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Hans D. Ochs, … , Starkey D. Davis, Ralph J. Wedgwood
Published December 1, 1971
Citation Information: J Clin Invest. 1971;50(12):2559-2568. https://doi.org/10.1172/JCI106756.
Citation Information: J Clin Invest. 1971;50(12):2559-2568. https://doi.org/10.1172/JCI106756.
Abstract
Immunologic responses to bacteriophage ϕX 174 were studied in 26 patients with immunodeficiency diseases. In eight cases of infantile X-linked agammaglobulinemia, there was prolonged circulation of phage and no detectable antibody response. The remaining 18 patients cleared phage normally and produced antibodies. 10 of these patients made only IgM antibody in spite of repeated immunization; all of these have recurrent respiratory tract infections and require treatment with gamma globulin and antibiotics. Eight patients made both IgM and IgG antibody; they experience either milder or no infections, and only one requires treatment with gamma globulin.
Authors
Hans D. Ochs, Starkey D. Davis, Ralph J. Wedgwood
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Citation information
Citations to this article in year 2020 (6)
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Frontiers in immunology | 2020 |
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The Rationale for Using Bacteriophage to Treat and Prevent Periprosthetic Joint Infections
JD Belleghem, R Manasherob, R Miȩdzybrodzki, P Rogóż, A Górski, GA Suh, PL Bollyky, DF Amanatullah |
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Natural and Induced Antibodies Against Phages in Humans: Induction Kinetics and Immunogenicity for Structural Proteins of PB1-Related Phages
K Hodyra-Stefaniak, Z Kaźmierczak, J Majewska, S Sillankorva, P Miernikiewicz, R Międzybrodzki, A Górski, J Azeredo, R Lavigne, D Lecion, S Nowak, M Harhala, P Waśko, B Owczarek, K Gembara, K Dąbrowska |
2020 | |
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R Ameratunga, C Allan, ST Woon |
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Class switch recombination defects: impact on b cell maturation and antibody responses
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