Severe asthma (SA) is a challenge to control, as patients are not responsive to high doses of systemic corticosteroids (CS). In contrast, mild-moderate asthma (MMA) is responsive to low doses of inhaled CS, indicating that Th2 cells, which are dominant in MMA, do not solely orchestrate SA development. Here, we analyzed broncholalveolar lavage cells isolated from MMA and SA patients and determined that IFN-γ (Th1) immune responses are exacerbated in the airways of individuals with SA, with reduced Th2 and IL-17 responses. We developed a protocol that recapitulates the complex immune response of human SA, including the poor response to CS, in a murine model. Compared with WT animals,
Mahesh Raundhal, Christina Morse, Anupriya Khare, Timothy B. Oriss, Jadranka Milosevic, John Trudeau, Rachael Huff, Joseph Pilewski, Fernando Holguin, Jay Kolls, Sally Wenzel, Prabir Ray, Anuradha Ray
Title and authors | Publication | Year |
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Machine Learning Implicates the IL-18 Signaling Axis In Severe Asthma
Matthew Camiolo, Xiuxia Zhou, Qi Wei, Humberto E Trejo Bittar, Naftali Kaminski, Anuradha Ray, Sally Wenzel. |
JCI Insight | 2021 |
T-Helper Cells: Methods and Protocols
F Annunziato, L Maggi, A Mazzoni |
2021 | |
Lung Inflammation in Health and Disease, Volume I
YX Wang |
2021 | |
Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD
BW Lewis, ML Ford, LK Rogers, RD Britt |
Antioxidants | 2021 |
The Role of CD4+ T Cells and Microbiota in the Pathogenesis of Asthma
J Jeong, HK Lee |
International journal of molecular sciences | 2021 |
Ruxolitinib Ameliorates Airway Hyperresponsiveness and Lung Inflammation in a Corticosteroid-Resistant Murine Model of Severe Asthma
H Subramanian, T Hashem, D Bahal, AK Kammala, K Thaxton, R Das |
Frontiers in immunology | 2021 |
Na + /H + Exchanger Regulatory Factor 1 Mediates the Pathogenesis of Airway Inflammation in a Murine Model of House Dust Mite–Induced Asthma
AK Kammala, D Bahal, C Yang, RA Panettieri, R Das, H Subramanian |
Journal of immunology (Baltimore, Md. : 1950) | 2021 |
Asthma and Obesity: Two Diseases on the Rise and Bridged by Inflammation
M Bantulà, J Roca-Ferrer, E Arismendi, C Picado |
Journal of Clinical Medicine | 2021 |
Prevalence of Anemia in Pediatric Patients According to Asthma Control: Propensity Score Analysis
JE Chang, HM Lee, J Kim, K Rhew |
Journal of asthma and allergy | 2021 |
Epithelial Barrier Dysfunction in Chronic Respiratory Diseases
FM Carlier, C de Fays, C Pilette |
Frontiers in physiology | 2021 |
Combination blockade of OX40L and CD30L inhibits allergen-driven memory TH2 cell reactivity and lung inflammation
DT Gracias, GS Sethi, AK Mehta, H Miki, RK Gupta, H Yagita, M Croft |
Journal of Allergy and Clinical Immunology | 2021 |
Our evolving view of neutrophils in defining the pathology of chronic lung disease
KT Mincham, N Bruno, A Singanayagam, RJ Snelgrove |
Immunology | 2021 |
The Effect of Unconventional Cytokine Combinations on NK-Cell Responses to Viral Infection
DE Ochayon, SN Waggoner |
Frontiers in immunology | 2021 |
Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise
E Verdú, J Homs, P Boadas-Vaello |
International journal of environmental research and public health | 2021 |
Dual role for CXCR3 and CCR5 in asthmatic type 1 inflammation
M Gauthier, SL Kale, TB Oriss, K Scholl, S Das, H Yuan, S Hu, J Chen, M Camiolo, P Ray, S Wenzel, A Ray |
Journal of Allergy and Clinical Immunology | 2021 |
Cyclic-di-GMP Induces STING-Dependent ILC2 to ILC1 Shift During Innate Type 2 Lung Inflammation
KJ Cavagnero, JH Badrani, LH Naji, MB Amadeo, AS Leng, LD Lacasa, AN Strohm, SR Renusch, SS Gasparian, TA Doherty |
