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Andrew J. Holland, Don W. Cleveland
Published November 26, 2012
Citation Information: J Clin Invest. 2012;122(12):4325-4328. https://doi.org/10.1172/JCI66420.
Citation Information: J Clin Invest. 2012;122(12):4325-4328. https://doi.org/10.1172/JCI66420.
Abstract
The mitotic checkpoint plays an important role in preventing chromosome segregation errors and the production of aneuploid progeny. In this issue, Zhang et al. examine mice and cells lacking the deubiquitinating enzyme USP44. Surprisingly, they find that USP44 prevents chromosome segregation errors through a function independent of its previously identified role in the mitotic checkpoint. Usp44-null animals develop aneuploidy and experience increased rates of tumorigenesis, implicating USP44 as novel tumor suppressor.
Authors
Andrew J. Holland, Don W. Cleveland
Total citations by year
Citation information
Citations to this article in year 2019 (3)
| Title and authors | Publication | Year |
|---|---|---|
|
Ubiquitin‐specific protease 44 inhibits cell growth by suppressing AKT signaling in non‐small cell lung cancer
YK Zhang, WZ Tian, RS Zhang, YJ Zhang, HT Ma |
The Kaohsiung Journal of Medical Sciences | 2019 |
|
USP44 Promotes the Tumorigenesis of Prostate Cancer Cells through EZH2 Protein Stabilization
Jae Min Park, Jae Eun Lee, Chan Mi Park, Jung Hwa Kim |
Molecules and Cells | 2019 |
|
The role of ubiquitin-specific peptidases in cancer progression
MJ Young, KC Hsu, TE Lin, WC Chang, JJ Hung |
Journal of Biomedical Science | 2019 |
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