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Abstract
Canine marrow erythroid colony growth is enhanced by agents linked to the adenyl cyclase/cyclic AMP (cAMP) system, including cAMP, a phosphodieterase inhibitor (RO-20-1724), cholera enterotoxin, and beta-adrenergic agonists. The adrenergic effect is mediated by receptors having beta2-subspecificity. These receptors are distinct from putative receptors for erythropoietin and those acted upon by cholera enterotoxin. In addition, the population of cells most responsive to beta-agonists is distinct from the majority of erythropoientin-responsive cells, perhaps representing a subpopulation of this class of cell. This demonstration of an adenyl cyclase-linked mechanism regulating mammalian erythroid colony growth provides a model for the modulation by other hormones or small molecules of in vitro and, perhaps, in vivo erythropoiesis.
Authors
J E Brown, J W Adamson
Total citations by year
Citations to this article in year 2015 (2)
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|---|---|---|
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Z Sternberg |
Autoimmunity Reviews | 2015 |
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Modulation of Bleomycin-Induced Lung Fibrosis by Pegylated Hyaluronidase and Dopamine Receptor Antagonist in Mice
EG Skurikhin, OV Pershina, AM Reztsova, NN Ermakova, ES Khmelevskaya, VA Krupin, IE Stepanova, AV Artamonov, AA Bekarev, PG Madonov, AM Dygai, W Shi |
PloS one | 2015 |
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