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Senescence and immunogenicity in medulloblastoma models are regulated by protein phosphatase 2A
In this episode, Rongze Olivia Lu, explains that the manuscript's findings identify PP2A as a regulator of immunogenic senescence in MB and support PP2Ac targeting as a therapeutic strategy...
Published July 1, 2026
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Poststroke outcomes and glymphatic function in mice are improved by chronotherapy
In this episode, Lauren Hablitz describes how the manuscript's findings suggest that reinforcing normal daily rhythmicity after stroke can markedly enhance neurological recovery, even when interventions are initiated several days after stroke onset...
Published June 15, 2026
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Crimean-Congo hemorrhagic fever virus glycoprotein 38 in mice is targeted with human antibodies
In this episode, James Crowe describes how these studies support the development of CCHFV countermeasures to induce protection against GP38 in vivo...
Published May 15, 2026
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Wolfram syndrome and a phase II trial of sodium phenylbutyrate and taurursodiol
In this episode, Fumihiko Urano describes how the manuscript reports 24- and 48-week results from the ongoing HELIOS trial (ClinicalTrials.gov NCT05676034), a single-center, single-arm, open-label, phase II trial of PB&TURSO...
Published May 15, 2026
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Distal wound healing is regulated by peritoneal macrophages via endocrine release
In this episode, Guido Beldi and Lilian Salm explain how their findings suggest that large peritoneal macrophages (LPMs), strategically positioned in the peritoneal cavity, serve as a source of circulating fibronectin...
Published May 1, 2026
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Depletion of hepatic glutathione and selective protein oxidation and inhibition of lipogenesis
In this episode, Xiang-Yu Liu explains that the manuscript's findings revise the conventional view of GSH in protein redox and demonstrate that targeted redox manipulation through GSH depletion protects against MASLD...
Published April 15, 2026
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CD8+ T cell neuroimmune surveillance following SIV infection is impaired by α4 integrin
In this episode Smita Iyer describe how the manuscript's findings establish that α4 integrin governs CD8-mediated neuroimmune surveillance through coordinated cellular positioning...
Published April 15, 2026
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A tuberculosis cure is accelerated by immunotherapy targeting
In this episode, Styliani Karanika describes how their findings underscore the potential of a strategy to advance therapeutic TB vaccine development targeting M. tuberculosis persisters...
Published April 10, 2026
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Genome/exome sequencing underestimates CHIP–disease associations
In this episode, Dr. Alexander G. Bick discusses how epidemiology studies underestimate how strongly clonal hematopoiesis is linked to disease because shallow whole-genome sequencing produces more false negatives compared with deep targeted sequencing...
Published April 8, 2026
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Predicting chronic graft-versus-host disease and mortality risk with BIOPREVENT
In this episode, Sophie Paczesny explains that BIOPREVENT accurately predicts individual risk of future cGVHD and NRM using biomarkers at 3 months post-HCT...
Published February 26, 2026
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