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Citations to this article

Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men
Alireza Falahati-Nini, … , Richard Eastell, Sundeep Khosla
Alireza Falahati-Nini, … , Richard Eastell, Sundeep Khosla
Published December 15, 2000
Citation Information: J Clin Invest. 2000;106(12):1553-1560. https://doi.org/10.1172/JCI10942.
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Article Article has an altmetric score of 15

Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men

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Abstract

Young adult males who cannot produce or respond to estrogen (E) are osteopenic, suggesting that E may regulate bone turnover in men, as well as in women. Both bioavailable E and testosterone (T) decrease substantially in aging men, but it is unclear which deficiency is the more important factor contributing to the increased bone resorption and impaired bone formation that leads to their bone loss. Thus, we addressed this issue directly by eliminating endogenous T and E production in 59 elderly men (mean age 68 years), studying them first under conditions of physiologic T and E replacement and then assessing the impact on bone turnover of withdrawing both T and E, withdrawing only T, or only E, or continuing both. Bone resorption markers increased significantly in the absence of both hormones and were unchanged in men receiving both hormones. By two-factor ANOVA, E played the major role in preventing the increase in the bone resorption markers, whereas T had no significant effect. By contrast, serum osteocalcin, a bone formation marker, decreased in the absence of both hormones, and both E and T maintained osteocalcin levels. We conclude that in aging men, E is the dominant sex steroid regulating bone resorption, whereas both E and T are important in maintaining bone formation.

Authors

Alireza Falahati-Nini, B. Lawrence Riggs, Elizabeth J. Atkinson, W. Michael O’Fallon, Richard Eastell, Sundeep Khosla

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 Total
Citations: 4 10 8 12 15 8 9 11 11 21 14 12 13 17 12 10 12 10 11 3 8 5 4 1 2 243
Citation information
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Citations to this article in year 2015 (14)

Title and authors Publication Year
Time and dose-dependent effects of Labisia pumila on the bone strength of postmenopausal osteoporosis rat model
NM Effendy, S Abdullah, MF Yunoh, AN Shuid
BMC complementary and alternative medicine 2015
The Endocrine Role of Estrogens on Human Male Skeleton
V Rochira, E Kara, C Carani
International Journal of Endocrinology 2015
Effects of Deletion of ERα in Osteoblast-Lineage Cells on Bone Mass and Adaptation to Mechanical Loading Differ in Female and Male Mice: EFFECTS OF DELETION OF ERα ON BONE MASS
KM Melville, NH Kelly, G Surita, DB Buchalter, JC Schimenti, RP Main, FP Ross, MC van der Meulen
Journal of Bone and Mineral Research 2015
New Insights Into Androgen and Estrogen Receptor Regulation of the Male Skeleton: AR AND ER REGULATION OF BONE METABOLISM
S Khosla
Journal of Bone and Mineral Research 2015
High aromatase activity in hypogonadal men is associated with higher spine bone mineral density, increased truncal fat and reduced lean mass
LE Aguirre, G Colleluori, KE Fowler, IZ Jan, K Villareal, C Qualls, D Robbins, DT Villareal, R Armamento-Villareal
European Journal of Endocrinology 2015
Osteoporosis Is Associated With High Risk for Coronary Heart Disease: A Population-Based Cohort Study
SJ Chen, CS Lin, CL Lin, CH Kao
Medicine 2015
Thyrotropin serum levels are differentially associated with biochemical markers of bone turnover and stiffness in women and men: results from the SHIP cohorts
E Tsourdi, H Wallaschofski, M Rauner, M Nauck, M Pietzner, R Rettig, T Ittermann, H Völzke, U Völker, LC Hofbauer, A Hannemann
Osteoporosis International 2015
Testosterone and Adult Male Bone: Actions Independent of 5α-Reductase and Aromatase
JF Yarrow, TJ Wronski, SE Borst
Exercise and Sport Sciences Reviews 2015
Blood Cadmium Is Associated with Osteoporosis in Obese Males but Not in Non-Obese Males: The Korea National Health and Nutrition Examination Survey 2008–2011
WJ Choi, SH Han
International journal of environmental research and public health 2015
Effects of aromatase inhibition vs. testosterone in older men with low testosterone: randomized-controlled trial
JP Dias, D Melvin, EM Simonsick, O Carlson, MD Shardell, L Ferrucci, CW Chia, S Basaria, JM Egan
Andrologia 2015
An update on the role of testosterone replacement therapy in the management of hypogonadism
G Hackett
Therapeutic advances in urology 2015
Effects of electroacupuncture at GB points on markers of osteoporosis and bodyweight in ovariectomised rats
HD Wang, Z Chen, I Inoue, SJ Fu, XL Shi, L Tang, FZ Zhang, Y Jiang, H Jiang
Acupuncture in Medicine 2015
Injection of testosterone may be safer and more effective than transdermal administration for combating loss of muscle and bone in older men
SE Borst, JF Yarrow
American journal of physiology. Endocrinology and metabolism 2015
Biological and clinical effects of abiraterone on anti-resorptive and anabolic activity in bone microenvironment.
Iuliani M, Pantano F, Buttigliero C, Fioramonti M, Bertaglia V, Vincenzi B, Zoccoli A, Ribelli G, Tucci M, Vignani F, Berruti A, Scagliotti GV, Tonini G, Santini D
Oncotarget 2015

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