Citations to this article
Abstract
Canine marrow erythroid colony growth is enhanced by agents linked to the adenyl cyclase/cyclic AMP (cAMP) system, including cAMP, a phosphodieterase inhibitor (RO-20-1724), cholera enterotoxin, and beta-adrenergic agonists. The adrenergic effect is mediated by receptors having beta2-subspecificity. These receptors are distinct from putative receptors for erythropoietin and those acted upon by cholera enterotoxin. In addition, the population of cells most responsive to beta-agonists is distinct from the majority of erythropoientin-responsive cells, perhaps representing a subpopulation of this class of cell. This demonstration of an adenyl cyclase-linked mechanism regulating mammalian erythroid colony growth provides a model for the modulation by other hormones or small molecules of in vitro and, perhaps, in vivo erythropoiesis.
Authors
J E Brown, J W Adamson
Total citations by year
Citations to this article in year 2009 (2)
| Title and authors | Publication | Year |
|---|---|---|
|
The α1-adrenergic receptor antagonists, benoxathian and prazosin, induce apoptosis and a switch towards megakaryocytic differentiation in human erythroleukemia cells
R Fuchs, I Stelzer, HS Haas, G Leitinger, K Schauenstein, A Sadjak |
Annals of Hematology | 2009 |
|
Sympathetic Overstimulation During Critical Illness: Adverse Effects of Adrenergic Stress
MW Dünser, WR Hasibeder |
Journal of Intensive Care Medicine | 2009 |
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