Author's Take

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Angiopoietin/Tie2 maintain the flow of Schlemm’s canal
Gou Young Koh, Jaeryung Kim, and Dae-Young Park discuss their work, which identifies angiopoietin/Tie2 as a critical pathway in maintaining the integrity and function of Schlemm’s canal…
Published September 18, 2017
Author's Take
Gene expression profile predicts response to pembrolizumab
In this episode, Terri McClanahan and Jared Lunceford identify a gene expression profile that correlates with a beneficial response to anti-PD-1 therapy
Published June 26, 2017
Author's Take
Neuropeptide FF acts on adipose tissue macrophages
Tamás Röszer and colleagues identify neuropeptide FF as an important player in the maintenance of healthy adipose tissue…
Published June 5, 2017
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Characterizing the cells that underlie breast cancer recurrence
In this episode, Martin Jechlinger and colleagues show altered lipid metabolism and increased ROS production in residual breast cancer cells…
Published May 15, 2017
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OX40 signals death for liver-resident immune cells
In this episode, Xian Li and colleagues demonstrate that stimulation of cell surface receptor OX40 induces pyroptosis in a liver-resident immune cell population.....
Published April 24, 2017
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Unravelling differences in arthritis manifestation in mast cell-deficient mice
Peter Nigrovic and colleagues reveal that marrow and stromal context determine the role of mast cells in inflammation and that megakaryocytes can directly mediate inflammation...
Published April 4, 2017
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Insight into lupus-associated CD11b mutations
In this episode, Marian Kaplan and Vineet Gupta reveal that lupus-associated mutations in the CD11b-encoding gene reduce CD11b function and that small molecule activation of CD11b ameliorates disease in mouse models of lupus...
Published April 3, 2017
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Using proteomics to predict heart disease
In this episode, Manuel Mayr and colleagues use a proteomic approach to identify biomarkers of cardiovascular disease progression...
Published March 20, 2017
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Donor tissue-derived exosomes may predict transplant rejection
In this episode, Prashanth Vallabhajosyula and colleagues present evidence that donor-derived exosomes can be used to noninvasively monitor immune-meditated transplant rejection...
Published March 20, 2017
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Epigenetic targeting improves metabolic defects in obesity-prone mice
In this episode, Mitchell Lazar and Raymond Soccio discuss their work, which shows that epigenetic modification can rescue genetic metabolic defects...
Published February 27, 2017
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