Frontiers in immunology | 2021 |
The chemokine CX3CL1/fractalkine regulates immunopathogenesis during fungal-associated allergic airway inflammation
MS Godwin, MJ Jones, JP Blackburn, Z Yu, S Matalon, AT Hastie, DA Meyers, C Steele |
American journal of physiology. Lung cellular and molecular physiology | 2021 |
Immune responses and exacerbations in severe asthma
MJ Camiolo, SL Kale, TB Oriss, M Gauthier, A Ray |
Current Opinion in Immunology | 2021 |
High-dimensional profiling clusters asthma severity by lymphoid and non-lymphoid status
MJ Camiolo, X Zhou, TB Oriss, Q Yan, M Gorry, W Horne, JB Trudeau, K Scholl, W Chen, JK Kolls, P Ray, FJ Weisel, NM Weisel, N Aghaeepour, K Nadeau, SE Wenzel, A Ray |
Cell Reports | 2021 |
Irg1/itaconate metabolic pathway is a crucial determinant of dendritic cells immune-priming function and contributes to resolute allergen-induced airway inflammation
AK Jaiswal, J Yadav, S Makhija, S Mazumder, AK Mitra, A Suryawanshi, M Sandey, A Mishra |
Mucosal Immunology | 2021 |
Respiratory Viral and Bacterial Factors That Influence Early Childhood Asthma
N Mthembu, P Ikwegbue, F Brombacher, S Hadebe |
2021 | |
Severe Adult Asthmas: Integrating Clinical Features, Biology, and Therapeutics to Improve Outcomes
SE Wenzel |
American journal of respiratory and critical care medicine | 2021 |
Androgen receptor activation alleviates airway hyperresponsiveness, inflammation, and remodeling in a murine model of asthma
RS Kalidhindi, NS Ambhore, P Balraj, T Schmidt, MN Khan, V Sathish |
American journal of physiology. Lung cellular and molecular physiology | 2021 |
Lung CD103 + dendritic cells and Clec9a signaling are required for neonatal hyperoxia-induced inflammatory responses to rhinovirus infection
TX Cui, CT Fulton, AE Brady, YJ Zhang, AM Goldsmith, AP Popova |
American journal of physiology. Lung cellular and molecular physiology | 2021 |
Biomolecular endotype factors involved in COVID-19 airway infectivity: A systematic review
N Jain, R Varman, JA Tarbox, T Nguyen |
Auris, Nasus, Larynx | 2021 |
Nonrespiratory Comorbidities in Asthma
JC Cardet, AA Bulkhi, RF Lockey |
The Journal of Allergy and Clinical Immunology: In Practice | 2021 |
Characterization of T2-Low and T2-High Asthma Phenotypes in Real-Life
FL Ricciardolo, AE Sprio, A Baroso, F Gallo, E Riccardi, F Bertolini, V Carriero, E Arrigo, G Ciprandi |
Biomedicines | 2021 |
Effect of Src tyrosine kinase on a rat model of asthma
M Wu, J Yang, T Liu, P Xuan, B Bu, X Xu, R Wu |
Experimental and therapeutic medicine | 2021 |
The expression and function of programmed death-ligand 1 and related cytokines in neutrophilic asthma
Y Ren, H Dong, J Liao, H Sun, T Wang, W Gu, X Zhang, Y Yan, W Ji, Z Chen, C Zhu |
Annals of translational medicine | 2021 |
Corticosteroid Insensitivity Persists in the Absence of STAT1 Signaling in Severe Allergic Airway Inflammation
B Lewis, D Jackson, S Amici, J Walum, M Guessas, S Guessas, E Coneglio, A Boda, M Guerau-de-Arellano, M Grayson, R Britt |
American journal of physiology. Lung cellular and molecular physiology | 2021 |
Neuropilin‐2 regulates airway inflammation in a neutrophilic asthma model
R Immormino, C Jania, S Tilley, T Moran |
Immunity, Inflammation and Disease | 2021 |
Immunobiology of Steroid-Unresponsive Severe Asthma
C Marshall, K Hasani, N Mookherjee |
2021 | |
JAK inhibitors for asthma
Georas SN, Donohue P, Connolly M, Wechsler ME |
Journal of Allergy and Clinical Immunology | 2021 |
Endotypes of chronic rhinosinusitis: Relationships to disease phenotypes, pathogenesis, clinical findings, and treatment approaches
Kato A, Peters AT, Stevens WW, Schleimer RP, Tan BK, Kern RC |
Allergy | 2021 |