult males who cannot produce or respond to estrogen (E) are osteopenic, suggesting that E may regulate bone turnover in men, as well as in women. Both bioavailable E and testosterone (T) decrease substantially in aging men, but it is unclear which deficiency is the more important factor contributing to the increased bone resorption and impaired bone formation that leads to their bone loss. Thus, we addressed this issue directly by eliminating endogenous T and E production in 59 elderly men (mean age 68 years), studying them first under conditions of physiologic T and E replacement and then assessing the impact on bone turnover of withdrawing both T and E, withdrawing only T, or only E, or continuing both. Bone resorption markers increased significantly in the absence of both hormones and were unchanged in men receiving both hormones. By two-factor ANOVA, E played the major role in preventing the increase in the bone resorption markers, whereas T had no significant effect. By contrast, serum osteocalcin, a bone formation marker, decreased in the absence of both hormones, and both E and T maintained osteocalcin levels. We conclude that in aging men, E is the dominant sex steroid regulating bone resorption, whereas both E and T are important in maintaining bone formation.

Authors

Alireza Falahati-Nini, B. Lawrence Riggs, Elizabeth J. Atkinson, W. Michael O’Fallon, Richard Eastell, Sundeep Khosla

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 Total
Citations: 4 10 8 12 15 8 9 11 11 21 14 12 13 17 12 10 12 10 11 3 8 5 4 1 2 243
Citation information
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Citations to this article in year 2007 (11)

Title and authors Publication Year
The osteoporosis revolution marches on
LG Raisz
Journal of Orthopaedic Science 2007
Regulation of Bone Turnover by Sex Steroids in Men
A Sanyal, KA Hoey, UI Mödder, JL Lamsam, LK McCready, JM Peterson, SJ Achenbach, MJ Oursler, S Khosla
Journal of Bone and Mineral Research 2007
Expanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs)
W Gao, JT Dalton
Drug Discovery Today 2007
Androgen deprivation therapy for prostate cancer: new concepts and concerns
MR Smith
Current opinion in endocrinology, diabetes, and obesity 2007
Predictors of serum testosterone and DHEAS in African-American men
MT Haren, WA Banks, HM Perry, P Patrick, TK Malmstrom, DK Miller, JE Morley
International Journal of Andrology 2007
Bone turnover in elderly men: relationships to change in bone mineral density
TV Nguyen, C Meier, JR Center, JA Eisman, MJ Seibel
BMC musculoskeletal disorders 2007
CYP19A1 polymorphisms are associated with bone mineral density in Chinese men
X Hong, YH Hsu, H Terwedow, LM Arguelles, G Tang, X Liu, S Zhang, X Xu, X Xu
Human Genetics 2007
Biochemical assessment of bone turnover and bone fragility in men
P Szulc, JM Kaufman, PD Delmas
Osteoporosis International 2007
The effect of combined androgen blockade on bone turnover and bone mineral density in men with prostate cancer
Y Yamada, S Takahashi, T Fujimura, H Nishimatsu, A Ishikawa, H Kume, K Tomita, T Takeuchi, T Kitamura
Osteoporosis International 2007
Decreased peak bone mass is associated with a 3-bp deletion/insertion of the CYP19 intron 4 polymorphism: Preliminary data from the GOOS study
D Kastelan, Z Grubic, I Kraljevic, K Duric, I Kardum, T Dusek, K Stingl, Z Giljevic, V Kerhin-Brkljacic, E Suchanek, M Korsic
Journal of Endocrinological Investigation 2007
Estrogen metabolism modulates bone density in men.
Napoli N, Faccio R, Shrestha V, Bucchieri S, Rini GB, Armamento-Villareal R
Calcified Tissue International 2007

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