Citations to this article
Abstract
Canine marrow erythroid colony growth is enhanced by agents linked to the adenyl cyclase/cyclic AMP (cAMP) system, including cAMP, a phosphodieterase inhibitor (RO-20-1724), cholera enterotoxin, and beta-adrenergic agonists. The adrenergic effect is mediated by receptors having beta2-subspecificity. These receptors are distinct from putative receptors for erythropoietin and those acted upon by cholera enterotoxin. In addition, the population of cells most responsive to beta-agonists is distinct from the majority of erythropoientin-responsive cells, perhaps representing a subpopulation of this class of cell. This demonstration of an adenyl cyclase-linked mechanism regulating mammalian erythroid colony growth provides a model for the modulation by other hormones or small molecules of in vitro and, perhaps, in vivo erythropoiesis.
Authors
J E Brown, J W Adamson
Total citations by year
Citations to this article in year 2011 (3)
| Title and authors | Publication | Year |
|---|---|---|
|
Suppression of erythropoiesis in patients with chronic heart failure and anaemia of unknown origin: evidence of an immune basis
DO Okonko, SB Marley, SD Anker, PA Poole-Wilson, MY Gordon |
International Journal of Cardiology | 2011 |
|
α1-adrenergic drugs modulate differentiation and cell death of human erythroleukemia cells through non adrenergic mechanism
R Fuchs, E Schraml, G Leitinger, I Stelzer, N Allard, HS Haas, K Schauenstein, A Sadjak |
Experimental Cell Research | 2011 |
|
Red cell distribution width and risk for first hospitalization due to heart failure: a population-based cohort study
Y Borne, JG Smith, O Melander, B Hedblad, G Engstrom |
European Journal of Heart Failure | 2011 |
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