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An essential role for YAP/TAZ in developmental and pathogenic angiogenesis
A study from Gou Young Koh's lab at the Korea Advanced Institute of Science and Technology reveals that YAP/TAZ coordinates angiogenesis and vascular remodeling in the brain and retina...
Published August 14, 2017
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Non-classical monocytes contribute to treatment resistance against anti-VEGF cancer therapies
Jung et al. describe how immunosuppressive effects of non-classical Ly6C-low monocytes contribute to resistance against anti-VEGF therapies in mouse models of colorectal cancer.
Published July 10, 2017
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Ubiquitin ligase RNF146 influences osteoblast proliferation by regulating β-catenin signaling
A study by Matsumoto et al. links regulation of Wnt/β-catenin signaling by the ubiquitin ligase RNF146 as a fate-determining pathway in osteoblastogenesis...
Published June 5, 2017
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Lymphatic vessel valves require RASA1 for development and function
Research led by Philip King at University of Michigan Medical School reports that RASA1 activity is essential for proper functioning and development of lymphatic vessel valves...
Published May 22, 2017
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Keratin 15+ progenitors maintain rapid renewal and regeneration in esophageal epithelium
Giroux et al. determined that expression of the keratin 15 promoter distinguishes a distinct basal stem cell population in the esophageal epithelium that is capable of self-renewal, proliferation, and differentiation into squamous-lineage cells...
Published May 8, 2017
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Expression of GPR182 in crypt cells is a switch for intestinal proliferation
This week in the JCI, work led by Kathleen Caron at the University of North Carolina identifies a role for the orphan receptor GPR182 in regulating intestinal proliferation.
Published January 17, 2017
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Live-imaging shows how aminoglycoside antibiotics damage hair cells
David Raible’s lab at the University of Washington imaged fluorescently-labeled aminoglycosides in the hair cells of live zebrafish and evaluated the transit of the antibiotic from the cytosol into lysosomes.
Published December 19, 2016
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Selective acetylcholine receptor modulation improves cognitive symptoms in mouse prion disease
Work led by Andrew Tobin at the University of Leicester tested two drugs that specifically target the M1 muscarinic acetylcholine receptor in a mouse model of prion disease and discovered that the treatments reversed cognitive decline.
Published December 19, 2016
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Golgi compaction supports metastasis initiated by epithelial-to-mesenchymal transition
Recent work by Jonathan Kurie’s lab at MD Anderson Cancer Center has shown that the epithelial-to-mesenchymal transition is accompanied a compaction of Golgi organelles that may enhance pro-metastatic vesicle trafficking...
Published November 21, 2016
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Adaptive vascularization in the heart after loss of hemoglobin S-nitrosylation
Work from Jonathan Stamler’s lab at Case Western Reserve University shows that S-nitrosylation plays a key role in protecting against ischemic cardiac injury and heart failure...
Published November 14, 2016
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