Members of the nuclear receptor (NR) superfamily of ligand-regulated transcription factors play important roles in reproduction, development, and physiology. In humans, genetic mutations in NRs are causes of rare diseases, while hormones and drugs that target NRs are in widespread therapeutic use. The present issue of the
Mitchell A. Lazar
Title and authors | Publication | Year |
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PbsNRs: predict the potential binders and scaffolds for nuclear receptors
Zheng G, Wu D, Wei X, Xu D, Mao T, Yan D, Han W, Shang X, Chen Z, Qiu J, Tang K, Cao Z, Qiu T |
Briefings in Bioinformatics | 2025 |
Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR
Garcia-Maldonado E, Huber AD, Chai SC, Nithianantham S, Li Y, Wu J, Poudel S, Miller DJ, Seetharaman J, Chen T |
Nature Communications | 2024 |
Targeting Androgen, Thyroid Hormone, and Vitamin A and D Receptors to Treat Prostate Cancer
Hantusch B, Kenner L, Stanulović VS, Hoogenkamp M, Brown G |
International Journal of Molecular Sciences | 2024 |
Regulatory mechanisms of steroid hormone receptors on gene transcription through chromatin interaction and enhancer reprogramming.
Sun G, Zhao C, Han J, Wu S, Chen Y, Yao J, Li L |
Cellular oncology (Dordrecht, Netherlands) | 2024 |
A pan-family screen of Nuclear Receptors in immunocytes reveals ligand-dependent inflammasome control
Wang Y, Zhang Y, Kim K, Han J, Okin D, Jiang Z, Yang L, Subramaniam A, Means TK, Nestlé FO, Fitzgerald KA, Randolph GJ, Lesser CF, Kagan JC, Mathis D, Benoist C |
Immunity | 2024 |
An IL-6/STAT3/MR/FGF21 axis mediates heart-liver cross-talk after myocardial infarction.
Sun JY, Du LJ, Shi XR, Zhang YY, Liu Y, Wang YL, Chen BY, Liu T, Zhu H, Liu Y, Ruan CC, Gan Z, Ying H, Yin Z, Gao PJ, Yan X, Li RG, Duan SZ |
Science Advances | 2023 |
Nuclear Receptors in Health and Diseases
Xu P |
International journal of molecular sciences | 2023 |
Hidden modes of DNA binding by human nuclear receptors.
Bhimsaria D, Rodríguez-Martínez JA, Mendez-Johnson JL, Ghoshdastidar D, Varadarajan A, Bansal M, Daniels DL, Ramanathan P, Ansari AZ |
Nature Communications | 2023 |
ESS2 controls prostate cancer progression through recruitment of chromodomain helicase DNA binding protein 1.
Takahashi S, Takada I, Hashimoto K, Yokoyama A, Nakagawa T, Makishima M, Kume H |
Scientific Reports | 2023 |
Asymmetric dimerization in a transcription factor superfamily is promoted by allosteric interactions with DNA
Patel AK, Vilela P, Shaik TB, McEwen AG, Hazemann I, Brillet K, Ennifar E, Hamiche A, Markov GV, Laudet V, Moras D, Klaholz BP, Billas IM |
Nucleic Acids Research | 2023 |
PAXIP1 and STAG2 converge to maintain 3D genome architecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription
Mayayo-Peralta I, Gregoricchio S, Schuurman K, Yavuz S, Zaalberg A, Kojic A, Abbott N, Geverts B, Beerthuijzen S, Siefert J, Severson TM, van Baalen M, Hoekman L, Lieftink C, Altelaar M, Beijersbergen RL, Houtsmuller AB, Prekovic S, Zwart W |
Nucleic Acids Research | 2023 |
Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by derivatives of a promiscuous nuclear receptor ligand
Huber AD, Poudel S, Li Y, Lin W, Wu J, Miller DJ, Chen T |
Structure (London, England : 1993) | 2023 |
PPARγ2 functions as a tumor suppressor in a translational mouse model of human prostate cancer
F Dong, D Liu, T Lu, F Li, C Zhang, Q E, Y Zhang |
Asian Journal of Andrology | 2022 |
Full Functional Sex Reversal Achieved Through Silencing of MroDmrt11E Gene in Macrobrachium rosenbergii: Production of All-Male Monosex Freshwater Prawn
H Xu, Y Chen, Y Wang, J Luo, J Li, S Shen, J Yang, W Ma |
Frontiers in Endocrinology | 2022 |
Obesity alters pathology and treatment response in inflammatory disease
S Bapat, C Whitty, C Mowery, Y Liang, A Yoo, Z Jiang, M Peters, L Zhang, I Vogel, C Zhou, V Nguyen, Z Li, C Chang, W Zhu, A Hastie, H He, X Ren, W Qiu, S Gayer, C Liu, E Choi, M Fassett, J Cohen, J Sturgill, L Alexander, J Suh, C Liddle, A Atkins, R Yu, M Downes, S Liu, B Nikolajczyk, I Lee, E Guttman-Yassky, K Ansel, P Woodruff, J Fahy, D Sheppard, R Gallo, C Ye, R Evans, Y Zheng, A Marson |
Nature | 2022 |
Role of Bile Acids and Nuclear Receptors in Acupuncture in Improving Crohn’s Disease
J Shen, Q Qi, D Han, S Liu, R Huang, Y Zhu, H Zheng, K Gu, H Wu, H Liu, A Haque |
Evidence-Based Complementary and Alternative Medicine | 2022 |
Protein phosphatase 2A regulates cytotoxicity and drug resistance by dephosphorylating AHR and MDR1
