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Citations to this article

Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men
Alireza Falahati-Nini, … , Richard Eastell, Sundeep Khosla
Alireza Falahati-Nini, … , Richard Eastell, Sundeep Khosla
Published December 15, 2000
Citation Information: J Clin Invest. 2000;106(12):1553-1560. https://doi.org/10.1172/JCI10942.
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Article Article has an altmetric score of 15

Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men

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Abstract

Young adult males who cannot produce or respond to estrogen (E) are osteopenic, suggesting that E may regulate bone turnover in men, as well as in women. Both bioavailable E and testosterone (T) decrease substantially in aging men, but it is unclear which deficiency is the more important factor contributing to the increased bone resorption and impaired bone formation that leads to their bone loss. Thus, we addressed this issue directly by eliminating endogenous T and E production in 59 elderly men (mean age 68 years), studying them first under conditions of physiologic T and E replacement and then assessing the impact on bone turnover of withdrawing both T and E, withdrawing only T, or only E, or continuing both. Bone resorption markers increased significantly in the absence of both hormones and were unchanged in men receiving both hormones. By two-factor ANOVA, E played the major role in preventing the increase in the bone resorption markers, whereas T had no significant effect. By contrast, serum osteocalcin, a bone formation marker, decreased in the absence of both hormones, and both E and T maintained osteocalcin levels. We conclude that in aging men, E is the dominant sex steroid regulating bone resorption, whereas both E and T are important in maintaining bone formation.

Authors

Alireza Falahati-Nini, B. Lawrence Riggs, Elizabeth J. Atkinson, W. Michael O’Fallon, Richard Eastell, Sundeep Khosla

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 Total
Citations: 4 10 8 12 15 8 9 11 11 21 14 12 13 17 12 10 12 10 11 3 8 5 4 1 2 243
Citation information
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Citations to this article in year 2009 (12)

Title and authors Publication Year
Growth hormone protects against ovariectomy-induced bone loss in states of low circulating insulin-like growth factor (IGF-1)
JC Fritton, KB Emerton, H Sun, Y Kawashima, W Mejia, Y Wu, CJ Rosen, D Panus, M Bouxsein, RJ Majeska, MB Schaffler, S Yakar
Journal of Bone and Mineral Research 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Daidzein administration positively affects thyroid C cells and bone structure in orchidectomized middle-aged rats
B Filipović, B Šošić-Jurjević, V Ajdžanović, D Brkić, M Manojlović-Stojanoski, V Milošević, M Sekulić
Osteoporosis International 2009
Androgens and bone
BL Clarke, S Khosla
Steroids 2009
Estrogens as regulators of bone health in men
L Vandenput, C Ohlsson
Nature Reviews Endocrinology 2009
Osteoporosis: "A risk factor for periodontitis"
RR Koduganti, C Gorthi, PV Reddy, N Sandeep
Journal of Indian Society of Periodontology 2009
Postmenopausal women with osteoarthritis and osteoporosis show different ultrastructural characteristics of trabecular bone of the femoral head
Y Shen, ZM Zhang, SD Jiang, LS Jiang, LY Dai
BMC musculoskeletal disorders 2009
Micro-CT and mechanical evaluation of subchondral trabecular bone structure between postmenopausal women with osteoarthritis and osteoporosis
ZM Zhang, ZC Li, LS Jiang, SD Jiang, LY Dai
Osteoporosis International 2009
Osteoporosis prevention in prostate cancer patients receiving androgen ablation therapy: placebo-controlled double-blind study of estradiol and risedronate: N01C8
AE Kearns, DW Northfelt, AC Dueck, PJ Atherton, SR Dakhil, KM Rowland, J Fuloria, PJ Flynn, T Dentchev, CL Loprinzi
Supportive Care in Cancer 2009
Gonadal sex steroid status and bone health in middle-aged and elderly European men
D Vanderschueren, SR Pye, K Venken, H Borghs, J Gaytant, IT Huhtaniemi, JE Adams, KA Ward, G Bartfai, FF Casanueva, JD Finn, G Forti, A Giwercman, TS Han, K Kula, F Labrie, ME Lean, N Pendleton, M Punab, AJ Silman, FC Wu, TW O’Neill, S Boonen
Osteoporosis International 2009
Effects of Aromatase Inhibition on Bone Mineral Density and Bone Turnover in Older Men with Low Testosterone Levels
SA Burnett-Bowie, EA McKay, H Lee, BZ Leder
The Journal of clinical endocrinology and metabolism 2009
Repression of Runx2 by Androgen Receptor (AR) in Osteoblasts and Prostate Cancer Cells: AR Binds Runx2 and Abrogates Its Recruitment to DNA
SK Baniwal, O Khalid, Donna, G Buchanan, GA Coetzee, B Frenkel
Molecular Endocrinology 2009

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