Severe asthma (SA) is a challenge to control, as patients are not responsive to high doses of systemic corticosteroids (CS). In contrast, mild-moderate asthma (MMA) is responsive to low doses of inhaled CS, indicating that Th2 cells, which are dominant in MMA, do not solely orchestrate SA development. Here, we analyzed broncholalveolar lavage cells isolated from MMA and SA patients and determined that IFN-γ (Th1) immune responses are exacerbated in the airways of individuals with SA, with reduced Th2 and IL-17 responses. We developed a protocol that recapitulates the complex immune response of human SA, including the poor response to CS, in a murine model. Compared with WT animals,
Mahesh Raundhal, Christina Morse, Anupriya Khare, Timothy B. Oriss, Jadranka Milosevic, John Trudeau, Rachael Huff, Joseph Pilewski, Fernando Holguin, Jay Kolls, Sally Wenzel, Prabir Ray, Anuradha Ray
Title and authors | Publication | Year |
---|---|---|
Type 1 immune responses related to viral infection influence corticosteroid response in asthma
John Fahy, Nathan Jackson, Satria Sajuthi, Elmar Pruesse, Camille Moore, Jamie Everman, Cydney Rios, Monica Tang, Marc Gauthier, Sally Wenzel, Eugene Bleecker, Mario Castro, Suzy Comhair, Serpil Erzurum, Annette Hastie, Wendy Moore, Elliot Israel, Bruce Levy, Loren Denlinger, Nizar Jarjour, Mats Johansson, David Mauger, Brenda Phillips, Kaharu Sumino, Prescott Woodruff, Michael Peters, Max Seibold |
American journal of respiratory and critical care medicine | 2024 |
The secretory leukocyte protease inhibitor (SLPI) in pathophysiology of non-communicable diseases: Evidence from experimental studies to clinical applications.
Mongkolpathumrat P, Pikwong F, Phutiyothin C, Srisopar O, Chouyratchakarn W, Unnajak S, Nernpermpisooth N, Kumphune S |
Heliyon | 2024 |
Single-cell analysis reveals alterations in cellular composition and cell-cell communication associated with airway inflammation and remodeling in asthma
Yu X, Li L, Cai B, Zhang W, Liu Q, Li N, Shi X, Yu L, Chen R, Qiu C |
Respiratory Research | 2024 |
Three Main SCFAs Mitigate Lung Inflammation and Tissue Remodeling Nlrp3-Dependent in Murine HDM-Induced Neutrophilic Asthma.
Tagé BSS, Gonzatti MB, Vieira RP, Keller AC, Bortoluci KR, Aimbire F |
Inflammation | 2024 |
New targets for type 2-low asthma
Quoc QL, Choi Y, Hur GY, Park HS |
The Korean Journal of Internal Medicine | 2024 |
Immune Cell-Mediated Autoimmune Responses in Severe Asthma
Cao TB, Quoc QL, Jang JH, Park HS |
Yonsei Medical Journal | 2024 |
IgG from Dermatophagoides pteronyssinus (Der p)-atopic individuals modulates non-atopic thymic B cell phenotype (alfa-4/beta-7) and cytokine production (IFN-γ, IL-9, and IL-10) with direct membrane interaction.
de-Apoena Reche DT, Machado NR, Fagundes BO, Bergamasco IS, de Sousa TR, do Nascimento LA, Cunha FRM, de-Oliveira MG, da-Ressureição Sgnotto F, França CN, Victor JR |
Scientific Reports | 2024 |
Increased expression of CTSC in airway epithelia exacerbates airway remodeling in asthma
Lin Yuan, Ye Yao, Qingwu Qin, Long Chen, Huijun Liu, Xizi Du, Xinyu Wu, Weijie Wang, Qiuyan Qin, Yang Xiang, Ming Ji, Xiangping Qu, Ming Yang, Xiaoqun Qin, Chi Liu |
JCI Insight | 2024 |
Effect of air pollution on asthma.
Zhou X, Sampath V, Nadeau KC |
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology | 2024 |
Genetically predicted asthma and the risk of abnormal spermatozoa
Li Z, Teng Z, Han Z, Zhang Y, Wang Y |
Frontiers in Genetics | 2024 |
Transcriptomic evaluation of skin tape-strips in children with allergic asthma uncovers epidermal barrier dysfunction and asthma-associated biomarkers abnormalities
Del Duca E, Dahabreh D, Kim M, Bar J, Da Rosa JC, Rabinowitz G, Facheris P, Gómez-Arias PJ, Chang A, Utti V, Chowdhury A, Liu Y, Estrada YD, Laculiceanu A, Agache I, Guttman-Yassky E |
Allergy | 2024 |
Asthma Pathogenesis: Phenotypes, Therapies, and Gaps: Summary of the Aspen Lung Conference 2023.
