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STING-mediated antitumor immunity and CDK12/13 inactivation triggers
In this episode, Yi Bao explains the that the manuscript's findings establish STING activation as the key driver of T cell infiltration and the immune-hot tumor microenvironment in CDK12 mutant cancers...
Published September 16, 2025
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Spesolimab targets IL-36R to alleviate inflammation and reduce generalized pustular psoriasis flares
In this episode, James G. Kreuger explains that people with generalized pustular psoriasis experience underlying skin inflammation, even in the absence of flares. Spesolimab treatment helps control the inflammation and prevent future flares...
Published September 5, 2025
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Cyclin D1 overexpression causes replication stress and repair pathway dependence
In this episode, Dr. Jithma Prasad Abeykoon, explains how Cyclin D1 overexpression causes DNA damage and forces cancer cells to depend on targetable repair pathways...
Published September 2, 2025
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Baricitinib rapidly treats lichen planus by suppressing cytotoxic CXCL13+CD8+ T cells.
In this episode, Aaron R. Mangold explains how lichen planus is treated by suppressing cytotoxic CXCL13+CD8+ T-cells using baricitinib...
Published March 31, 2025
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Electronic health record data and the estimation of autoimmune disease prevalence in the USA
In this video, DeLisa Fairweather, Aaron H. Abend, and Ingrid He explain that their paper estimates the prevalence of all autoimmune disease in the US...
Published February 17, 2025
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Chronic lymphocytic leukemia and the inducement of a nongenetic adaptation to ibrutinib
In this episode, Laura Ondrisova describes how this manuscript examines a non-genetic adaptation to BTK inhibitor therapy in chronic lymphocytic leukemia that involves Akt activation via FoxO1/Rictor axis...
Published December 2, 2024
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Macrophage subtypes mediate the development of the ordered architecture of regenerative tissues
In this episode, Andreas Patsalos and Laszlo Nagy explain that their findings suggest that macrophage subtypes mediated the development of the highly ordered architecture of regenerative tissues...
Published November 22, 2024
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A dynamic multilayered tissue architecture is revealed in skeletal muscle
In this episode, Laszlo Nagy and colleagues, explain that macrophages coordinate tissue repair by promoting regenerative inflammation...
Published October 15, 2024
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ADAMTS12 promotes fibrosis and enables activation of injury-responsive fibroblasts
In this episode, Rafael Kramann, Konrad Hoeft, and Lars Koch explain that catalytically active ADAMTS12 controls fibrosis by restructuring ECM to enable activation and migration of a distinct injury-responsive fibroblast subset after injury...
Published September 17, 2024
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Sex- and age-specific differences revealed by mouse sarcopenia models
In this episode, Jose Garcia and Haiming Kerr describe how their study characterizes sarcopenia in aged mice using a clinically relevant definition, elucidating age-related changes in muscle mass and function...
Published August 15, 2024
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