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Andrew J. Holland, Don W. Cleveland
Published November 26, 2012
Citation Information: J Clin Invest. 2012;122(12):4325-4328. https://doi.org/10.1172/JCI66420.
Citation Information: J Clin Invest. 2012;122(12):4325-4328. https://doi.org/10.1172/JCI66420.
Abstract
The mitotic checkpoint plays an important role in preventing chromosome segregation errors and the production of aneuploid progeny. In this issue, Zhang et al. examine mice and cells lacking the deubiquitinating enzyme USP44. Surprisingly, they find that USP44 prevents chromosome segregation errors through a function independent of its previously identified role in the mitotic checkpoint. Usp44-null animals develop aneuploidy and experience increased rates of tumorigenesis, implicating USP44 as novel tumor suppressor.
Authors
Andrew J. Holland, Don W. Cleveland
Total citations by year
Citation information
Citations to this article in year 2015 (4)
| Title and authors | Publication | Year |
|---|---|---|
|
Centrosomes and cancer: revisiting a long-standing relationship
P Gönczy |
Nature Reviews Cancer | 2015 |
|
Role of Deubiquitinating Enzymes in DNA Repair
Y Kee, TT Huang |
Molecular and cellular biology | 2015 |
|
CENP-A nucleosomes localize to transcription factor hotspots and subtelomeric sites in human cancer cells
RK Athwal, MP Walkiewicz, S Baek, S Fu, M Bui, J Camps, T Ried, MH Sung, Y Dalal |
Epigenetics & chromatin | 2015 |
|
The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells
K Yan, L Li, X Wang, R Hong, Y Zhang, H Yang, M Lin, S Zhang, Q He, D Zheng, J Tang, Y Yin, G Shao |
The Journal of Cell Biology | 2015 |
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