Sharma S, Gerber AN, Kraft M, Wenzel SE |
American journal of respiratory cell and molecular biology | 2024 |
Advances in non-type 2 severe asthma: from molecular insights to novel treatment strategies.
Liu T, Woodruff PG, Zhou X |
European Respiratory Journal | 2024 |
Association between rheumatoid arthritis and chronic respiratory diseases in a Japanese population: A Mendelian randomization study
Shen S, Zeng H, Wei H, Wu L |
Medicine | 2024 |
A Heuristic Approach to Analysis of the Genetic Susceptibility Profile in Patients Affected by Airway Allergies
Lio D, Di Lorenzo G, Brusca I, Scola L, Bellia C, La Piana S, Barrale M, Bova M, Vaccarino L, Forte GI, Pilato G |
Genes | 2024 |
Neutrophil and neutrophil extracellular trap involvement in neutrophilic asthma: A review
Li Y, Yang T, Jiang B |
Medicine | 2024 |
Coinhibitory Molecule VISTA Play an Important Negative Regulatory Role in the Immunopathology of Bronchial Asthma.
Yin J, Chen J, Wang T, Sun H, Yan Y, Zhu C, Huang L, Chen Z |
Journal of asthma and allergy | 2024 |
Calprotectin is regulated by IL-17A and induces steroid hyporesponsiveness in asthma.
Saheb Sharif-Askari N, Mdkhana B, Hafezi S, Khalil BA, Al-Sheakly BK, Halwani H, Saheb Sharif-Askari F, Halwani R |
Inflammation research : official journal of the European Histamine Research Society ... [et al.] | 2024 |
House dust mite-induced asthma exacerbates Alzheimer’s disease changes in the brain of the AppNL-G-F mouse model of disease
Sahu B, Nookala S, Floden AM, Ambhore NS, Sathish V, Klug MG, Combs CK |
Brain, behavior, and immunity | 2024 |
Transcriptomic analysis and validation study of key genes and the HIF‑1α/HO‑1 pathway associated with ferroptosis in neutrophilic asthma
Lin L, Liao Z, Li Y, Pan S, Wu S, Sun QX, Li C |
Experimental and Therapeutic Medicine | 2024 |
Lung antimicrobial proteins and peptides: from host defense to therapeutic strategies
Di YP, Kuhn JM, Mangoni ML |
Physiological Reviews | 2024 |
Immunologic aspects of asthma: from molecular mechanisms to disease pathophysiology and clinical translation
Xie C, Yang J, Gul A, Li Y, Zhang R, Yalikun M, Lv X, Lin Y, Luo Q, Gao H |
Frontiers in Immunology | 2024 |
Kiss1 receptor knockout exacerbates airway hyperresponsiveness and remodeling in a mouse model of allergic asthma.
Ambhore NS, Balraj P, Kumar A, Reza MI, Ramakrishnan YS, Tesch J, Lohana S, Sathish V |
Respiratory research | 2024 |
Serum Vitamin D Level Is Unchanged in Equine Asthma
Mainguy-Seers S, Holcombe SJ, Lavoie JP |
Animals : an Open Access Journal from MDPI | 2024 |
Ion Channels in the Immune Response of Asthma
Yan L, Zhang L, Ogunniyi K, Hong L |
Journal of respiratory biology and translational medicine | 2024 |
4-Octyl-Itaconate Alleviates Airway Eosinophilic Inflammation by Suppressing Chemokines and Eosinophil Development
Yin M, Wadhwa R, Marshall JE, Gillis CM, Kim RY, Dua K, Palsson-McDermott EM, Fallon PG, Hansbro PM, O\u2019Neill LA |
Journal of immunology (Baltimore, Md. : 1950) | 2024 |
Piecing Together the Role of IL-4 Receptor Alpha in Allergic Asthma One Cell at a Time
Curtiss ML, Rothman PB |
American Journal of Respiratory Cell and Molecular Biology | 2024 |
Group 3 Innate Lymphoid Cells: A Potential Therapeutic Target for Steroid Resistant Asthma
Berkinbayeva M, Gu W, Chen Z, Gao P |
Clinical Reviews in Allergy & Immunology | 2024 |
STING‐dependent induction of neutrophilic asthma exacerbation in response to house dust mite
Messaoud\u2010Nacer Y, Culerier E, Rose S, Maillet I, Boussad R, Veront C, Savigny F, Malissen B, Radzikowska U, Sokolowska M, da Silva GV, Edwards MR, Jackson DJ, Johnston SL, Ryffel B, Quesniaux VF, Togbe D |
Allergy | 2024 |