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Citations to this article

The biosynthesis of human hemoglobin A1c. Slow glycosylation of hemoglobin in vivo.
H F Bunn, … , K H Gabbay, P M Gallop
H F Bunn, … , K H Gabbay, P M Gallop
Published June 1, 1976
Citation Information: J Clin Invest. 1976;57(6):1652-1659. https://doi.org/10.1172/JCI108436.
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Research Article Article has an altmetric score of 19

The biosynthesis of human hemoglobin A1c. Slow glycosylation of hemoglobin in vivo.

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Abstract

Hemoglobin A1c, the most abundant minor hemoglobin component in human erythrocytes, is formed by the condensation of glucose with the N-terminal amino groups of the beta-chains of Hb A. The biosynthesis of this glycosylated hemoglobin was studied in vitro by incubating suspensions of reticulocytes and bone marrow cells with [3H]leucine or 59Fe-bound transferrin. In all experiments, the specific activity of Hb A1c was significantly lower than that of Hb A, suggesting that the formation of Hb A1c is a posttranslational modification. The formation of Hb A1c in vivo was determined in two individuals who were given an infusion of 59Fe-labeled transferrin. As expected, the specific activity of Hb A rose promptly to a maximum during the 1st week and remained nearly constant thereafter. In contrast, the specific activity of Hb A1c and also of Hbs A1a and A1b rose slowly, reaching that of Hb A by about day 60. These results indicate that Hb A1c is slowly formed during the 120-day life-span of the erythrocyte, probably by a nonenzymatic process. Patients with shortened erythrocyte life-span due to hemolysis had markedly decreased levels of Hb A1c.

Authors

H F Bunn, D N Haney, S Kamin, K H Gabbay, P M Gallop

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1982 1981 1980 1979 1978 1977 1976 1974 Total
Citations: 1 2 1 5 10 7 11 11 10 10 14 13 8 8 12 5 7 11 7 11 8 7 7 4 1 1 3 6 7 7 1 3 3 5 3 7 6 3 6 8 8 13 20 21 31 21 22 16 3 3 1 419
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Citations to this article in year 2015 (14)

Title and authors Publication Year
The Optimal Cutoff Value of Glycated Hemoglobin for Detection of Diabetic Retinopathy
JM Kim, DJ Kim
Diabetes & Metabolism Journal 2015
The Diagnosis of Posttransplantation Diabetes Mellitus: Meeting the Challenges
J Werzowa, M Hecking, M Haidinger, D Döller, A Sharif, A Tura, MD Säemann
Current Diabetes Reports 2015
What can we learn from variation of red cell size distribution?
HF Bunn
American Journal of Hematology 2015
Glycemic Variability: Assessing Glycemia Differently and the Implications for Dietary Management of Diabetes
J Tay, CH Thompson, GD Brinkworth
Annual Review of Nutrition 2015
Biomarkers and Biosensors
A Sadana, N Sadana
Biomarkers and Biosensors 2015
An Overview of Glycemic Goals and Medications Used to Manage Type 2 Diabetes:
MK Grams, S Dinsmore, J Goldman-Levine, RR Couris
Nutrition Today 2015
HbA1c: A Useful Screening Test for Gestational Diabetes Mellitus
S Soumya, M Rohilla, S Chopra, S Dutta, A Bhansali, G Parthan, P Dutta
Diabetes Technology & Therapeutics 2015
Correlation of serum chromium, zinc, magnesium and SOD levels with HbA1c in type 2 diabetes: A cross sectional analysis
Z Doddigarla, I Parwez, J Ahmad
Diabetes and Metabolic Syndrome: Clinical Research and Reviews 2015
Luminol chemiluminescence biosensor for glycated hemoglobin (HbA1c) in Human Blood samples
KS Ahn, JH Lee, JM Park, HN Choi, WY Lee
Biosensors and Bioelectronics 2015
Glycated albumin is a more accurate glycaemic indicator than haemoglobin A 1c in diabetic patients with pre-dialysis chronic kidney disease: Glycated albumin and HbA 1c in CKD
IY Kim, MJ Kim, DW Lee, SB Lee, H Rhee, SH Song, EY Seong, IS Kwak
Nephrology 2015
A high-throughput method for measurement of glycohemoglobin in blood samples utilizing laser-accelerated proteolysis and MALDI-TOF MS
L Li, W Zang, X Zhang
Analytical and Bioanalytical Chemistry 2015
Physiologic Concepts That May Revise the Interpretation and Implications of HbA1C in Clinical Medicine: An American Perspective
EP Smith, RM Cohen
Journal of diabetes science and technology 2015
Advancing the Development of Glycated Protein Biosensing Technology: Next-Generation Sensing Molecules
M Kameya, A Sakaguchi-Mikami, S Ferri, W Tsugawa, K Sode
Journal of diabetes science and technology 2015
Effects of thyroid hormone replacement on glycated hemoglobin levels in non diabetic subjects with overt hypothyroidism
S Anantarapu, S Vaikkakara, A Sachan, BV Phaneendra, MM Suchitra, AP Reddy, S Epuri, A Mukka, D Vemvakam
Archives of Endocrinology and Metabolism 2015

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