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microRNA-210 skews T cell subsets to promote psoriatic inflammation
The cause of imbalances in T cell subsets-- considered a key component of psoriasis pathogenesis-- remains unclear. A study published in the JCI implicates overexpression of miR-210 in biasing T cell differentiation toward pathogenic Th1 and Th17 cells.
Published May 23, 2018
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Disruption of PBX transcription factors induces lung-intrinsic neonatal pulmonary hypertension
This week in the JCI, a study from Xin Sun's lab at UCSD reveals that PBX transcription factors play a crucial role in infant lung development and function...
Published December 18, 2017
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Glutamate clearance deficits underlie hyperactive-impulsive behaviors in an ADHD model
Recently in the JCI, a study led by Lize Xiong and Yan Li evaluated non-dopaminergic mechanisms contributing to ADHD-like behavior in NDRG2-deficient mice.
Published October 31, 2017
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An essential role for YAP/TAZ in developmental and pathogenic angiogenesis
A study from Gou Young Koh's lab at the Korea Advanced Institute of Science and Technology reveals that YAP/TAZ coordinates angiogenesis and vascular remodeling in the brain and retina...
Published August 14, 2017
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Non-classical monocytes contribute to treatment resistance against anti-VEGF cancer therapies
Jung et al. describe how immunosuppressive effects of non-classical Ly6C-low monocytes contribute to resistance against anti-VEGF therapies in mouse models of colorectal cancer.
Published July 10, 2017
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Ubiquitin ligase RNF146 influences osteoblast proliferation by regulating β-catenin signaling
A study by Matsumoto et al. links regulation of Wnt/β-catenin signaling by the ubiquitin ligase RNF146 as a fate-determining pathway in osteoblastogenesis...
Published June 5, 2017
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Lymphatic vessel valves require RASA1 for development and function
Research led by Philip King at University of Michigan Medical School reports that RASA1 activity is essential for proper functioning and development of lymphatic vessel valves...
Published May 22, 2017
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Keratin 15+ progenitors maintain rapid renewal and regeneration in esophageal epithelium
Giroux et al. determined that expression of the keratin 15 promoter distinguishes a distinct basal stem cell population in the esophageal epithelium that is capable of self-renewal, proliferation, and differentiation into squamous-lineage cells...
Published May 8, 2017
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Expression of GPR182 in crypt cells is a switch for intestinal proliferation
This week in the JCI, work led by Kathleen Caron at the University of North Carolina identifies a role for the orphan receptor GPR182 in regulating intestinal proliferation.
Published January 17, 2017
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Live-imaging shows how aminoglycoside antibiotics damage hair cells
David Raible’s lab at the University of Washington imaged fluorescently-labeled aminoglycosides in the hair cells of live zebrafish and evaluated the transit of the antibiotic from the cytosol into lysosomes.
Published December 19, 2016
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