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Hans D. Ochs, … , Starkey D. Davis, Ralph J. Wedgwood
Published December 1, 1971
Citation Information: J Clin Invest. 1971;50(12):2559-2568. https://doi.org/10.1172/JCI106756.
Citation Information: J Clin Invest. 1971;50(12):2559-2568. https://doi.org/10.1172/JCI106756.
Abstract
Immunologic responses to bacteriophage ϕX 174 were studied in 26 patients with immunodeficiency diseases. In eight cases of infantile X-linked agammaglobulinemia, there was prolonged circulation of phage and no detectable antibody response. The remaining 18 patients cleared phage normally and produced antibodies. 10 of these patients made only IgM antibody in spite of repeated immunization; all of these have recurrent respiratory tract infections and require treatment with gamma globulin and antibiotics. Eight patients made both IgM and IgG antibody; they experience either milder or no infections, and only one requires treatment with gamma globulin.
Authors
Hans D. Ochs, Starkey D. Davis, Ralph J. Wedgwood
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Citation information
Citations to this article in year 2014 (7)
| Title and authors | Publication | Year |
|---|---|---|
|
Comparison of Diagnostic Criteria for Common Variable Immunodeficiency Disorder
R Ameratunga, M Brewerton, C Slade, A Jordan, D Gillis, R Steele, W Koopmans, ST Woon |
Frontiers in immunology | 2014 |
|
Laboratory Diagnosis of Primary Immunodeficiencies
BA Locke, T Dasu, JW Verbsky |
Clinical Reviews in Allergy & Immunology | 2014 |
|
The T-cell-dependent antibody response assay in nonclinical studies of pharmaceuticals and chemicals: Study design, data analysis, interpretation
H Lebrec, B Molinier, D Boverhof, M Collinge, W Freebern, K Henson, DT Mytych, HD Ochs, R Wange, Y Yang, L Zhou, J Arrington, MS Christin-Piché, J Shenton |
Regulatory Toxicology and Pharmacology | 2014 |
|
Diagnostic Immunization with Bacteriophage ΦX 174 in Patients with Common Variable Immunodeficiency/Hypogammaglobulinemia
LL Smith, R Buckley, P Lugar |
Frontiers in immunology | 2014 |
|
Isolation of a Bacteriophage and Its Depolymerase Specific for K1 Capsule of Klebsiella pneumoniae: Implication in Typing and Treatment
TL Lin, PF Hsieh, YT Huang, WC Lee, YT Tsai, PA Su, YJ Pan, CR Hsu, MC Wu, JT Wang |
The Journal of Infectious Diseases | 2014 |
|
Adventitious agents in viral vaccines: Lessons learned from 4 case studies
J Petricciani, R Sheets, E Griffiths, I Knezevic |
Biologicals | 2014 |
|
Primary Immunodeficiency Disorders
M Berger, ER Stiehm |
2014 |
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