[HTML][HTML] Structural conservation of ligand binding reveals a bile acid-like signaling pathway in nematodes
Bile acid-like molecules named dafachronic acids (DAs) control the dauer formation
program in Caenorhabditis elegans through the nuclear receptor DAF-12. This mechanism
is conserved in parasitic nematodes to regulate their dauer-like infective larval stage, and as
such, the DAF-12 ligand binding domain has been identified as an important therapeutic
target in human parasitic hookworm species that infect more than 600 million people
worldwide. Here, we report two x-ray crystal structures of the hookworm Ancylostoma …
program in Caenorhabditis elegans through the nuclear receptor DAF-12. This mechanism
is conserved in parasitic nematodes to regulate their dauer-like infective larval stage, and as
such, the DAF-12 ligand binding domain has been identified as an important therapeutic
target in human parasitic hookworm species that infect more than 600 million people
worldwide. Here, we report two x-ray crystal structures of the hookworm Ancylostoma …