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Citations to this article

A leptin-regulated circuit controls glucose mobilization during noxious stimuli
Jonathan N. Flak, … , Kamal Rahmouni, Martin G. Myers Jr.
Jonathan N. Flak, … , Kamal Rahmouni, Martin G. Myers Jr.
Published July 17, 2017
Citation Information: J Clin Invest. 2017;127(8):3103-3113. https://doi.org/10.1172/JCI90147.
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Research Article Endocrinology Neuroscience Article has an altmetric score of 6

A leptin-regulated circuit controls glucose mobilization during noxious stimuli

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Abstract

Adipocytes secrete the hormone leptin to signal the sufficiency of energy stores. Reductions in circulating leptin concentrations reflect a negative energy balance, which augments sympathetic nervous system (SNS) activation in response to metabolically demanding emergencies. This process ensures adequate glucose mobilization despite low energy stores. We report that leptin receptor–expressing neurons (LepRb neurons) in the periaqueductal gray (PAG), the largest population of LepRb neurons in the brain stem, mediate this process. Application of noxious stimuli, which often signal the need to mobilize glucose to support an appropriate response, activated PAG LepRb neurons, which project to and activate parabrachial nucleus (PBN) neurons that control SNS activation and glucose mobilization. Furthermore, activating PAG LepRb neurons increased SNS activity and blood glucose concentrations, while ablating LepRb in PAG neurons augmented glucose mobilization in response to noxious stimuli. Thus, decreased leptin action on PAG LepRb neurons augments the autonomic response to noxious stimuli, ensuring sufficient glucose mobilization during periods of acute demand in the face of diminished energy stores.

Authors

Jonathan N. Flak, Deanna Arble, Warren Pan, Christa Patterson, Thomas Lanigan, Paulette B. Goforth, Jamie Sacksner, Maja Joosten, Donald A. Morgan, Margaret B. Allison, John Hayes, Eva Feldman, Randy J. Seeley, David P. Olson, Kamal Rahmouni, Martin G. Myers Jr.

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 Total
Citations: 1 4 1 1 2 4 2 7 22
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2018 (7)

Title and authors Publication Year
Remote control of glucose-sensing neurons to analyze glucose metabolism
A Alvarsson, SA Stanley
American journal of physiology. Endocrinology and metabolism 2018
Leptin and the maintenance of elevated body weight
WW Pan, MG Myers
Nature Reviews Neuroscience 2018
The Parabrachial Nucleus: CGRP Neurons Function as a General Alarm
RD Palmiter
Trends in Neurosciences 2018
In Uncontrolled Diabetes, Hyperglucagonemia and Ketosis Result From Deficient Leptin Action in the Parabrachial Nucleus
TH Meek, ME Matsen, CL Faber, CL Samstag, V Damian, HT Nguyen, JM Scarlett, JN Flak, MG Myers, GJ Morton
Endocrinology 2018
The Bidirectional Relationship Between Obstructive Sleep Apnea and Metabolic Disease
SN Framnes, DM Arble
Frontiers in Endocrinology 2018
Differential contribution of POMC and AgRP neurons to the regulation of regional autonomic nerve activity by leptin
BB Bell, SM Harlan, DA Morgan, DF Guo, K Rahmouni
Molecular Metabolism 2018
Distinct Neuronal Projections From the Hypothalamic Ventromedial Nucleus Mediate Glycemic and Behavioral Effects
CL Faber, ME Matsen, KR Velasco, V Damian, BA Phan, D Adam, A Therattil, MW Schwartz, GJ Morton
Diabetes 2018

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