Young adult males who cannot produce or respond to estrogen (E) are osteopenic, suggesting that E may regulate bone turnover in men, as well as in women. Both bioavailable E and testosterone (T) decrease substantially in aging men, but it is unclear which deficiency is the more important factor contributing to the increased bone resorption and impaired bone formation that leads to their bone loss. Thus, we addressed this issue directly by eliminating endogenous T and E production in 59 elderly men (mean age 68 years), studying them first under conditions of physiologic T and E replacement and then assessing the impact on bone turnover of withdrawing both T and E, withdrawing only T, or only E, or continuing both. Bone resorption markers increased significantly in the absence of both hormones and were unchanged in men receiving both hormones. By two-factor ANOVA, E played the major role in preventing the increase in the bone resorption markers, whereas T had no significant effect. By contrast, serum osteocalcin, a bone formation marker, decreased in the absence of both hormones, and both E and T maintained osteocalcin levels. We conclude that in aging men, E is the dominant sex steroid regulating bone resorption, whereas both E and T are important in maintaining bone formation.
Alireza Falahati-Nini, B. Lawrence Riggs, Elizabeth J. Atkinson, W. Michael O’Fallon, Richard Eastell, Sundeep Khosla
Title and authors | Publication | Year |
---|---|---|
Growth hormone protects against ovariectomy-induced bone loss in states of low circulating insulin-like growth factor (IGF-1)
JC Fritton, KB Emerton, H Sun, Y Kawashima, W Mejia, Y Wu, CJ Rosen, D Panus, M Bouxsein, RJ Majeska, MB Schaffler, S Yakar |
Journal of Bone and Mineral Research | 2009 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Daidzein administration positively affects thyroid C cells and bone structure in orchidectomized middle-aged rats
B Filipović, B Šošić-Jurjević, V Ajdžanović, D Brkić, M Manojlović-Stojanoski, V Milošević, M Sekulić |
Osteoporosis International | 2009 |
Androgens and bone
BL Clarke, S Khosla |
Steroids | 2009 |
Estrogens as regulators of bone health in men
L Vandenput, C Ohlsson |
Nature Reviews Endocrinology | 2009 |
Osteoporosis: "A risk factor for periodontitis"
RR Koduganti, C Gorthi, PV Reddy, N Sandeep |
Journal of Indian Society of Periodontology | 2009 |
Postmenopausal women with osteoarthritis and osteoporosis show different ultrastructural characteristics of trabecular bone of the femoral head
Y Shen, ZM Zhang, SD Jiang, LS Jiang, LY Dai |
BMC musculoskeletal disorders | 2009 |
Micro-CT and mechanical evaluation of subchondral trabecular bone structure between postmenopausal women with osteoarthritis and osteoporosis
ZM Zhang, ZC Li, LS Jiang, SD Jiang, LY Dai |
Osteoporosis International | 2009 |
Osteoporosis prevention in prostate cancer patients receiving androgen ablation therapy: placebo-controlled double-blind study of estradiol and risedronate: N01C8
AE Kearns, DW Northfelt, AC Dueck, PJ Atherton, SR Dakhil, KM Rowland, J Fuloria, PJ Flynn, T Dentchev, CL Loprinzi |
Supportive Care in Cancer | 2009 |
Gonadal sex steroid status and bone health in middle-aged and elderly European men
D Vanderschueren, SR Pye, K Venken, H Borghs, J Gaytant, IT Huhtaniemi, JE Adams, KA Ward, G Bartfai, FF Casanueva, JD Finn, G Forti, A Giwercman, TS Han, K Kula, F Labrie, ME Lean, N Pendleton, M Punab, AJ Silman, FC Wu, TW O’Neill, S Boonen |
Osteoporosis International | 2009 |
Effects of Aromatase Inhibition on Bone Mineral Density and Bone Turnover in Older Men with Low Testosterone Levels
SA Burnett-Bowie, EA McKay, H Lee, BZ Leder |
The Journal of clinical endocrinology and metabolism | 2009 |
Repression of Runx2 by Androgen Receptor (AR) in Osteoblasts and Prostate Cancer Cells: AR Binds Runx2 and Abrogates Its Recruitment to DNA
SK Baniwal, O Khalid, Donna, G Buchanan, GA Coetzee, B Frenkel |
Molecular Endocrinology | 2009 |