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Citations to this article

Maturing of the nuclear receptor family
Mitchell A. Lazar
Mitchell A. Lazar
Published April 3, 2017
Citation Information: J Clin Invest. 2017;127(4):1123-1125. https://doi.org/10.1172/JCI92949.
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Review Series Article has an altmetric score of 4

Maturing of the nuclear receptor family

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Abstract

Members of the nuclear receptor (NR) superfamily of ligand-regulated transcription factors play important roles in reproduction, development, and physiology. In humans, genetic mutations in NRs are causes of rare diseases, while hormones and drugs that target NRs are in widespread therapeutic use. The present issue of the JCI includes a series of Review articles focused on specific NRs and their wide range of biological functions. Here I reflect on the past, present, and potential future highlights of research on the NR superfamily.

Authors

Mitchell A. Lazar

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 Total
Citations: 1 5 7 7 8 4 4 4 40
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Citations to this article (40)

Title and authors Publication Year
PbsNRs: predict the potential binders and scaffolds for nuclear receptors
Zheng G, Wu D, Wei X, Xu D, Mao T, Yan D, Han W, Shang X, Chen Z, Qiu J, Tang K, Cao Z, Qiu T
Briefings in Bioinformatics 2025
Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR
Garcia-Maldonado E, Huber AD, Chai SC, Nithianantham S, Li Y, Wu J, Poudel S, Miller DJ, Seetharaman J, Chen T
Nature Communications 2024
Targeting Androgen, Thyroid Hormone, and Vitamin A and D Receptors to Treat Prostate Cancer
Hantusch B, Kenner L, Stanulović VS, Hoogenkamp M, Brown G
International Journal of Molecular Sciences 2024
Regulatory mechanisms of steroid hormone receptors on gene transcription through chromatin interaction and enhancer reprogramming.
Sun G, Zhao C, Han J, Wu S, Chen Y, Yao J, Li L
Cellular oncology (Dordrecht, Netherlands) 2024
A pan-family screen of Nuclear Receptors in immunocytes reveals ligand-dependent inflammasome control
Wang Y, Zhang Y, Kim K, Han J, Okin D, Jiang Z, Yang L, Subramaniam A, Means TK, Nestlé FO, Fitzgerald KA, Randolph GJ, Lesser CF, Kagan JC, Mathis D, Benoist C
Immunity 2024
SLC7A11 as a therapeutic target to attenuate phthalates-driven testosterone level decline in mice
Zhao Y, Wang XQ, Liu RQ, Jiang FW, Wang JX, Chen MS, Zhang H, Cui JG, Chang YH, Li JL
Journal of Advanced Research 2024
An IL-6/STAT3/MR/FGF21 axis mediates heart-liver cross-talk after myocardial infarction.
Sun JY, Du LJ, Shi XR, Zhang YY, Liu Y, Wang YL, Chen BY, Liu T, Zhu H, Liu Y, Ruan CC, Gan Z, Ying H, Yin Z, Gao PJ, Yan X, Li RG, Duan SZ
Science Advances 2023
Nuclear Receptors in Health and Diseases
Xu P
International journal of molecular sciences 2023
Hidden modes of DNA binding by human nuclear receptors.
Bhimsaria D, Rodríguez-Martínez JA, Mendez-Johnson JL, Ghoshdastidar D, Varadarajan A, Bansal M, Daniels DL, Ramanathan P, Ansari AZ
Nature Communications 2023
ESS2 controls prostate cancer progression through recruitment of chromodomain helicase DNA binding protein 1.
Takahashi S, Takada I, Hashimoto K, Yokoyama A, Nakagawa T, Makishima M, Kume H
Scientific Reports 2023
Asymmetric dimerization in a transcription factor superfamily is promoted by allosteric interactions with DNA
Patel AK, Vilela P, Shaik TB, McEwen AG, Hazemann I, Brillet K, Ennifar E, Hamiche A, Markov GV, Laudet V, Moras D, Klaholz BP, Billas IM
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PAXIP1 and STAG2 converge to maintain 3D genome architecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription
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Nucleic Acids Research 2023
Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by derivatives of a promiscuous nuclear receptor ligand
Huber AD, Poudel S, Li Y, Lin W, Wu J, Miller DJ, Chen T
Structure (London, England : 1993) 2023
PPARγ2 functions as a tumor suppressor in a translational mouse model of human prostate cancer
F Dong, D Liu, T Lu, F Li, C Zhang, Q E, Y Zhang
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H Xu, Y Chen, Y Wang, J Luo, J Li, S Shen, J Yang, W Ma
Frontiers in Endocrinology 2022
Obesity alters pathology and treatment response in inflammatory disease
S Bapat, C Whitty, C Mowery, Y Liang, A Yoo, Z Jiang, M Peters, L Zhang, I Vogel, C Zhou, V Nguyen, Z Li, C Chang, W Zhu, A Hastie, H He, X Ren, W Qiu, S Gayer, C Liu, E Choi, M Fassett, J Cohen, J Sturgill, L Alexander, J Suh, C Liddle, A Atkins, R Yu, M Downes, S Liu, B Nikolajczyk, I Lee, E Guttman-Yassky, K Ansel, P Woodruff, J Fahy, D Sheppard, R Gallo, C Ye, R Evans, Y Zheng, A Marson
Nature 2022
Role of Bile Acids and Nuclear Receptors in Acupuncture in Improving Crohn’s Disease
J Shen, Q Qi, D Han, S Liu, R Huang, Y Zhu, H Zheng, K Gu, H Wu, H Liu, A Haque
Evidence-Based Complementary and Alternative Medicine 2022
Protein phosphatase 2A regulates cytotoxicity and drug resistance by dephosphorylating AHR and MDR1
L Chen, P Guo, W Li, X Jiang, Q Zhao, D Li, Q Wang, Y Xiao, X Xing, Y Pang, M Aschner, L Zhang, W Chen
The Journal of biological chemistry 2022
Nuclear Receptor Coregulators in Hormone-Dependent Cancers
Jafari H, Hussain S, Campbell MJ
Cancers 2022
Crosstalk between Thyroid Hormone and Corticosteroid Signaling Targets Cell Proliferation in Xenopus tropicalis Tadpole Liver
Rigolet M, Buisine N, Scharwatt M, Duvernois-Berthet E, Buchholz DR, Sachs LM
International journal of molecular sciences 2022
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Z Wang, WD Chen, YD Wang
Molecular Medicine 2021
Genome-wide crosstalk between steroid receptors in breast and prostate cancers
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Endocrine Related Cancer 2021
CAR directs T cell adaptation to bile acids in the small intestine
ML Chen, X Huang, H Wang, C Hegner, Y Liu, J Shang, A Eliason, H Diao, HJ Park, B Frey, G Wang, SA Mosure, LA Solt, DJ Kojetin, A Rodriguez-Palacios, DA Schady, CT Weaver, ME Pipkin, DD Moore, MS Sundrud
Nature 2021
A structural signature motif enlightens the origin and diversification of nuclear receptors
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