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CaMK4 drives podocyte injury
In this episode, George Tsokos and colleagues reveal that CaMK4-mediated signaling directly promotes podocyte dysfunction…
Published July 9, 2018
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Altered abiraterone metabolism in individuals with HSD3B1 variant
Nima Sharifi and colleagues demonstrate altered abiraterone metabolism in individuals with the HSD3B1(1245C) variant that may influence clinical response…
Published June 25, 2018
Author's Take
JAK inhibitor treatment shows benefit for patients with interferonopathies
In this episode, Gina A. Montealegre Sanchez, Raphaela Goldbach-Mansky, and colleagues demonstrate that JAK1/2 inhibitor baricitinib improves clinical manifestations in a small cohort of patients with interferonopathies…
Published June 11, 2018
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REV-ERBα controls the clock in the lung
In this episode, David Ray, Marie Pariollaud and colleagues identify REV-ERBα as a critical regulator of rhythmic inflammatory responses in the lung…
Published April 30, 2018
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Immune tolerance-like pathway inhibits repair following white matter injury
Stephen Back and colleagues identify an immune tolerance-like pathway that prevents repair after white matter injury…
Published April 16, 2018
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Vaginal epithelial shedding mediates ascending group B streptococcus infection
In this episode, Lakshmi Rajagopal provide evidence that group B streptococcus-induced exfoliation of the vaginal epithelium promotes ascending infection…
Published April 9, 2018
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A role for plasminogen activator inhibitor type 1 in skin fibrosis
In this episode, Colin Jamora, Neha Pincha, and colleagues demonstrate a role for plasminogen activator inhibitor type 1 in driving fibrogenesis in a murine model of skin fibrosis…
Published March 26, 2018
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CD163+ macrophages serve pathogenic role in atherosclerosis
In this episode Aloke Finn, Liang Guo and colleagues reveal that a population of alternatively activated CD163+ macrophages, previously thought to be atheroprotective, are instead pathogenic….
Published February 19, 2018
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Tie1 deficiency limits cancer progression and metastasis
In this episode, Hellmut Augustin, Silvia La Porta, and colleagues link the orphan receptor Tie1 within intratumoral vasculature to cancer progression and metastasis…
Published January 22, 2018
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Identification and characterization of GDF6 as a driver of melanoma
In this episode, Craig Ceol, Arvind Venkatesan, and colleagues identify GDF6-mediated BMP signaling as a driver of melanoma and potential therapeutic target...
Published December 4, 2017
Author's Take
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