Nuclear receptors: emerging drug targets for parasitic diseases
Zhu Wang,1 Nathaniel E. Schaffer,1 Steven A. Kliewer,1,2 and David J. Mangelsdorf1,3
1Department of Pharmacology,
2Department of Molecular Biology, and
3Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Address correspondence to: Steven A. Kliewer or David J. Mangelsdorf, University of Texas Southwestern Medical Center, 6001 Forest Park Rd., Dallas, Texas 75390, USA. Phone: 214.645.6304; E-mail: steven.kliewer@utsouthwestern.edu (S.A. Kliewer). Phone: 214.645.5957; E-mail: davo.mango@utsouthwestern.edu (D.J. Mangelsdorf).
Authorship note: Z. Wang and N.E. Schaffer are co–first authors.
Find articles by Wang, Z. in: JCI | PubMed | Google Scholar
1Department of Pharmacology,
2Department of Molecular Biology, and
3Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Address correspondence to: Steven A. Kliewer or David J. Mangelsdorf, University of Texas Southwestern Medical Center, 6001 Forest Park Rd., Dallas, Texas 75390, USA. Phone: 214.645.6304; E-mail: steven.kliewer@utsouthwestern.edu (S.A. Kliewer). Phone: 214.645.5957; E-mail: davo.mango@utsouthwestern.edu (D.J. Mangelsdorf).
Authorship note: Z. Wang and N.E. Schaffer are co–first authors.
Find articles by Schaffer, N. in: JCI | PubMed | Google Scholar
1Department of Pharmacology,
2Department of Molecular Biology, and
3Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Address correspondence to: Steven A. Kliewer or David J. Mangelsdorf, University of Texas Southwestern Medical Center, 6001 Forest Park Rd., Dallas, Texas 75390, USA. Phone: 214.645.6304; E-mail: steven.kliewer@utsouthwestern.edu (S.A. Kliewer). Phone: 214.645.5957; E-mail: davo.mango@utsouthwestern.edu (D.J. Mangelsdorf).
Authorship note: Z. Wang and N.E. Schaffer are co–first authors.
Find articles by Kliewer, S. in: JCI | PubMed | Google Scholar
1Department of Pharmacology,
2Department of Molecular Biology, and
3Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Address correspondence to: Steven A. Kliewer or David J. Mangelsdorf, University of Texas Southwestern Medical Center, 6001 Forest Park Rd., Dallas, Texas 75390, USA. Phone: 214.645.6304; E-mail: steven.kliewer@utsouthwestern.edu (S.A. Kliewer). Phone: 214.645.5957; E-mail: davo.mango@utsouthwestern.edu (D.J. Mangelsdorf).
Authorship note: Z. Wang and N.E. Schaffer are co–first authors.
Find articles by Mangelsdorf, D. in: JCI | PubMed | Google Scholar
First published February 6, 2017 - More info
J Clin Invest. 2017;127(4):1165–1171. doi:10.1172/JCI88890.
Copyright © 2017, American Society for Clinical Investigation
Parasitic worms infect billions of people worldwide. Current treatments rely on a small group of drugs that have been used for decades. A shortcoming of these drugs is their inability to target the intractable infectious stage of the parasite. As well-known therapeutic targets in mammals, nuclear receptors have begun to be studied in parasitic worms, where they are widely distributed and play key roles in governing metabolic and developmental transcriptional networks. One such nuclear receptor is DAF-12, which is required for normal nematode development, including the all-important infectious stage. Here we review the emerging literature that implicates DAF-12 and potentially other nuclear receptors as novel anthelmintic targets.
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