Citations to this article
Citation Information: J Clin Invest. 1976;57(6):1652-1659. https://doi.org/10.1172/JCI108436.
Abstract
Hemoglobin A1c, the most abundant minor hemoglobin component in human erythrocytes, is formed by the condensation of glucose with the N-terminal amino groups of the beta-chains of Hb A. The biosynthesis of this glycosylated hemoglobin was studied in vitro by incubating suspensions of reticulocytes and bone marrow cells with [3H]leucine or 59Fe-bound transferrin. In all experiments, the specific activity of Hb A1c was significantly lower than that of Hb A, suggesting that the formation of Hb A1c is a posttranslational modification. The formation of Hb A1c in vivo was determined in two individuals who were given an infusion of 59Fe-labeled transferrin. As expected, the specific activity of Hb A rose promptly to a maximum during the 1st week and remained nearly constant thereafter. In contrast, the specific activity of Hb A1c and also of Hbs A1a and A1b rose slowly, reaching that of Hb A by about day 60. These results indicate that Hb A1c is slowly formed during the 120-day life-span of the erythrocyte, probably by a nonenzymatic process. Patients with shortened erythrocyte life-span due to hemolysis had markedly decreased levels of Hb A1c.
Authors
H F Bunn, D N Haney, S Kamin, K H Gabbay, P M Gallop
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BA Smith, CR Mottishaw, AJ Hendricks, J Mitchell, S Becker, PS Ropski, B Park, M Finkbeiner-Caufield, B Garay-Nontol, RW Holman, KJ Rodnick, C Antonescu |
Cogent Biology | 2018 |
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AT Kuna, K Dukic, NN Gabaj, M Miler, I Vukasovic, S Langer, AM Simundic, N Vrkic |
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Médecine des Maladies Métaboliques | 2018 |
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The application of simple metrics in the assessment of glycaemic variability
L Monnier, C Colette, DR Owens |
Diabetes & Metabolism | 2018 |
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La variabilité glycémique : l’évaluation de son impact passe par des index de mesure et des recommandations simples
L Monnier, C Colette, DR Owens |
Médecine des Maladies Métaboliques | 2018 |
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Investigating the Reliability of HbA1c Monitoring for Blood Glucose Control During Late Pregnancy in Patients with Gestational Diabetes Mellitus (GDM) with and without β-Thalassemia Minor
X Zhang, Y Xiao, Y Fan |
Diabetes Therapy | 2018 |
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Glycated haemoglobin (HbA 1c ) for postmortem diagnosis of diabetes
D Lepik, M Tõnisson, A Kuudeberg, M Väli |
Forensic Sciences Research | 2018 |
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Glycosylated haemoglobin values of alloxan-induced diabetic rats treated with graded doses of Cussonia arborea extract
PE Aba, IU Asuzu |
Journal of Applied Animal Research | 2018 |
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BACTERIOLOGICAL PROFILE OF DIABETIC FOOT ULCERS WITH REFERENCE TO HbA1c LEVELS
S Ansar, A Dastagir |
2018 |
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