Members of the nuclear receptor (NR) superfamily of ligand-regulated transcription factors play important roles in reproduction, development, and physiology. In humans, genetic mutations in NRs are causes of rare diseases, while hormones and drugs that target NRs are in widespread therapeutic use. The present issue of the
Mitchell A. Lazar
Title and authors | Publication | Year |
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An IL-6/STAT3/MR/FGF21 axis mediates heart-liver cross-talk after myocardial infarction.
Sun JY, Du LJ, Shi XR, Zhang YY, Liu Y, Wang YL, Chen BY, Liu T, Zhu H, Liu Y, Ruan CC, Gan Z, Ying H, Yin Z, Gao PJ, Yan X, Li RG, Duan SZ |
Science Advances | 2023 |
Nuclear Receptors in Health and Diseases
Xu P |
International journal of molecular sciences | 2023 |
Hidden modes of DNA binding by human nuclear receptors.
Bhimsaria D, Rodríguez-Martínez JA, Mendez-Johnson JL, Ghoshdastidar D, Varadarajan A, Bansal M, Daniels DL, Ramanathan P, Ansari AZ |
Nature Communications | 2023 |
ESS2 controls prostate cancer progression through recruitment of chromodomain helicase DNA binding protein 1.
Takahashi S, Takada I, Hashimoto K, Yokoyama A, Nakagawa T, Makishima M, Kume H |
Scientific Reports | 2023 |
Asymmetric dimerization in a transcription factor superfamily is promoted by allosteric interactions with DNA
Patel AK, Vilela P, Shaik TB, McEwen AG, Hazemann I, Brillet K, Ennifar E, Hamiche A, Markov GV, Laudet V, Moras D, Klaholz BP, Billas IM |
Nucleic Acids Research | 2023 |
PAXIP1 and STAG2 converge to maintain 3D genome architecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription
Mayayo-Peralta I, Gregoricchio S, Schuurman K, Yavuz S, Zaalberg A, Kojic A, Abbott N, Geverts B, Beerthuijzen S, Siefert J, Severson TM, van Baalen M, Hoekman L, Lieftink C, Altelaar M, Beijersbergen RL, Houtsmuller AB, Prekovic S, Zwart W |
Nucleic Acids Research | 2023 |
Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by derivatives of a promiscuous nuclear receptor ligand
Huber AD, Poudel S, Li Y, Lin W, Wu J, Miller DJ, Chen T |
Structure (London, England : 1993) | 2023 |