L Chen, P Guo, W Li, X Jiang, Q Zhao, D Li, Q Wang, Y Xiao, X Xing, Y Pang, M Aschner, L Zhang, W Chen |
The Journal of biological chemistry | 2022 |
Nuclear Receptor Coregulators in Hormone-Dependent Cancers
Jafari H, Hussain S, Campbell MJ |
Cancers | 2022 |
Crosstalk between Thyroid Hormone and Corticosteroid Signaling Targets Cell Proliferation in Xenopus tropicalis Tadpole Liver
Rigolet M, Buisine N, Scharwatt M, Duvernois-Berthet E, Buchholz DR, Sachs LM |
International journal of molecular sciences | 2022 |
Nuclear receptors: a bridge linking the gut microbiome and the host
Z Wang, WD Chen, YD Wang |
Molecular Medicine | 2021 |
Genome-wide crosstalk between steroid receptors in breast and prostate cancers
V Paakinaho, JJ Palvimo |
Endocrine Related Cancer | 2021 |
CAR directs T cell adaptation to bile acids in the small intestine
ML Chen, X Huang, H Wang, C Hegner, Y Liu, J Shang, A Eliason, H Diao, HJ Park, B Frey, G Wang, SA Mosure, LA Solt, DJ Kojetin, A Rodriguez-Palacios, DA Schady, CT Weaver, ME Pipkin, DD Moore, MS Sundrud |
Nature | 2021 |
A structural signature motif enlightens the origin and diversification of nuclear receptors
B Beinsteiner, GV Markov, S Erb, Y Chebaro, AG McEwen, S Cianférani, V Laudet, D Moras, IM Billas, A Kopp |
PLoS genetics | 2021 |
Transcriptome and Methylome Analysis Reveal Complex Cross-Talks between Thyroid Hormone and Glucocorticoid Signaling at Xenopus Metamorphosis
N Buisine, A Grimaldi, V Jonchere, M Rigolet, C Blugeon, J Hamroune, LM Sachs |
Cells | 2021 |
Inhibition of nuclear receptor RORα attenuates cartilage damage in osteoarthritis by modulating IL-6/STAT3 pathway
T Liang, T Chen, J Qiu, W Gao, X Qiu, Y Zhu, X Wang, Y Chen, H Zhou, Z Deng, P Li, C Xu, Y Peng, A Liang, P Su, B Gao, D Huang |
Cell Death and Disease | 2021 |
Acetylenic Synthetic Betulin Derivatives Inhibit Akt and Erk Kinases Activity, Trigger Apoptosis and Suppress Proliferation of Neuroblastoma and Rhabdomyosarcoma Cell Lines
SK Król, E Bębenek, M Dmoszyńska-Graniczka, A Sławińska-Brych, S Boryczka, A Stepulak |
International journal of molecular sciences | 2021 |
An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors
Garcia DA, Johnson TA, Presman DM, Fettweis G, Wagh K, Rinaldi L, Stavreva DA, Paakinaho V, Jensen RA, Mandrup S, Upadhyaya A, Hager GL |
Molecular Cell | 2021 |
Nuclear Receptor Coactivators (NCOAs) and Corepressors (NCORs) in the Brain
Z Sun, Y Xu |
Endocrinology | 2020 |
The Nuclear Orphan Receptor NR2F6 Promotes Hepatic Steatosis through Upregulation of Fatty Acid Transporter CD36
B Zhou, L Jia, Z Zhang, L Xiang, Y Yuan, P Zheng, B Liu, X Ren, H Bian, L Xie, Y Li, J Lu, H Zhang, Y Lu |
Advanced Science | 2020 |
Application of In Vitro Metabolism Activation in High-Throughput Screening
M Ooka, C Lynch, M Xia |
International journal of molecular sciences | 2020 |
Thyroid Hormone Signaling in Embryonic Stem Cells: Crosstalk with the Retinoic Acid Pathway
M Fernández, M Pannella, VA Baldassarro, A Flagelli, G Alastra, L Giardino, L Calzà |
International journal of molecular sciences | 2020 |
TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile
K Dendoncker, S Timmermans, J Vandewalle, M Eggermont, J Lempiäinen, V Paakinaho, EV Hamme, S Dewaele, S Vandevyver, M Ballegeer, J Souffriau, LV Wyngene, KV Looveren, T Vanderhaeghen, R Beyaert, KD Bosscher, JJ Palvimo, MV Montagu, C Libert |
Proceedings of the National Academy of Sciences | 2019 |
Genomic insights into MeCP2 function: A role for the maintenance of chromatin architecture
DR Connolly, Z Zhou |
Current Opinion in Neurobiology | 2019 |
Transcriptional profiling of spiny lobster metamorphosis reveals three new additions to the nuclear receptor superfamily
CJ Hyde, QP Fitzgibbon, A Elizur, GG Smith, T Ventura |
BMC Genomics | 2019 |
Regulation of calcific vascular and valvular disease by nuclear receptors:
T Sallam, Y Tintut, LL Demer |
Current Opinion in Lipidology | 2019 |
Reversing the Curse on PPAR (gamma not showing up)
Mitchell A. Lazar |
Journal of Clinical Investigation | 2018 |
The nuclear receptor RORα protects against angiotensin II-induced cardiac hypertrophy and heart failure
JY Beak, HS Kang, W Huang, PH Myers, DE Bowles, AM Jetten, B Jensen |
American journal of physiology. Heart and circulatory physiology | 2018 |
Chromatin reprogramming in breast cancer
EE Swinstead, V Paakinaho, GL Hager |
Endocrine Related Cancer | 2018 |
Deciphering Steroid Receptor Crosstalk in Hormone-Driven Cancers
TH Truong, CA Lange |
Endocrinology | 2018 |