Citations to this article
Citation Information: J Clin Invest. 1976;57(6):1652-1659. https://doi.org/10.1172/JCI108436.
Abstract
Hemoglobin A1c, the most abundant minor hemoglobin component in human erythrocytes, is formed by the condensation of glucose with the N-terminal amino groups of the beta-chains of Hb A. The biosynthesis of this glycosylated hemoglobin was studied in vitro by incubating suspensions of reticulocytes and bone marrow cells with [3H]leucine or 59Fe-bound transferrin. In all experiments, the specific activity of Hb A1c was significantly lower than that of Hb A, suggesting that the formation of Hb A1c is a posttranslational modification. The formation of Hb A1c in vivo was determined in two individuals who were given an infusion of 59Fe-labeled transferrin. As expected, the specific activity of Hb A rose promptly to a maximum during the 1st week and remained nearly constant thereafter. In contrast, the specific activity of Hb A1c and also of Hbs A1a and A1b rose slowly, reaching that of Hb A by about day 60. These results indicate that Hb A1c is slowly formed during the 120-day life-span of the erythrocyte, probably by a nonenzymatic process. Patients with shortened erythrocyte life-span due to hemolysis had markedly decreased levels of Hb A1c.
Authors
H F Bunn, D N Haney, S Kamin, K H Gabbay, P M Gallop
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Citations to this article in year 2013 (8)
| Title and authors | Publication | Year |
|---|---|---|
|
A semi-mechanistic model of the relationship between average glucose and HbA1c in healthy and diabetic subjects
R Lledó-García, NA Mazer, MO Karlsson |
Journal of Pharmacokinetics and Pharmacodynamics | 2013 |
|
Pitfalls in Hemoglobin A1c Measurement: When Results may be Misleading
MS Radin |
Journal of General Internal Medicine | 2013 |
|
Impact of glutathione-HbA1c on HbA1c measurement in diabetes diagnosis via array isoelectric focusing, liquid chromatography, mass spectrometry and ELISA
S Li, CG Guo, L Chen, XY Yin, YX Wu, LY Fan, HZ Fan, CX Cao |
Talanta | 2013 |
|
Practicing biochemistry without a license
HF Bunn |
The Journal of biological chemistry | 2013 |
|
Prevalence of Diabetes and Prediabetes according to Fasting Plasma Glucose and HbA1c
JY Jeon, SH Ko, HS Kwon, NH Kim, JH Kim, CS Kim, KH Song, JC Won, S Lim, SH Choi, MJ Jang, Y Kim, K Oh, DJ Kim, BY Cha, |
Diabetes & Metabolism Journal | 2013 |
|
Alterations in HbA1c resulting from the donation of autologous blood for elective surgery in patients with diabetes mellitus
T Sugimoto, M Hashimoto, I Hayakawa, O Tokuno, T Ogino, M Okuno, N Hayashi, S Kawano, D Sugiyama, H Minami |
Blood Transfusion | 2013 |
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Red blood cell subpopulations in freshly drawn blood: application of proteomics and metabolomics to a decades-long biological issue
A D’Alessandro, B Blasi, GM D’Amici, C Marrocco, L Zolla |
Blood Transfusion | 2013 |
|
HbA 1c : changing units, changing minds – mission accomplished?
D Levy |
The British Journal of Diabetes & Vascular Disease | 2013 |
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