Nuclear hormone receptors in parasitic helminths

W Wu, PT LoVerde - Molecular and cellular endocrinology, 2011 - Elsevier
W Wu, PT LoVerde
Molecular and cellular endocrinology, 2011Elsevier
Nuclear receptors (NRs) belong to a large protein superfamily that are important
transcriptional modulators in metazoans. Parasitic helminths include parasitic worms from
the Lophotrochozoa (Platyhelminths) and Ecdysozoa (Nematoda). NRs in parasitic
helminths diverged into two different evolutionary lineages. NRs in parasitic Platyhelminths
have orthologues in Deuterostomes, in arthropods or both with a feature of extensive gene
loss and gene duplication within different gene groups. NRs in parasitic Nematoda follow …
Nuclear receptors (NRs) belong to a large protein superfamily that are important transcriptional modulators in metazoans. Parasitic helminths include parasitic worms from the Lophotrochozoa (Platyhelminths) and Ecdysozoa (Nematoda). NRs in parasitic helminths diverged into two different evolutionary lineages. NRs in parasitic Platyhelminths have orthologues in Deuterostomes, in arthropods or both with a feature of extensive gene loss and gene duplication within different gene groups. NRs in parasitic Nematoda follow the nematode evolutionary lineage with a feature of multiple duplication of SupNRs and gene loss.
Elsevier