Severe asthma (SA) is a challenge to control, as patients are not responsive to high doses of systemic corticosteroids (CS). In contrast, mild-moderate asthma (MMA) is responsive to low doses of inhaled CS, indicating that Th2 cells, which are dominant in MMA, do not solely orchestrate SA development. Here, we analyzed broncholalveolar lavage cells isolated from MMA and SA patients and determined that IFN-γ (Th1) immune responses are exacerbated in the airways of individuals with SA, with reduced Th2 and IL-17 responses. We developed a protocol that recapitulates the complex immune response of human SA, including the poor response to CS, in a murine model. Compared with WT animals,
Mahesh Raundhal, Christina Morse, Anupriya Khare, Timothy B. Oriss, Jadranka Milosevic, John Trudeau, Rachael Huff, Joseph Pilewski, Fernando Holguin, Jay Kolls, Sally Wenzel, Prabir Ray, Anuradha Ray
Title and authors | Publication | Year |
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Mast cells as sources of cytokines, chemokines, and growth factors
K Mukai, M Tsai, H Saito, SJ Galli |
Immunological Reviews | 2018 |
T H 1 signatures are present in the lower airways of children with severe asthma, regardless of allergic status
JA Wisniewski, LM Muehling, JD Eccles, BJ Capaldo, R Agrawal, DA Shirley, JT Patrie, LJ Workman, AJ Schuyler, MG Lawrence, WG Teague, JA Woodfolk |
Journal of Allergy and Clinical Immunology | 2018 |
Updates on T helper type 17 immunity in respiratory disease
N Iwanaga, JK Kolls |
Immunology | 2018 |
T cells in severe childhood asthma
AG Paul, LM Muehling, JD Eccles, JA Woodfolk |
Cell | 2018 |
IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma
NR Bhakta, SA Christenson, S Nerella, OD Solberg, CP Nguyen, DF Choy, KL Jung, S Garudadri, LR Bonser, JL Pollack, LT Zlock, DJ Erle, C Langelier, JL Derisi, JR Arron, JV Fahy, PG Woodruff |
American journal of respiratory and critical care medicine | 2018 |
Puerarin alleviates delayed-type hypersensitivity via cytokine inhibition by modulating Th1/Th2 balance
J Tong, XJ Hu, WQ Cai, X Dai, L Wang |
Experimental and therapeutic medicine | 2018 |
Hormones, sex, and asthma
JA Yung, H Fuseini, DC Newcomb |
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology | 2018 |
Rhinovirus infection induces distinct transcriptome profiles in polarized human macrophages
C Rajput, MP Walsh, BN Eder, EE Metitiri, AP Popova, MB Hershenson |
Physiological genomics | 2018 |
IFN-stimulated Genes and Non–Type 2 Inflammation. New Pathway or Red Herring?
S Sharma, F Holguin |
American journal of respiratory and critical care medicine | 2018 |
Understanding Asthma Phenotypes, Endotypes, and Mechanisms of Disease
ME Kuruvilla, FE Lee, GB Lee |
Clinical Reviews in Allergy & Immunology | 2018 |
Influence of viral infection on the relationships between airway cytokines and lung function in asthmatic children
TC Lewis, EE Metitiri, GB Mentz, X Ren, AR Carpenter, AM Goldsmith, KE Wicklund, BN Eder, AT Comstock, JM Ricci, SR Brennan, GL Washington, KB Owens, B Mukherjee, TG Robins, SA Batterman, MB Hershenson |
Respiratory Research | 2018 |
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis
CC Campa, RL Silva, JP Margaria, T Pirali, MS Mattos, LR Kraemer, DC Reis, G Grosa, F Copperi, EM Dalmarco, RC Lima-Júnior, S Aprile, V Sala, FD Bello, DS Prado, JC Alves-Filho, C Medana, GD Cassali, GC Tron, MM Teixeira, E Ciraolo, RC Russo, E Hirsch |
Nature Communications | 2018 |