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Douglas Marvel, Dmitry I. Gabrilovich
Published July 13, 2015
Citation Information: J Clin Invest. 2015;125(9):3356-3364. https://doi.org/10.1172/JCI80005.
Citation Information: J Clin Invest. 2015;125(9):3356-3364. https://doi.org/10.1172/JCI80005.
Abstract
Our understanding of the role of myeloid-derived suppressor cells (MDSCs) in cancer is becoming increasingly complex. In addition to their eponymous role in suppressing immune responses, they directly support tumor growth, differentiation, and metastasis in a number of ways that are only now beginning to be appreciated. It is because of this increasingly complex role that these cells may become an important factor in the treatment of human cancer. In this Review, we discuss the most pertinent and controversial issues of MDSC biology and their role in promoting cancer progression and highlight how these cells may be used in the clinic, both as prognostic factors and as therapeutic targets.
Authors
Douglas Marvel, Dmitry I. Gabrilovich
Total citations by year
Citation information
Citations to this article in year 2019 (62)
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Broadening the Impact of Immunotherapy to Pancreatic Cancer: Challenges and Opportunities
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D Adah, Y Yang, Q Liu, K Gadidasu, Z Tao, S Yu, L Dai, X Li, S Zhao, L Qin, L Qin, X Chen |
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Cysteine Cathepsins in Tumor-Associated Immune Cells
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Trabectedin Reduces Skeletal Prostate Cancer Tumor Size in Association with Effects on M2 Macrophages and Efferocytosis
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Different role of circulating myeloid-derived suppressor cells in patients with multiple myeloma undergoing autologous stem cell transplantation
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|
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|
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|
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|
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|
The prognostic value of myeloid derived suppressor cell level in hepatocellular carcinoma: A systematic review and meta-analysis
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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