Video Abstracts

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Chronic lymphocytic leukemia and the inducement of a nongenetic adaptation to ibrutinib
In this episode, Laura Ondrisova describes how this manuscript examines a non-genetic adaptation to BTK inhibitor therapy in chronic lymphocytic leukemia that involves Akt activation via FoxO1/Rictor axis...
Published December 2, 2024
Video Abstracts
Macrophage subtypes mediate the development of the ordered architecture of regenerative tissues
In this episode, Andreas Patsalos and Laszlo Nagy explain that their findings suggest that macrophage subtypes mediated the development of the highly ordered architecture of regenerative tissues...
Published November 22, 2024
Video Abstracts
A dynamic multilayered tissue architecture is revealed in skeletal muscle
In this episode, Laszlo Nagy and colleagues, explain that macrophages coordinate tissue repair by promoting regenerative inflammation...
Published October 15, 2024
Video Abstracts
ADAMTS12 promotes fibrosis and enables activation of injury-responsive fibroblasts
In this episode, Rafael Kramann, Konrad Hoeft, and Lars Koch explain that catalytically active ADAMTS12 controls fibrosis by restructuring ECM to enable activation and migration of a distinct injury-responsive fibroblast subset after injury...
Published September 17, 2024
Video Abstracts
Sex- and age-specific differences revealed by mouse sarcopenia models
In this episode, Jose Garcia and Haiming Kerr describe how their study characterizes sarcopenia in aged mice using a clinically relevant definition, elucidating age-related changes in muscle mass and function...
Published August 15, 2024
Video Abstracts
Tet2 function and innate immune resistance to bacterial pneumonia
In this episode, Candice Quin explains how individuals with TET2-mutant CHIP are at increased risk of bacterial pneumonia due to innate immune impairments...
Published July 17, 2024
Video Abstracts
Prolonged transplant survival in preclinical models
In this episode, Leonardo Riella presents his manuscript detailing how a humanized mutein IL-2 selectively expands and boosts the function of mouse, non-human primate and human regulatory T cells, prolonging allograft survival...
Published April 24, 2024
Video Abstracts
A glycolysis/HIF1a axis in promoting G-MDSC activity and biofilm persistence during PJI is important
In this episode, Tammy Kielian, Kevin Garvin, Christopher Horn, and Prabhakar Arumugam describe how their study demonstrates the importance of a glycolysis/HIF1a axis in promoting G-MDSC anti-inflammatory activity and biofilm persistence during PJI...
Published April 23, 2024
Video Abstracts
Thrombotic microangiopathy is prevented in a case series of pig-to-human kidney xenotransplantation
In this episode, Jayme Locke and Maggie Jones-Carr explain the histologic outcomes of a series of brain-dead human recipients of a porcine kidney xenotransplant using exclusively FDA-approved medications, with and without anti-C5 monoclonal antibody...
Published March 1, 2024
Video Abstracts
Immune inhibitor receptor LAIR1 in gliomas and fibroblast–secreted collagen
In this episode, Shashwat Tripathi and Hinda Najem discuss how, using scRNA-seq, their analysis shows that CAFs, specifically the immune modulatory subtype, are increased in frequency as a function of glioma grade. Notably, collagen is a key ligand...
Published February 15, 2024
Video Abstracts
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