Immune responses take place throughout the body and require the migration of particular subsets of immune cells to precise locations. Brede et al. report the development of a microscopy...
Published November 12, 2012

Integrins are proteins that connect the extracellular matrix to the cytoskeleton, mediating the attachment of cells to the surrounding tissue. The integrin α3β1, encoded by the gene ITGA3, is...
Published November 1, 2012

Hypoxic pulmonary vasoconstriction (HPV) is a physiological mechanism by which the pulmonary arteries redirect blood flow from a hypoxic region of the lungs to a region that is oxygen rich....
Published October 24, 2012

Psoriasis is a chronic inflammatory skin disorder that affects approximately 2% of the world’s population. A group of inflammatory molecules known as interleukins activate an immune response...
Published October 15, 2012

The cells in the tumor microenvironment play a critical role in growth and metastasis. In breast cancer, the surrounding adipocytes provide factors that drive tumor progression. Col6 is a...
Published October 8, 2012

Macrophages drive the formation of atherosclerotic plaques by stimulating inflammation and the accumulation of LDL. Nazari-Jahantigh et al. investigated how microRNAs influence the behavior of...
Published October 8, 2012

A complex genetic regulatory network mediates regeneration in adult skeletal muscles. In this issue of the JCI, Hong et al. report that HEXIM1, a protein that regulates gene transcription,...
Published October 1, 2012

The cornea is under constant threat of attack by microorganisms. The layer of cells that line the cornea, known as epithelial cells, are the first line of defense against these pathogens, but...
Published September 24, 2012

The heart is one of the first organs to form during vertebrate development and mutations in the genes that govern heart development are associated with congenital heart disease in humans. In...
Published September 17, 2012

Plasmodium falciparum is the most deadly human malaria parasite, causing more than 800,000 deaths per year. After the parasite enters the blood stream, it travels to the liver, where it...
Published September 10, 2012