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Hans D. Ochs, … , Starkey D. Davis, Ralph J. Wedgwood
Published December 1, 1971
Citation Information: J Clin Invest. 1971;50(12):2559-2568. https://doi.org/10.1172/JCI106756.
Citation Information: J Clin Invest. 1971;50(12):2559-2568. https://doi.org/10.1172/JCI106756.
Abstract
Immunologic responses to bacteriophage ϕX 174 were studied in 26 patients with immunodeficiency diseases. In eight cases of infantile X-linked agammaglobulinemia, there was prolonged circulation of phage and no detectable antibody response. The remaining 18 patients cleared phage normally and produced antibodies. 10 of these patients made only IgM antibody in spite of repeated immunization; all of these have recurrent respiratory tract infections and require treatment with gamma globulin and antibiotics. Eight patients made both IgM and IgG antibody; they experience either milder or no infections, and only one requires treatment with gamma globulin.
Authors
Hans D. Ochs, Starkey D. Davis, Ralph J. Wedgwood
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Citation information
Citations to this article in year 2009 (8)
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|---|---|---|
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Biological Gene Delivery Vehicles: Beyond Viral Vectors
Y Seow, MJ Wood |
Molecular Therapy | 2009 |
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Immunologic reconstitution during PEG-ADA therapy in an unusual mosaic ADA deficient patient
P Liu, I Santisteban, LM Burroughs, HD Ochs, TR Torgerson, MS Hershfield, DJ Rawlings, AM Scharenberg |
Clinical Immunology | 2009 |
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Comèl-Netherton syndrome defined as primary immunodeficiency
ED Renner, D Hartl, S Rylaarsdam, ML Young, L Monaco-Shawver, G Kleiner, ML Markert, ER Stiehm, BH Belohradsky, MP Upton, TR Torgerson, JS Orange, HD Ochs |
Journal of Allergy and Clinical Immunology | 2009 |
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Phage therapy
JN Housby, NH Mann |
Drug Discovery Today | 2009 |
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The role of costimulation in antibody deficiencies: ICOS and common variable immunodeficiency
PF Yong, U Salzer, B Grimbacher |
Immunological Reviews | 2009 |
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PERSISTENT ANTIBODY DEPLETION AFTER RITUXIMAB IN THREE CHILDREN WITH AUTOIMMUNE CYTOPENIAS
MM Adeli, BH Eichner, C Thornburg, L Williams |
Pediatric Hematology-Oncology | 2009 |
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Bacteriophage biocontrol in animals and meat products
RJ Atterbury |
Microbial Biotechnology | 2009 |
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Rituximab, B-lymphocyte depletion, and preservation of beta-cell function.
Pescovitz MD, Greenbaum CJ, Krause-Steinrauf H, Becker DJ, Gitelman SE, Goland R, Gottlieb PA, Marks JB, McGee PF, Moran AM, Raskin P, Rodriguez H, Schatz DA, Wherrett D, Wilson DM, Lachin JM, Skyler JS |
The New England journal of medicine | 2009 |
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