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Andrew J. Holland, Don W. Cleveland
Published November 26, 2012
Citation Information: J Clin Invest. 2012;122(12):4325-4328. https://doi.org/10.1172/JCI66420.
Citation Information: J Clin Invest. 2012;122(12):4325-4328. https://doi.org/10.1172/JCI66420.
Abstract
The mitotic checkpoint plays an important role in preventing chromosome segregation errors and the production of aneuploid progeny. In this issue, Zhang et al. examine mice and cells lacking the deubiquitinating enzyme USP44. Surprisingly, they find that USP44 prevents chromosome segregation errors through a function independent of its previously identified role in the mitotic checkpoint. Usp44-null animals develop aneuploidy and experience increased rates of tumorigenesis, implicating USP44 as novel tumor suppressor.
Authors
Andrew J. Holland, Don W. Cleveland
Total citations by year
Citation information
Citations to this article in year 2023 (2)
| Title and authors | Publication | Year |
|---|---|---|
|
USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy
Campos-Iglesias D, Fraile JM, Bretones G, Montero AA, Bonzon-Kulichenko E, Vázquez J, López-Otín C, Freije JM |
Cell Death and Disease | 2023 |
|
Integrated network findings reveal ubiquitin-specific protease 44 overexpression suppresses tumorigenicity of liver cancer
Zhou H, Yang L, Lin X, Chan TF, Lee NP, Tse WK, Zhang X, Li R, Lai KP |
Aging | 2023 |
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