Citations to this article
Abstract
Canine marrow erythroid colony growth is enhanced by agents linked to the adenyl cyclase/cyclic AMP (cAMP) system, including cAMP, a phosphodieterase inhibitor (RO-20-1724), cholera enterotoxin, and beta-adrenergic agonists. The adrenergic effect is mediated by receptors having beta2-subspecificity. These receptors are distinct from putative receptors for erythropoietin and those acted upon by cholera enterotoxin. In addition, the population of cells most responsive to beta-agonists is distinct from the majority of erythropoientin-responsive cells, perhaps representing a subpopulation of this class of cell. This demonstration of an adenyl cyclase-linked mechanism regulating mammalian erythroid colony growth provides a model for the modulation by other hormones or small molecules of in vitro and, perhaps, in vivo erythropoiesis.
Authors
J E Brown, J W Adamson
Total citations by year
Citations to this article in year 2013 (3)
| Title and authors | Publication | Year |
|---|---|---|
|
Micronucleus induction in the bone marrow of rats by pharmacological mechanisms. II: long-acting beta-2 agonism
I Ponten, P Mutch, DJ Nicholls, A Saad, CD Pohl, A Young, C Fred, MR O'Donovan, P Aberg |
Mutagenesis | 2013 |
|
Interpreting Stress Responses during Routine Toxicity Studies: A Review of the Biology, Impact, and Assessment
NE Everds, PW Snyder, KL Bailey, B Bolon, DM Creasy, GL Foley, TJ Rosol, T Sellers |
Toxicologic pathology | 2013 |
|
Relation Between Red Cell Distribution Width and Severity of Coronary Artery Disease in Patients With Acute Myocardial Infarction
F Akın, N Köse, B Ayça, F Katkat, M Duran, OK Uysal, H Arinc |
Angiology | 2013 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)