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Citations to this article

Maturing of the nuclear receptor family
Mitchell A. Lazar
Mitchell A. Lazar
Published April 3, 2017
Citation Information: J Clin Invest. 2017;127(4):1123-1125. https://doi.org/10.1172/JCI92949.
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Review Series Article has an altmetric score of 4

Maturing of the nuclear receptor family

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Abstract

Members of the nuclear receptor (NR) superfamily of ligand-regulated transcription factors play important roles in reproduction, development, and physiology. In humans, genetic mutations in NRs are causes of rare diseases, while hormones and drugs that target NRs are in widespread therapeutic use. The present issue of the JCI includes a series of Review articles focused on specific NRs and their wide range of biological functions. Here I reflect on the past, present, and potential future highlights of research on the NR superfamily.

Authors

Mitchell A. Lazar

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 Total
Citations: 2 5 7 7 8 4 4 4 41
Citation information
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Citations to this article in year 2023 (7)

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An IL-6/STAT3/MR/FGF21 axis mediates heart-liver cross-talk after myocardial infarction.
Sun JY, Du LJ, Shi XR, Zhang YY, Liu Y, Wang YL, Chen BY, Liu T, Zhu H, Liu Y, Ruan CC, Gan Z, Ying H, Yin Z, Gao PJ, Yan X, Li RG, Duan SZ
Science Advances 2023
Nuclear Receptors in Health and Diseases
Xu P
International journal of molecular sciences 2023
Hidden modes of DNA binding by human nuclear receptors.
Bhimsaria D, Rodríguez-Martínez JA, Mendez-Johnson JL, Ghoshdastidar D, Varadarajan A, Bansal M, Daniels DL, Ramanathan P, Ansari AZ
Nature Communications 2023
ESS2 controls prostate cancer progression through recruitment of chromodomain helicase DNA binding protein 1.
Takahashi S, Takada I, Hashimoto K, Yokoyama A, Nakagawa T, Makishima M, Kume H
Scientific Reports 2023
Asymmetric dimerization in a transcription factor superfamily is promoted by allosteric interactions with DNA
Patel AK, Vilela P, Shaik TB, McEwen AG, Hazemann I, Brillet K, Ennifar E, Hamiche A, Markov GV, Laudet V, Moras D, Klaholz BP, Billas IM
Nucleic Acids Research 2023
PAXIP1 and STAG2 converge to maintain 3D genome architecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription
Mayayo-Peralta I, Gregoricchio S, Schuurman K, Yavuz S, Zaalberg A, Kojic A, Abbott N, Geverts B, Beerthuijzen S, Siefert J, Severson TM, van Baalen M, Hoekman L, Lieftink C, Altelaar M, Beijersbergen RL, Houtsmuller AB, Prekovic S, Zwart W
Nucleic Acids Research 2023
Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by derivatives of a promiscuous nuclear receptor ligand
Huber AD, Poudel S, Li Y, Lin W, Wu J, Miller DJ, Chen T
Structure (London, England : 1993) 2023

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